Hotels in South Main

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Tonight
Oct 5 - Oct 6
Tomorrow
Oct 6 - Oct 7
This weekend
Oct 9 - Oct 11
Next weekend
Oct 16 - Oct 18

Where to stay in South Main?

A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.
A hotel room with a blue sofa, a desk with a lamp, a chair, a window with curtains, and two framed pictures on the wall.
A spacious lobby with a reception desk, two sofas, a coffee station, and large windows providing natural light.
A Comfort Suites hotel entrance with a covered walkway, a sign, and a parking area.

1. Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
South Main
United States
nancy
$80
$94 total
includes taxes & fees
Nov 1 - Nov 2
Comfort Suites Houston near Medical Center- NRG Stadium
A modern lobby with a blue carpet, seating area, and large windows.
A lobby with a bar area, leather seating, and a stone wall.
A spacious hall with a patterned carpet, a red curtain backdrop, and a grand chandelier.
A hotel room with two beds, a nightstand with lamps, a window with curtains, and a framed picture on the wall.

2. Wyndham Houston at Reliant Park & Medical Center

Wyndham Houston at Reliant Park & Medical Center
South Main
United States
Charmin
$98
$115 total
includes taxes & fees
Oct 11 - Oct 12
Wyndham Houston at Reliant Park & Medical Center
A hotel room with a blue sofa, striped armchair, a small table, a TV on a cabinet, a microwave, and a door leading to a bedroom.
A vending machine and a Coca-Cola refrigerator in a hallway with tiled flooring and a ceiling with fluorescent lights.
A hotel room with a large bed, two bedside tables, a nightstand, a mirror, and a window with curtains.
A self-service breakfast bar with a coffee machine, cereal dispensers, and a refrigerated display.

3. Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
South Main
United States
HERBERT
$68
$80 total
includes taxes & fees
Oct 29 - Oct 30
Quality Inn & Suites NRG Park - Medical Center
A spacious lobby with a central seating area, a bar, and a reception desk.
A spacious indoor dining area with multiple tables and chairs, large windows, and hanging pendant lights.
A modern living room with a fireplace, sofas, and a flat-screen TV.
A hotel room with a large bed, bedside lamps, a TV, a dresser, and a painting on the wall.

4. Wingate Houston near Reliant Park/Medical Center

Wingate Houston near Reliant Park/Medical Center
South Main
United States
Miguel
$99
$116 total
includes taxes & fees
Oct 11 - Oct 12
Wingate Houston near Reliant Park/Medical Center
A compact kitchen with dark cabinets, a microwave, a coffee maker, and a white countertop. There are two wicker chairs and a small table.
A hotel room with a dining table, a sofa, a TV, and a kitchen area.
A compact kitchen with a dining table, chairs, a coffee maker, and a refrigerator.
A neatly made bed with a patterned bedspread, two bedside lamps, and a nightstand with a small item on it.

5. Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
South Main
United States
Barbara
$74
$87 total
includes taxes & fees
Oct 11 - Oct 12
Candlewood Suites Houston Medical Center by IHG
A glass door leading to an outdoor seating area with wicker furniture and cushions.
A modern residential building with a swimming pool, multiple balconies, and a covered outdoor area.
A parking area with covered parking spaces and a chain-link fence.
A covered patio area with wicker furniture, a table, and a chair.

6. 3 BR Condo near Reliant/NRG Stadium

3 BR Condo near Reliant/NRG Stadium
South Main
$128
$389 total
includes taxes & fees
Oct 6 - Oct 7
3 BR Condo near Reliant/NRG Stadium
A spacious dining area with multiple tables and chairs, large windows, and hanging pendant lights.
A coffee station with two coffee machines and a variety of coffee pods and cups.
A Holiday Inn Express & Suites hotel with a glass entrance, multiple floors, and a view of the surrounding neighborhood.
A hotel room with a bed, a desk, a chair, a sofa, and a TV.

7. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
1.4 km from South Main
United States
Juan
$129
$152 total
includes taxes & fees
Oct 8 - Oct 9
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
A bar area with a long counter, bar stools, a refrigerated display case with beverages, and a menu board above the counter.
A hotel pool area with a bar, seating, and a view of the building's exterior.
A GoBoard® displaying the time, weather, and news.
A modern living room with a sectional sofa, a round coffee table, and a comfortable seating area with armchairs.

8. Courtyard By Marriott Houston Medical Center Reliant Park

Courtyard By Marriott Houston Medical Center Reliant Park
2.7 km from South Main
United States
Vicki
$121
$143 total
includes taxes & fees
Oct 11 - Oct 12
Courtyard By Marriott Houston Medical Center Reliant Park
A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.
A hotel room with a large bed, a flat-screen TV, a painting on the wall, and a view of the city through large windows.
A spacious indoor area with high ceilings, large windows, and modern furniture.
A modern bar area with a long counter, multiple bar stools, and a variety of bottles and glasses.

