Hotels in South Main
Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices
Check prices for these dates
Tonight
Sep 13 - Sep 14Tomorrow
Sep 14 - Sep 15Next weekend
Sep 18 - Sep 20In two weeks
Sep 25 - Sep 27Where to stay in South Main?
1. Wyndham Houston at Reliant Park & Medical Center
Wyndham Houston at Reliant Park & Medical CenterSouth Main
Luis
$94
$110 total
includes taxes & fees
Sep 24 - Sep 25
2. Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
LaKeisha
$95
$111 total
includes taxes & fees
Sep 21 - Sep 22
3. Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
HERBERT
$67
$79 total
includes taxes & fees
Oct 12 - Oct 13
4. Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
Barbara
$78
$91 total
includes taxes & fees
Sep 21 - Sep 22
5. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG1.4 km from South Main
Juan
$118
$139 total
includes taxes & fees
Sep 17 - Sep 18
6. Hyatt Place Houston Medical Center
Hyatt Place Houston Medical CenterTexas Medical Center, 3.1 km from South Main
Eduardo
$127
$149 total
includes taxes & fees
Oct 5 - Oct 6
7. Hyatt House Houston Medical Center
Hyatt House Houston Medical CenterTexas Medical Center, 3.1 km from South Main
Michael
$134
$158 total
includes taxes & fees
Sep 28 - Sep 29
8. Courtyard By Marriott Houston Medical Center Reliant Park
Courtyard By Marriott Houston Medical Center Reliant Park2.7 km from South Main
Gregory
$112
$132 total
includes taxes & fees
Sep 17 - Sep 18
9. Hotel Ylem
Hotel Ylem2.3 km from South Main
Bettie
$73
$91 total
includes taxes & fees
Sep 22 - Sep 23
10. Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical CenterTexas Medical Center, 4.4 km from South Main
Jaimee
$106
$125 total
includes taxes & fees
Oct 11 - Oct 12
11. Hilton Garden Inn Houston Medical Center, TX
Hilton Garden Inn Houston Medical Center, TXTexas Medical Center, 4.7 km from South Main
Amy
$114
$133 total
includes taxes & fees
Sep 24 - Sep 25
12. Blossom Hotel Houston, Curio Collection by Hilton
Blossom Hotel Houston, Curio Collection by HiltonTexas Medical Center, 3.5 km from South Main
Samantha
$163
$192 total
includes taxes & fees
Sep 20 - Sep 21
13. Home2 Suites by Hilton Houston Medical Center, TX
Home2 Suites by Hilton Houston Medical Center, TXTexas Medical Center, 4.7 km from South Main
Jason
$130
$153 total
includes taxes & fees
Sep 25 - Sep 26
14. The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum DistrictTexas Medical Center, 4.4 km from South Main
Fuller
$137
$170 total
includes taxes & fees
Sep 27 - Sep 28
15. Hotel Zaza Houston Museum District
Hotel Zaza Houston Museum District6.3 km from South Main
April
$276
$362 total
includes taxes & fees
Sep 14 - Sep 15
16. Crowne Plaza Houston Med Ctr-Galleria Area by IHG
Crowne Plaza Houston Med Ctr-Galleria Area by IHGGreenway Plaza-Upper Kirby, 6.5 km from South Main
Lakesha
$71
$84 total
includes taxes & fees
Sep 17 - Sep 18
17. DoubleTree by Hilton Hotel Houston - Greenway Plaza
DoubleTree by Hilton Hotel Houston - Greenway PlazaGreenway Plaza-Upper Kirby, 6.6 km from South Main
Nicole
$89
$105 total
includes taxes & fees
Sep 24 - Sep 25
18. Holiday Inn Express Houston - Galleria Area by IHG
Holiday Inn Express Houston - Galleria Area by IHGThe Galleria, 8.6 km from South Main
Mireya
$127
$149 total
includes taxes & fees
Sep 20 - Sep 21
19. Spark by Hilton Houston near the Galleria
Spark by Hilton Houston near the Galleria9.6 km from South Main
Sophia
$84
$98 total
includes taxes & fees
Sep 21 - Sep 22
20. Best Western Plus Downtown Inn & Suites
Best Western Plus Downtown Inn & Suites10.2 km from South Main
Michael
$116
$136 total
includes taxes & fees
Sep 24 - Sep 25
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet friendly | WiFi included |
|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.8 Excellent 1,000 reviews | View | |||||
 Wyndham Houston at Reliant Park & Medical Center | 7.2 Good 1,404 reviews | View | |||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 896 reviews | View | |||||
 Wingate Houston at Reliant Park & Medical Center | 6.6 1,001 reviews | View | |||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,001 reviews | View |
Our prices for hotels in South Main are cheapest in August
Our prices for hotels in South Main are cheapest in August
Price trends for hotels in South Main
Pricing is based on two traveler single night rates
Check out reviews of South Main hotels guests love
Hilton Houston Plaza/Medical Center
10/10 Excellent
"Staff was very kind and helpful"
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
8/10 Good
"Excellent service from all angles. Made me feel at home."
Wyndham Houston at Reliant Park & Medical Center
8/10 Good
"The best thing about this was the location. We attended the AC/DC concert and this hotel was within walking distance. I would only stay if attending an event at the Reliant Staduim. Not bad, but not the best."
Find out more about South Main