A swamp with tall trees and water reflecting the greenery.

Hotels in Saint Matthews

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Where to stay in Saint Matthews?

A spacious dining area with multiple tables and chairs, a reception desk, and large windows providing natural light.

An outdoor patio area with a fire pit, seating, and tables.

A hotel room with two beds, a seating area, and a large abstract painting on the wall.

A modern lobby with a wooden ceiling, a central seating area with a round table, and a bar with a variety of bottles.

1. SpringHill Suites by Marriott Orangeburg

Orangeburg

$109

$121 total

includes taxes & fees

Oct 20 - Oct 21

A self-service kiosk with a beverage cooler, microwave, and various food items.

A breakfast counter with a sign reading 'TOP IT BREAKFAST,' a coffee machine, a yogurt dispenser, and various food items.

A modern hotel lobby with a reception desk, blue and gray seating, a TV screen, and unique pendant lighting.

A modern interior with a dining area, seating arrangements, and a reception desk.

2. Tru by Hilton Orangeburg

Orangeburg

$110

$122 total

includes taxes & fees

Nov 1 - Nov 2

A modern indoor pool area with a table and chairs, large windows, and a poolside lounge with sun loungers.

A lobby with a reception desk, a staircase, and seating area with orange chairs.

A modern indoor swimming pool with clear glass walls, sunlit lounge areas, and a view of greenery outside.

A modern kitchen with a wooden table and bench, blue cabinets, and a yellow pendant light fixture.

3. Spark by Hilton Orangeburg

Orangeburg

$98

$108 total

includes taxes & fees

Oct 18 - Oct 19

A breakfast bar with pastries, fruits, and a vase with flowers.

A hotel room with two beds, a nightstand, and two wall-mounted lamps.

A hotel bathroom with a sink, mirror, towel rack, and a door leading to the bedroom.

A Travelodge motel with a parking lot and a signboard.

4. Travelodge by Wyndham Orangeburg

Orangeburg

$62

$69 total

includes taxes & fees

Oct 15 - Oct 16

A lobby with a reception desk, a sofa, a coffee station, and a flag.

A modern restaurant with a counter, seating area, and a food display.

A modern hotel lobby with a green ceiling, a grey sofa, a patterned ottoman, a wooden bench, and a chair with a geometric throw.

A Holiday Inn Express & Suites building with a clear entrance, a covered waiting area, and a landscaped garden.

5. Holiday Inn Express & Suites Orangeburg by IHG

Orangeburg

$118

$131 total

includes taxes & fees

Nov 8 - Nov 9

A stone fireplace with a television mounted above it, a small statue on the mantel, and a wooden cabinet to the left.

A workspace with two desks, each with a computer monitor, keyboard, and chair.

A reception area with a wooden reception desk, a welcome mat, a vending machine, and a clock on the wall.

A corner market with a refrigerator stocked with beverages and snacks.

6. Fairfield Inn by Marriott Orangeburg

Orangeburg

$101

$112 total

includes taxes & fees

Nov 1 - Nov 2

A spacious lobby with a sofa, chairs, a coffee table, and a staircase with a green leaf-patterned wall.

A dining area with wooden tables and chairs, a large window with a view, a flat-screen TV, and a vending machine.

A swimming pool with lounge chairs and umbrellas, surrounded by a building with a modern design.

A reception area with a staircase, reception desk, and seating area with blue sofas.

7. Sleep Inn Orangeburg

Orangeburg

$88

$98 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with a bed, a desk, a chair, a TV, and a window with curtains.

A spacious living area with a ceiling fan, a sofa, a coffee table, and a TV.

A spacious lobby with a central round table and chairs, a bar area, and a staircase leading to an upper level.

A spacious dining area with a kitchen in the background, featuring a modern design with a ceiling fan, a clock, and a flat-screen TV mounted on the wall.

8. Quality Inn & Suites Orangeburg

Orangeburg

$50

$56 total

includes taxes & fees

Oct 18 - Oct 19

A modern kitchen with a long counter, equipped with coffee makers, a kettle, and a microwave.

