Hotels in Santee

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Check prices for these dates

Tonight
Apr 17 - Apr 18
Tomorrow
Apr 18 - Apr 19
This weekend
Apr 17 - Apr 19
Next weekend
Apr 24 - Apr 26

Where to stay in Santee?

Free breakfast
Hampton Inn Santee-I-95
Hampton Inn Santee-I-95
2.5 star property
Santee
9.6 out of 10, Exceptional, (1,002 reviews)
The price is $124
$138 total
includes taxes & fees
May 10 - May 11
Hampton Inn Santee-I-95
Property amenity
Fairfield Inn & Suites by Marriott Santee
Fairfield Inn & Suites by Marriott Santee
3.0 star property
Santee
9.8 out of 10, Exceptional, (1,002 reviews)
Guests love this quiet Santee hotel for its helpful staff and complimentary breakfast. The outdoor pool and health club offer refreshing workout options, while free parking and WiFi add convenience. Golf enthusiasts will appreciate the nearby Santee Cooper Country Club.
The price is $134
$149 total
includes taxes & fees
Apr 23 - Apr 24
Fairfield Inn & Suites by Marriott Santee
Free daily buffet breakfast
Tru By Hilton Santee
Tru By Hilton Santee
2.5 star property
Santee
9.2 out of 10, Wonderful, (792 reviews)
Bright, modern hotel near Santee National Golf Club with a refreshing indoor pool for year-round swimming. Guests love the complimentary breakfast, 24-hour fitness center, and helpful staff. Free WiFi and parking add convenience to your Santee visit.
The price is $113
$125 total
includes taxes & fees
May 4 - May 5
Tru By Hilton Santee
Exterior
Best Western Plus Santee Inn
Best Western Plus Santee Inn
2.5 star property
Santee
8.8 out of 10, Excellent, (1,001 reviews)
The price is $119
$132 total
includes taxes & fees
Apr 29 - Apr 30
Best Western Plus Santee Inn
Frette Italian sheets, premium bedding, pillowtop beds, blackout drapes
Comfort Inn & Suites Santee
Comfort Inn & Suites Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1,002 reviews)
This peaceful hotel in Santee's entertainment district offers a quiet retreat with free breakfast and parking. Located near Santee Cooper Country Club, guests can enjoy the fitness center or take a refreshing dip in the seasonal pool. The staff earns consistent praise for their helpfulness.
The price is $110
$122 total
includes taxes & fees
May 10 - May 11
Comfort Inn & Suites Santee
Exterior
Holiday Inn Santee by IHG
Holiday Inn Santee by IHG
3.0 star property
Santee
8.2 out of 10, Very Good, (1,000 reviews)
Swing into action at this golf-adjacent hotel featuring an indoor pool and 24-hour fitness center. Relax on the terrace or enjoy a drink at the bar after playing nearby Santee Cooper Country Club. Clean rooms with refrigerators and microwaves create a comfortable home base.
The price is $130
$144 total
includes taxes & fees
May 4 - May 5
Holiday Inn Santee by IHG
Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board, free WiFi
Baymont by Wyndham Santee
Baymont by Wyndham Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1,438 reviews)
Escape to this quiet Santee hotel where comfortable beds await after exploring local golf clubs. Free perks include daily continental breakfast, WiFi, and parking. Guests praise the convenient location close to everything they need.
The price is $80
$89 total
includes taxes & fees
Apr 19 - Apr 20
Baymont by Wyndham Santee
Free daily full breakfast
Quality Inn & Suites Santee I-95
Quality Inn & Suites Santee I-95
2.5 star property
Santee
6.0 out of 10, (508 reviews)
Wake up to free breakfast at this convenient Santee hotel with 7 dining options and a seasonal outdoor pool. After exploring nearby Santee Cooper Country Club, unwind at the bar. Clean rooms, helpful staff, and free WiFi and parking enhance your stay.
The price is $54
$66 total
includes taxes & fees
Apr 23 - Apr 24
Quality Inn & Suites Santee I-95
In-room safe, iron/ironing board, free WiFi, bed sheets
Travelodge by Wyndham Santee
Travelodge by Wyndham Santee
2.0 star property
Santee
7.2 out of 10, Good, (717 reviews)
The price is $63
$70 total
includes taxes & fees
Apr 26 - Apr 27
Travelodge by Wyndham Santee
Lobby
Super 8 by Wyndham Santee
Super 8 by Wyndham Santee
2.0 star property
Santee
6.8 out of 10, (450 reviews)
Overlooking a golf course, this tranquil motel offers a refreshing seasonal outdoor pool and complimentary breakfast served daily. Located near Santee Cooper Country Club, guests enjoy free WiFi and parking during their stay.
The price is $75
$83 total
includes taxes & fees
Apr 19 - Apr 20
Super 8 by Wyndham Santee
Lobby
Ramada by Wyndham Santee I-95