9. Hyatt House Houston Medical Center

Hyatt House Houston Medical Center
Texas Medical Center, 3.1 km from South Main
United States
Kathleen
$134
$158 total
includes taxes & fees
Oct 11 - Oct 12
Hyatt House Houston Medical Center
A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.
A multi-story hotel with a rooftop pool area, featuring a modern design and multiple balconies.
A spacious indoor area with high ceilings, large windows, and modern furniture.
A modern reception area with a wooden reception desk, a coffee machine, and a seating area with a sofa and armchairs.

10. Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center
Texas Medical Center, 3.1 km from South Main
United States
Elizabeth
$126
$149 total
includes taxes & fees
Oct 11 - Oct 12
Hyatt Place Houston Medical Center
A modern restaurant with a bar area, wooden flooring, and a variety of seating options including tables and chairs.
A living room with a black leather sofa, a round coffee table with a vase, and a patterned rug.
A hotel room with a bed, a desk, a chair, a TV, and a wardrobe.
A modern interior with a seating area, a bar with a green wall, and a window with artwork.

11. Hotel Ylem

Hotel Ylem
2.3 km from South Main
United States
Sheradon
$81
$100 total
includes taxes & fees
Oct 18 - Oct 19
Hotel Ylem
A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.
A modern bar area with a long counter, multiple seating options, and a variety of liquor bottles on shelves.
A modern lobby with seating areas, a reception desk, and decorative wall art.
A dining table set with plates, cutlery, glasses, and candles, surrounded by chairs in a formal dining area.

12. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
Texas Medical Center, 4.4 km from South Main
United Kingdom
Gary
$100
$119 total
includes taxes & fees
Oct 11 - Oct 12
Hilton Houston Plaza/Medical Center
A rooftop pool area with lounge chairs and a view of a tall building at night.
A modern hotel lobby with a bar area, seating arrangements, and a reception desk.
A modern hotel lobby with wooden flooring, contemporary chairs, and illuminated ceiling panels.
A modern hotel with a prominent glass facade, a flat roof, and a ground-level entrance with a covered walkway.

13. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
Texas Medical Center, 4.4 km from South Main
United States
Fuller
$145
$180 total
includes taxes & fees
Oct 11 - Oct 12
The Westin Houston Medical Center/Museum District
A person sitting on a white lounge chair with a striped towel, reading a book.
A hotel lobby with a modern design, featuring a reception desk, seating area, and a large window.
A bar area with a long counter, multiple shelves with bottles, and a television screen.
A hotel room with a large bed, a bench, a television, and a window with a city view.

14. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Crowne Plaza Houston Med Ctr-Galleria Area by IHG
Greenway Plaza-Upper Kirby, 6.5 km from South Main
United States
Kristian
$69
$81 total
includes taxes & fees
Oct 6 - Oct 7
Crowne Plaza Houston Med Ctr-Galleria Area by IHG
A reception area with a wooden reception desk, two refrigerators, and clocks displaying different city names.
A hotel room with two beds, a desk with a chair, a television, and a mirror.
A modern kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a built-in oven.
A modern hotel lobby with a bar area, seating arrangements, and artwork on the walls.

15. Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
Southeast Houston, 10.2 km from South Main
United States
Quyen
$83
$97 total
includes taxes & fees
Oct 11 - Oct 12
Best Western Plus Pearland/Houston Medical Center Hotel
A spacious living area with a dining table, chairs, and a chandelier.
A modern hotel room with a large window, a sofa, a coffee table, and a dining area.
A restaurant with tables set for dining, surrounded by wicker chairs and potted plants.
A high-rise hotel with a rooftop pool, multiple floors, and a city skyline in the background.

16. Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
6.3 km from South Main
United States
jaci
$276
$370 total
includes taxes & fees
Oct 8 - Oct 9
Hotel Zaza Houston Museum District
A hotel pool area with a pool, lounge chairs, and umbrellas.
A lobby with a round glass table, green chairs, a fireplace, and a reception desk.
A hotel lobby with a bar area, seating, and a television screen.
A Hilton Garden Inn with a green roof, multiple floors, and a central entrance.

17. Hilton Garden Inn Houston-Pearland

Hilton Garden Inn Houston-Pearland
10.6 km from South Main
United States
Deirdra
$88
$100 total
includes taxes & fees
Oct 12 - Oct 13
Hilton Garden Inn Houston-Pearland
A hotel entrance with a covered walkway, a 'No Parking' sign, and a 'Home 2 Suites by Hilton' sign.
A hotel room with a kitchenette, a bed, a bathroom, and a view of the hallway.
An indoor swimming pool with lounge chairs and yellow chairs around it.
A modern outdoor seating area with colorful striped cushions and a round orange ottoman.