A living room with a brown leather sofa, a matching armchair, a coffee table, and a striped rug.

A multi-story hotel with a covered entrance, balconies, and a parking area.

A hotel room with a beige armchair, a black ottoman, a standing lamp, and an air conditioning unit.

9. Super 8 by Wyndham, Orangeburg

Orangeburg

$59

$65 total

includes taxes & fees

Oct 15 - Oct 16

A Hampton Inn & Suites hotel with a modern design, featuring a parking lot and a well-lit entrance.

A hotel room with a large bed, a desk with a flat-screen TV, a chair, a desk lamp, and a window with curtains.

A modern dining area with tables and chairs, large windows with sheer curtains, and pendant lighting.

A snack shop with a sign reading "Hampton Suite Shop" and a variety of snacks and drinks on display.

10. Hampton Inn & Suites Orangeburg

Orangeburg

$136

$150 total

includes taxes & fees

Nov 1 - Nov 2

A reception desk with a flat-screen TV, a Dell computer, and a door.

A hotel reception area with a counter, coffee machines, and a refrigerator.

A Red Roof Inn with two red leather armchairs and a small wooden table in front of a stone-patterned wall.

A two-story building with a grey facade, large windows, and a covered entrance area.

11. Red Roof Inn Orangeburg

Orangeburg

$61

$68 total

includes taxes & fees

Oct 20 - Oct 21

A hotel room with two beds, a desk, and a chair. There are wall-mounted lamps and a large window with curtains.

A reception area with a wooden reception desk, a wall-mounted clock, and a welcome mat.

A restaurant with multiple tables and chairs, a wooden counter, and a painting on the wall.

A Comfort Inn & Suites hotel with a brick facade, multiple windows, and a clear blue sky.

12. Comfort Inn & Suites Orangeburg

Orangeburg

$101

$112 total

includes taxes & fees

Nov 1 - Nov 2

A restaurant with round tables and chairs, a counter with a display case, and large windows.

A hotel room with two beds, a desk, and a mirror.

A kitchen with wooden cabinets, a stainless steel range hood, and a black refrigerator.

A reception desk with a laptop, a patterned sofa, and a doormat with "SOUTHERN" visible.

13. Southern Lodge 601

Orangeburg

$75

$83 total

includes taxes & fees

Oct 15 - Oct 16

A hotel room with a bed, a desk, a chair, a sofa, and a table.

A breakfast corner with wooden tables and chairs, a coffee machine, and a sign indicating breakfast hours.

A Baymont Inn & Suites reception desk with a sign indicating Orangeburg, South Carolina.

A gym with cardio equipment, dumbbells, and a TV on a shelf.

14. Baymont by Wyndham Orangeburg North

Orangeburg

$55

$61 total

includes taxes & fees

Oct 20 - Oct 21

A hotel room with a bed, a desk, a chair, and a hanging coat rack.

A room with two framed pictures on the wall, a table with a coffee machine, bowls, and a mug.

A modern kitchen with a granite countertop, a built-in microwave, a sink, and a mirror above the counter.

A spacious living area with a wooden floor, a ceiling fan, a flat-screen TV, and a large window with sheer curtains.

15. Suburban Studios Orangeburg

Orangeburg

$56

$62 total

includes taxes & fees

Oct 21 - Oct 22

A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

A lobby with two leather armchairs, a marble-topped table, and a patterned carpet.

16. Baymont by Wyndham Santee

Santee

$80

$89 total

includes taxes & fees

Oct 15 - Oct 16

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A hotel room with two beds, a desk, and a large window with a view.

A modern hotel lobby with a central reception desk, a children's play area, and a restaurant named "Top It Break."

A modern lobby with a blue sofa, teal chairs, and a wooden table.

17. Tru By Hilton Santee

Santee

$101

$112 total

includes taxes & fees

Nov 1 - Nov 2

A water park with a pool, slides, and umbrellas.

A modern lounge area with seating, tables, and a fireplace.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

A reception desk with a wooden panel backdrop and a neon sign.