Ramada by Wyndham Santee I-95
2.0 star property
Santee
6.4 out of 10, (554 reviews)
Steps from Santee Cooper Country Club, this hotel offers rooms with refrigerators and microwaves. After a round of golf, enjoy the poolside bar and on-site restaurant. Free WiFi and parking make exploring nearby attractions easy.
The price is $78
$87 total
includes taxes & fees
Apr 19 - Apr 20
Ramada by Wyndham Santee I-95
Exterior
Red Roof Inn Santee
Red Roof Inn Santee
2.0 star property
Santee
6.6 out of 10, (650 reviews)
Minutes from Santee Cooper Country Club, this welcoming hotel offers free WiFi, parking, and daily continental breakfast. Adventure seekers will appreciate the nearby water skiing opportunities, while golf enthusiasts can enjoy Santee National Golf Club just a short drive away.
The price is $61
$68 total
includes taxes & fees
Apr 20 - Apr 21
Red Roof Inn Santee
Desk, iron/ironing board, free WiFi, bed sheets
Econo Lodge Santee
Econo Lodge Santee
2.0 star property
Santee
6.4 out of 10, (312 reviews)
Located near Santee Cooper Country Club, this hotel offers free WiFi and parking. You'll appreciate the 24-hour front desk service while exploring nearby attractions including Santee National Golf Club.
The price is $68
$76 total
includes taxes & fees
May 3 - May 4
Econo Lodge Santee
Desk, laptop workspace, iron/ironing board, free WiFi
SureStay Hotel by Best Western Manning
SureStay Hotel by Best Western Manning
2.5 star property
Manning
8.6 out of 10, Excellent, (1,000 reviews)
Travelers appreciate the helpful staff at this hotel in Manning. Start your day with complimentary full breakfast before exploring. Enjoy conveniences like free WiFi and parking, plus business-friendly amenities for a relaxing stay.
The price is $104
$115 total
includes taxes & fees
Apr 19 - Apr 20
SureStay Hotel by Best Western Manning
Interior entrance
Hampton Inn Manning
Hampton Inn Manning
2.5 star property
Manning
8.4 out of 10, Very Good, (1,000 reviews)
Unwind at this Manning hotel where helpful staff receive consistent praise from travelers. Work out anytime in the 24-hour fitness center or grab a drink at the bar. Free perks include breakfast, WiFi and parking in this clean, convenient spot.
The price is $119
$132 total
includes taxes & fees
May 10 - May 11
Hampton Inn Manning
Standard Room Double Bed | Desk, free WiFi, bed sheets
Best Inn of Manning
Best Inn of Manning
2.5 star property
Manning
6.8 out of 10, (25 reviews)
The price is $68
$76 total
includes taxes & fees
Apr 26 - Apr 27
Best Inn of Manning
Deluxe Room, 1 King Bed, Non Smoking | Iron/ironing board, free WiFi, bed sheets
Baymont by Wyndham Manning
Baymont by Wyndham Manning
2.5 star property
Manning
6.8 out of 10, (1,001 reviews)
Unwind in comfort at this Manning hotel, offering a complimentary continental breakfast to start your day. Clean rooms provide a peaceful retreat, while free WiFi keeps you connected. The helpful staff ensures a pleasant stay, with convenient free parking included.
The price is $83
$92 total
includes taxes & fees
Apr 26 - Apr 27
Baymont by Wyndham Manning
Lobby
Quality Inn Manning I-95
Quality Inn Manning I-95
2.5 star property
Manning
6.8 out of 10, (514 reviews)
Enjoy a quiet stay at this serene Manning retreat with complimentary buffet breakfast and WiFi. Just off I-95 with free parking, this hotel offers easy access to area attractions while providing a peaceful environment for a restful night's sleep.
The price is $86
$96 total
includes taxes & fees
Apr 26 - Apr 27
Quality Inn Manning I-95
Reception
Super 8 by Wyndham Manning
Super 8 by Wyndham Manning
2.0 star property
Manning
6.4 out of 10, (402 reviews)
Wake up to complimentary on-the-go breakfast at this Manning motel where travelers praise the helpful staff. Enjoy free WiFi and parking during your stay, with Florence Regional Airport just 50 minutes away by car.
The price is $61
$68 total
includes taxes & fees
Apr 26 - Apr 27
Super 8 by Wyndham Manning
1 bedroom
Starlight Stays
Starlight Stays
2.5 star property
Manning
8.0 out of 10, Very Good, (12 reviews)
This comfortable hotel offers peaceful accommodation with in-room coffeemakers and daily housekeeping services. Just a short drive from Florence Regional Airport and popular Wyboo Golf Club, Starlight Stays provides a convenient base for exploring Manning.
The price is $66
$73 total
includes taxes & fees
Apr 18 - Apr 19
Starlight Stays
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Get last-minute hotel deals in Santee and save more