18. Home2 Suites by Hilton at the Galleria

Home2 Suites by Hilton at the Galleria
Greater Uptown, 8 km from South Main
United States
Marcela
$106
$124 total
includes taxes & fees
Oct 26 - Oct 27
Home2 Suites by Hilton at the Galleria
A spacious lobby with a central dining area, seating arrangements, and a large flat-screen TV.
An outdoor patio area with a stone floor, orange cushioned seating, and a pergola structure.
An indoor swimming pool with clear water, a tiled floor, and a pool ladder.
A hotel reception desk with a welcome sign, a minibar, and a sign indicating the hotel is part of the Lone Star State chain.

19. Hampton Inn & Suites Houston Heights I-10

Hampton Inn & Suites Houston Heights I-10
Washington Ave./ Memorial Park, 11.8 km from South Main
United States
Dwight
$106
$124 total
includes taxes & fees
Oct 30 - Oct 31
Hampton Inn & Suites Houston Heights I-10
A hotel lobby with a hot tub, a pool, and a dining area.
A hotel lobby with a reception desk, seating area, and a television mounted on the wall.
A hotel room with a large bed, a desk with a TV, a chair, a lamp, and a cityscape painting on the wall.
A hotel lobby with a central dining area, multiple seating options, and a visible market sign.

20. Drury Inn & Suites Houston Near the Galleria

Drury Inn & Suites Houston Near the Galleria
The Galleria, 9.4 km from South Main
United States
Juan
$102
$119 total
includes taxes & fees
Oct 11 - Oct 12
Drury Inn & Suites Houston Near the Galleria
View all properties

Compare popular hotels in South Main

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.
Comfort Suites Houston near Medical Center- NRG Stadium
8.8
Excellent
1,001 reviews
View
A compact kitchen with dark cabinets, a microwave, a coffee maker, and a white countertop. There are two wicker chairs and a small table.
Candlewood Suites Houston Medical Center by IHG
7.4
Good
897 reviews
View
A modern lobby with a blue carpet, seating area, and large windows.
Wyndham Houston at Reliant Park & Medical Center
7.2
Good
1,429 reviews
View
A hotel room with a blue sofa, striped armchair, a small table, a TV on a cabinet, a microwave, and a door leading to a bedroom.
Quality Inn & Suites NRG Park - Medical Center
6.6
Good
1,001 reviews
View
A spacious lobby with a central seating area, a bar, and a reception desk.
Wingate Houston near Reliant Park/Medical Center
6.6
Good
1,004 reviews
View
Our prices for hotels in South Main are cheapest in August
Price trends for hotels in South Main
Pricing is based on two traveler single night rates
View properties in October
Typical weather for Houston
October
High 28°C / low 19°C. Sunny most days.
View properties in October
28°
19°
22°
13°
18°
10°
17°
8°
19°
10°
23°
14°
26°
17°
30°
21°
33°
24°
34°
25°
34°
26°
32°
23°
Monthly weather averages (˚C)

Check out reviews of South Main hotels guests love

Wyndham Houston at Reliant Park & Medical Center

Wyndham Houston at Reliant Park & Medical Center

10/10 Excellent
"M"
Katia 1-night trip
Posted 2 hours ago
Wyndham Houston at Reliant Park & Medical Center
Courtyard by Marriott Houston Intercontinental Airport

Courtyard by Marriott Houston Intercontinental Airport

8/10 Good
"Nice and clean and very convenient"
Brockley T 4-night trip
Posted 6 hours ago
Courtyard by Marriott Houston Intercontinental Airport
Grand Tuscany Hotel

Grand Tuscany Hotel

10/10 Excellent
"Dry nice weekend stay. Staff very accommodating"
Valerie 2-night trip
Posted 8 hours ago
Grand Tuscany Hotel
Hyatt Regency Houston West

Hyatt Regency Houston West

10/10 Excellent
"The water was not hot enough"
Chimere 1-night trip
Posted 9 hours ago
Hyatt Regency Houston West
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

10/10 Excellent
"Good location and great amenities"
Marsha 2-night trip
Posted 10 hours ago
The Westin Houston Medical Center/Museum District
The Whitehall Houston

The Whitehall Houston

10/10 Excellent
"We absolutely loved it. It was really nice!! The staff were very, very pleasant."
Latoya 1-night trip
Posted 12 hours ago
The Whitehall Houston
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

10/10 Excellent
"All of the staff went above and beyond to accommodate me and my travel companions and were so friendly and helpful. Very clean property and rooms, near shopping and plenty of food options. I’m definitely staying at this hotel on all Houston trips going forward!"
Jaimie 3-night trip
Posted 12 hours ago
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Hyatt Place Houston/Galleria

Hyatt Place Houston/Galleria

10/10 Excellent
"Excellent location and modern hotel."
CARLOS 1-night trip
Posted 1 day ago
Hyatt Place Houston/Galleria
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