18. Holiday Inn Santee by IHG

Santee

$100

$111 total

includes taxes & fees

Oct 18 - Oct 19

A hotel room with a sofa, a bed with a red blanket, two bedside lamps, a small table, and a TV.

A parking lot with multiple cars and a yellow truck.

A building with a covered entrance and a signboard.

A hotel room with a large bed, a desk, a chair, a TV, and a window with curtains.

19. Orangeburg Inn & Suites

Orangeburg

$54

$61 total

includes taxes & fees

Oct 25 - Oct 26

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A Hampton Inn hotel at night with a well-lit facade and a parking lot in the foreground.

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

20. Hampton Inn Santee-I-95

Santee

$118

$131 total

includes taxes & fees

Nov 3 - Nov 4

View all properties

Go beyond your typical stay in Saint Matthews

Learn more about Saint Matthews

The region around Saint Matthews is home to attractions such as Congaree National Park and Harry Hampton Visitor Center.

See all hotels in Saint Matthews

Check out reviews of Saint Matthews hotels guests love

Tru by Hilton Orangeburg

Orangeburg

10/10 Exceptional

Chad

Hampton Inn & Suites Orangeburg

Orangeburg

10/10 Exceptional

Kevin

Holiday Inn Express & Suites Orangeburg by IHG

Orangeburg

10/10 Exceptional

Deborah

Spark by Hilton Orangeburg

Orangeburg

10/10 Exceptional

Aaron

Fairfield Inn by Marriott Orangeburg

Orangeburg

10/10 Exceptional

Barry

Comfort Inn & Suites Orangeburg

Orangeburg

10/10 Exceptional

Ken

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

A multi-story hotel with a prominent sign, a covered entrance, and a parking lot.

A reception desk with a wooden panel wall and a circular decorative piece above it.

A modern restaurant with a central island, multiple seating areas, and a large window providing natural light.

Fairfield Inn & Suites by Marriott Santee

Santee

10/10 Exceptional

Choose this hotel for a pet-friendly stop-over on our drive to Florida and had a great experience. This staff was super-friendly and this nearly-brand-new property was immaculate. They have us a great 1st floor room with easy access to the walking and parking area. We took advantage of the patio to have dinner (take-out from a local restaurant) and breakfast with our dog. The breakfast was excellent, including hot omelets, eggs, and sausage, and the 6 am start (on a Sunday) allowed us to get...

Douglas

Tru By Hilton Santee

Santee

10/10 Exceptional

Rebecca

Hampton Inn Santee-I-95

Santee

10/10 Exceptional

Michael

Super 8 by Wyndham, Orangeburg

Orangeburg

10/10 Exceptional

An outdoor patio with a stone fire pit, seating, and a covered area with lights.

A modern reception area with a large digital display, a counter, and vending machines.

A modern kitchen with dark wood cabinets, a white countertop, and various kitchen appliances.

A hotel room with a modern design, featuring a large bed, a desk, and a seating area with a tray table.

Springhill Suites by Marriott Columbia near Fort Jackson

Columbia

10/10 Exceptional

Savannah

Suburban Studios Orangeburg

Orangeburg

10/10 Exceptional

Rhonda

A hotel entrance with a sign reading "Best Western PLISS."

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

Best Western Plus Santee Inn

Santee

10/10 Exceptional

Richard

Baymont by Wyndham Santee

Santee

10/10 Exceptional

Angel

Holiday Inn Santee by IHG

Santee

10/10 Exceptional

Catherine

Frequently Asked Questions

What hotels do travelers like in Saint Matthews?

Guests like Tru by Hilton Orangeburg.

Can I book a refundable hotel in Saint Matthews?

If you want the flexibility to change your travel plans to Saint Matthews, most hotels offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Saint Matthews be like during my trip?

July and August are typically the warmest months in Saint Matthews when the average temp is 79°F. January and February are the coldest months when the average temperature is 51°F. August and July are the months with the most rain.

Why should I book my Saint Matthews accommodation with Hotels.com?

There are lots of reasons to book your Saint Matthews trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.