Hotels in South Main
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Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,000 reviews)
The price is $79
$92 total
includes taxes & fees
Apr 6 - Apr 7

Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.0 out of 10, Good, (1,262 reviews)
The price is $93
$108 total
includes taxes & fees
Apr 5 - Apr 6

Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,007 reviews)
The price is $94
$110 total
includes taxes & fees
Mar 29 - Mar 30

Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,001 reviews)
The price is $68
$80 total
includes taxes & fees
Apr 26 - Apr 27

Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (844 reviews)
The price is $78
$91 total
includes taxes & fees
Apr 5 - Apr 6

La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd
La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd32 km from South Main
9.2 out of 10, Wonderful, (1,000 reviews)
The price is $71
$82 total
includes taxes & fees
Apr 5 - Apr 6

Sonesta Simply Suites Houston – NASA Clear Lake
Sonesta Simply Suites Houston – NASA Clear Lake31.8 km from South Main
8.0 out of 10, Very Good, (1,016 reviews)
The price is $55
$64 total
includes taxes & fees
Mar 29 - Mar 30

Studio 6 Deer Park, TX
Studio 6 Deer Park, TX28.7 km from South Main
9.4 out of 10, Exceptional, (409 reviews)
The price is $69
$81 total
includes taxes & fees
Apr 4 - Apr 5

GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown
GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown28.8 km from South Main
8.6 out of 10, Excellent, (666 reviews)
The price is $60
$69 total
includes taxes & fees
Mar 29 - Mar 30

Hampton Inn & Suites Houston/Clear Lake-Nasa Area
Hampton Inn & Suites Houston/Clear Lake-Nasa Area30.9 km from South Main
8.4 out of 10, Very Good, (1,000 reviews)
The price is $82
$96 total
includes taxes & fees
Apr 8 - Apr 9

Platinum Inn & Suites Webster
Platinum Inn & Suites Webster30.8 km from South Main
7.8 out of 10, Good, (1,003 reviews)
The price is $77
$89 total
includes taxes & fees
Mar 29 - Mar 30

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG30.8 km from South Main
9.0 out of 10, Wonderful, (1,001 reviews)
The price is $88
$103 total
includes taxes & fees
Apr 26 - Apr 27

Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,003 reviews)
The price is $82
$96 total
includes taxes & fees
Apr 5 - Apr 6

Home2 Suites by Hilton Houston Pasadena
Home2 Suites by Hilton Houston Pasadena24.3 km from South Main
9.4 out of 10, Exceptional, (847 reviews)
The price is $97
$113 total
includes taxes & fees
Apr 5 - Apr 6

Hotel Royale
Hotel Royale20.9 km from South Main
9.4 out of 10, Exceptional, (20 reviews)
The price is $81
$95 total
includes taxes & fees
Mar 29 - Mar 30

La Quinta Inn & Suites by Wyndham Houston Channelview
La Quinta Inn & Suites by Wyndham Houston ChannelviewNortheast Houston, 28.6 km from South Main
8.6 out of 10, Excellent, (887 reviews)
The price is $90
$105 total
includes taxes & fees
Apr 23 - Apr 24

Hampton Inn Houston I-10 East
Hampton Inn Houston I-10 East20.4 km from South Main
8.8 out of 10, Excellent, (575 reviews)
The price is $62
$73 total
includes taxes & fees
Apr 23 - Apr 24

Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook16.8 km from South Main
9.4 out of 10, Exceptional, (160 reviews)
The price is $109
$132 total
includes taxes & fees
Mar 29 - Mar 30

Fairfield Inn & Suites by Marriott Houston Hobby Airport.
Fairfield Inn & Suites by Marriott Houston Hobby Airport.Southeast Houston, 15.3 km from South Main
7.6 out of 10, Good, (1,006 reviews)
The price is $67
$78 total
includes taxes & fees
Mar 29 - Mar 30

Best Western Plus Hobby Airport Inn & Suites
Best Western Plus Hobby Airport Inn & Suites15.3 km from South Main
8.8 out of 10, Excellent, (1,474 reviews)
The price is $76
$89 total
includes taxes & fees
Apr 1 - Apr 2
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
![]() Wyndham Houston near NRG Park/Medical Center | 7.0 Good 1,262 reviews | View | ||||||
![]() Wingate Houston near NRG Park/Medical Center | 6.6 1,000 reviews | View | ||||||
![]() Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,007 reviews | View | ||||||
![]() Candlewood Suites Houston Medical Center by IHG | 7.4 Good 844 reviews | View | ||||||
![]() Quality Inn & Suites NRG Park - Medical Center | 6.6 1,001 reviews | View |
Check out reviews of South Main hotels guests love

Holiday Inn Houston Downtown by IHG
10/10 Excellent
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