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Showing deals for:Apr 17 - Apr 18
Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board, free WiFi
Baymont by Wyndham Santee

Baymont by Wyndham Santee

Baymont by Wyndham Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1,438 reviews)
The price is $140
per night
$155 total
includes taxes & fees
Baymont by Wyndham Santee
Showing deals for:Apr 18 - Apr 19
Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board, free WiFi
Baymont by Wyndham Santee

Baymont by Wyndham Santee

Baymont by Wyndham Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1,438 reviews)
The price is $120
per night
$133 total
includes taxes & fees
Baymont by Wyndham Santee
Showing deals for:Apr 24 - Apr 26
Free daily buffet breakfast
Tru By Hilton Santee

Tru By Hilton Santee

Tru By Hilton Santee
2.5 star property
Santee
9.2 out of 10, Wonderful, (792 reviews)
The price is $154
per night
$341 total
includes taxes & fees
Tru By Hilton Santee

Check out family-friendly hotels in Santee

Property amenity
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
3.0 star property
Santee
9.8 out of 10, Exceptional, (1002)
The price is $134
$149 total
includes taxes & fees
Apr 23 - Apr 24
Fairfield Inn & Suites by Marriott Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

When is the best time to visit Santee?

Our prices for hotels in Santee are cheapest in January
Price trends for hotels in Santee
Pricing is based on two traveler single night rates
View properties in April
Currently viewing crowd sizes and weather for April.
Typical weather for Santee
April
High 24°C / low 13°C. Sunny most days.
View properties in April
24°
weather_sun
April, no crowd data, average high temperature 24 degrees Celsius, average low temperature 13 degrees Celsius. Sunny most days.
13°
28°
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May, no crowd data, average high temperature 28 degrees Celsius, average low temperature 17 degrees Celsius. Sunny most days.
17°
31°
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June, no crowd data, average high temperature 31 degrees Celsius, average low temperature 21 degrees Celsius. Sunny most days.
21°
33°
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July, no crowd data, average high temperature 33 degrees Celsius, average low temperature 23 degrees Celsius. Sunny most days.
23°
32°
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August, no crowd data, average high temperature 32 degrees Celsius, average low temperature 23 degrees Celsius. Sunny most days.
23°
29°
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September, no crowd data, average high temperature 29 degrees Celsius, average low temperature 20 degrees Celsius. Sunny most days.
20°
24°
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October, no crowd data, average high temperature 24 degrees Celsius, average low temperature 15 degrees Celsius. Sunny most days.
15°
19°
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November, no crowd data, average high temperature 19 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
9°
15°
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December, no crowd data, average high temperature 15 degrees Celsius, average low temperature 7 degrees Celsius. Sunny most days.
7°
13°
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January, no crowd data, average high temperature 13 degrees Celsius, average low temperature 4 degrees Celsius. Sunny most days.
4°
16°
weather_sun
February, no crowd data, average high temperature 16 degrees Celsius, average low temperature 6 degrees Celsius. Sunny most days.
6°
19°
weather_sun
March, no crowd data, average high temperature 19 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
9°
Monthly weather averages (˚C)

Top landmarks in Santee

Santee State Park

4.0/5 (219 reviews)
Rent a pier cabin at Santee State Park for unmatched views of South Carolina's largest lake. Explore 10 miles of trails winding through cypress swamps where alligators and diverse bird species await.
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Santee Cooper Country Club

3.9/5 (94 reviews)
Wind through majestic pines on George Cobb's scenic 18-hole course overlooking Lake Marion. The signature closing hole offers a panoramic view that makes the challenging doglegs and strategic bunkering worth every swing.
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Learn more about Santee

Tee off at championship golf courses or cast a line in Lake Marion's fish-rich waters where locals claim the bass practically jump into your boat. The Santee National Wildlife Refuge offers hiking trails where alligators sun themselves with reptilian nonchalance. Interstate 95 crosses the lake on a causeway that provides views worth pulling over for (safely, of course). Santee State Park delivers lakeside tranquility that makes visitors forget their phones exist. This resort town punches well above its weight with dining options that range from fresh-caught catfish to surprisingly sophisticated fare. The recent addition of the Santee Cooper Regional Water System has locals buzzing about growth while still cherishing their small-town atmosphere.

See all hotels in Santee
Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina

Check out reviews of Santee hotels guests love

Baymont by Wyndham Santee

Baymont by Wyndham Santee

8/10 Good
"Excellent value. "
adam 1-night trip
Posted 6 hours ago
Baymont by Wyndham Santee

Frequently asked questions

What accommodations do travelers like in Santee?
Guests like Baymont by Wyndham Santee, Tru By Hilton Santee and Best Western Plus Santee Inn.
Can I book refundable accommodations in Santee?
If you want the flexibility to change your plans to Santee, most accommodations provide refundable* rates you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.
Where should I stay in Santee if I'm looking for a reasonably priced accommodation?
A few inexpensive options worth considering are Baymont by Wyndham Santee, Tru By Hilton Santee and Best Western Plus Santee Inn.
Where can I stay in Santee if I want a vacation rental instead of a hotel?
Browse 8 vacation homes on our site. You also might want to book one of 99 condos for your trip.
What will the weather in Santee be like during my vacation?
July and August are typically the warmest months in Santee when the average temp is 79°F. January and February are the coldest months when the average temperature is 52°F. August and July are the months with the most rain.
Why should I book my Santee hotel with Hotels.com?
There are lots of reasons to book your Santee trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.