Hotels in South Main
Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices
Check prices for these dates
Top 5 hotels in South Main at a glance
- Wyndham Houston near NRG Park/Medical Center ā 3.5-star hotel in South Main. Guest rating: 7.2/10 ā Good.
- Comfort Suites Houston near Medical Center- NRG Stadium ā 2.5-star hotel in South Main. Guest rating: 8.8/10 ā Excellent.
- Wingate Houston near NRG Park/Medical Center ā 3-star hotel in South Main. Guest rating: 6.6/10.
- Quality Inn & Suites NRG Park - Medical Center ā 2.5-star hotel in South Main. Guest rating: 6.6/10.
- Candlewood Suites Houston Medical Center by IHG ā 2.5-star hotel in South Main. Guest rating: 7.4/10 ā Good.
Where to stay in South Main?
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,379 reviews)
"Itās walking distance to NRG stadium. The staff was wonderful."
Dana
The price is $77
$90 total
includes taxes & fees
Sep 1 - Sep 2
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.8 out of 10, Excellent, (1,001 reviews)
"Great location close to nrg stadium rooms were good and breakfast was great"
Lona
The price is $97
$114 total
includes taxes & fees
Sep 1 - Sep 2
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,003 reviews)
"Good location next to the stadium"
Eric
The price is $74
$87 total
includes taxes & fees
Aug 5 - Aug 6
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,009 reviews)
"Room was clean, bed was comfortable, breakfast was good. Perfect place to stay for going to NRG Stadium as itās an easy walk"
Daniel
The price is $59
$69 total
includes taxes & fees
Sep 1 - Sep 2
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (889 reviews)
"Everything was clean and the staff was helpful. Close to lots of restaurants and had a shuttle to the stadium."
Barbara
The price is $74
$87 total
includes taxes & fees
Aug 27 - Aug 28
Hyatt Place Houston Medical Center
Hyatt Place Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2,606 reviews)
"We thoroughly enjoyed our stay! The room was perfect. The breakfast was amazing. The staff was great. Super nice hotel!!"
Marcus
The price is $126
$149 total
includes taxes & fees
Aug 9 - Aug 10
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG1.4 km from South Main
9.4 out of 10, Exceptional, (1,009 reviews)
"Checked all the boxes. From being walking distance to NRG to great breakfast choices. Will use this hotel for any NRG activities or events nearby."
Coach
The price is $118
$139 total
includes taxes & fees
Aug 6 - Aug 7
Blossom Hotel Houston, Curio Collection by Hilton
Blossom Hotel Houston, Curio Collection by HiltonTexas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3,848 reviews)
"The location was great for medical campuses and NRG Stadium. Property was clean and attractive. Staff was friendly especially valet. Room was large and comfortable. Bathroom was large with good shower."
Suzanne
The price is $147
$172 total
includes taxes & fees
Aug 8 - Aug 9
Hyatt House Houston Medical Center
Hyatt House Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1,263 reviews)
"It was very comfortable stay !"
estella
The price is $121
$143 total
includes taxes & fees
Aug 9 - Aug 10
The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum DistrictTexas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,162 reviews)
"Clean room. Friendly Staff. Great location to jump on metro to NRG Stadium"
Ruben
The price is $152
$189 total
includes taxes & fees
Aug 8 - Aug 9
Hilton Garden Inn Houston Medical Center, TX
Hilton Garden Inn Houston Medical Center, TXTexas Medical Center, 4.7 km from South Main
9.2 out of 10, Wonderful, (1,003 reviews)
"Breakfast buffet was amazing!"
Darren
The price is $114
$133 total
includes taxes & fees
Aug 9 - Aug 10
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (377 reviews)
"The staff is always friendly and helpful."
Sharon
The price is $89
$104 total
includes taxes & fees
Aug 4 - Aug 5
Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical CenterTexas Medical Center, 4.4 km from South Main
8.4 out of 10, Very Good, (2,071 reviews)
"Excellent stay while there for a tournament near NRG. Perfect location. The staff was so wonderful! "
Lindsy
The price is $82
$97 total
includes taxes & fees
Aug 16 - Aug 17
Home2 Suites by Hilton at the Galleria
Home2 Suites by Hilton at the GalleriaGreater Uptown, 8 km from South Main
9.0 out of 10, Wonderful, (1,009 reviews)
"It's was outstanding room 609 nice, very very clean breakfast was great and the staff was nice and sweet and helpful Love all of it."
Kevin
The price is $106
$124 total
includes taxes & fees
Aug 9 - Aug 10
Hotel Ylem
Hotel Ylem2.3 km from South Main
8.4 out of 10, Very Good, (1,543 reviews)
"Itās a small hotel but in a great location. Shopping is close by and lots of food choices nearby. It would be an ideal place to stay during football season. NRG stadium is very close! You could walk there if you wanted to."
Carolyn
The price is $78
$96 total
includes taxes & fees
Aug 12 - Aug 13
DoubleTree by Hilton Hotel Houston - Greenway Plaza
DoubleTree by Hilton Hotel Houston - Greenway PlazaGreenway Plaza-Upper Kirby, 6.6 km from South Main
8.4 out of 10, Very Good, (1,780 reviews)
"really nice staff, super helpful, not one complaint to give."
Nicole
The price is $81
$95 total
includes taxes & fees
Aug 15 - Aug 16
Drury Inn & Suites Houston Near the Galleria
Drury Inn & Suites Houston Near the GalleriaThe Galleria, 9.4 km from South Main
9.4 out of 10, Exceptional, (1,496 reviews)
"The amenities are great, nice clean hotel and the team couldnāt be more proficient and kind. They made my stay a very nice and comfortable one."
Karen
The price is $90
$105 total
includes taxes & fees
Aug 9 - Aug 10
Best Western Plus Downtown Inn & Suites
Best Western Plus Downtown Inn & Suites10.2 km from South Main
9.2 out of 10, Wonderful, (1,112 reviews)
"Good stay
Clean room
Helpful staff"
Karen
The price is $118
$138 total
includes taxes & fees
Aug 9 - Aug 10
Hyatt Place Houston/Galleria
Hyatt Place Houston/Galleria8.7 km from South Main
8.8 out of 10, Excellent, (1,560 reviews)
"location was good and stay"
desiree
The price is $111
$131 total
includes taxes & fees
Aug 5 - Aug 6
Studio 6 Houston, TX ā Pearland/Medical Center
Studio 6 Houston, TX ā Pearland/Medical CenterSoutheast Houston, 12.9 km from South Main
9.2 out of 10, Wonderful, (174 reviews)
"Very nice, and clean. Comfortable and quiet"
Pamela
The price is $60
$70 total
includes taxes & fees
Aug 9 - Aug 10
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.8 Excellent 1,001 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,003 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.2 Good 1,379 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 889 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,009 reviews | View |
Check out reviews of South Main hotels guests love
Marriott Marquis Houston
10/10 Excellent
Find out more about South Main