Hotels in South Main
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Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,003 reviews)
The price is $79
$92 total
includes taxes & fees
Apr 6 - Apr 7

Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.0 out of 10, Good, (1,266 reviews)
The price is $95
$111 total
includes taxes & fees
Apr 12 - Apr 13

Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,002 reviews)
The price is $68
$79 total
includes taxes & fees
Apr 26 - Apr 27

Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,000 reviews)
The price is $99
$116 total
includes taxes & fees
Mar 29 - Mar 30

Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (844 reviews)
The price is $78
$91 total
includes taxes & fees
Apr 5 - Apr 6

Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG1.4 km from South Main
9.4 out of 10, Exceptional, (1,004 reviews)
The price is $125
$147 total
includes taxes & fees
Apr 3 - Apr 4

Hyatt House Houston Medical Center
Hyatt House Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1,253 reviews)
The price is $127
$149 total
includes taxes & fees
Apr 5 - Apr 6

Hyatt Place Houston Medical Center
Hyatt Place Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2,427 reviews)
The price is $126
$149 total
includes taxes & fees
Apr 5 - Apr 6

Hampton Inn & Suites Houston Medical Center NRG Park
Hampton Inn & Suites Houston Medical Center NRG ParkTexas Medical Center, 3 km from South Main
8.4 out of 10, Very Good, (1,000 reviews)
The price is $99
$117 total
includes taxes & fees
Apr 5 - Apr 6

Hilton Garden Inn Houston Medical Center, TX
Hilton Garden Inn Houston Medical Center, TXTexas Medical Center, 4.7 km from South Main
9.2 out of 10, Wonderful, (1,001 reviews)
The price is $107
$125 total
includes taxes & fees
Apr 5 - Apr 6

Blossom Hotel Houston, Curio Collection by Hilton
Blossom Hotel Houston, Curio Collection by HiltonTexas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3,740 reviews)
The price is $158
$185 total
includes taxes & fees
Apr 26 - Apr 27

DoubleTree by Hilton Hotel Houston - Greenway Plaza
DoubleTree by Hilton Hotel Houston - Greenway Plaza6.6 km from South Main
8.4 out of 10, Very Good, (1,526 reviews)
The price is $115
$135 total
includes taxes & fees
Apr 4 - Apr 5

Sonesta ES Suites Houston Galleria
Sonesta ES Suites Houston GalleriaThe Galleria, 8.4 km from South Main
8.4 out of 10, Very Good, (1,199 reviews)
The price is $93
$108 total
includes taxes & fees
Mar 29 - Mar 30

Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.2 out of 10, Wonderful, (194 reviews)
The price is $89
$104 total
includes taxes & fees
Mar 31 - Apr 1

The Royal Sonesta Houston Galleria
The Royal Sonesta Houston GalleriaThe Galleria, 8.8 km from South Main
8.6 out of 10, Excellent, (1,722 reviews)
The price is $144
$168 total
includes taxes & fees
Apr 4 - Apr 5

Home2 Suites by Hilton at the Galleria
Home2 Suites by Hilton at the GalleriaGreater Uptown, 8 km from South Main
9.0 out of 10, Wonderful, (1,003 reviews)
The price is $115
$134 total
includes taxes & fees
Apr 12 - Apr 13

The Whitehall Houston
The Whitehall HoustonHouston Central Business District, 10 km from South Main
8.6 out of 10, Excellent, (2,071 reviews)
The price is $143
$167 total
includes taxes & fees
Apr 5 - Apr 6

Hyatt Place Houston/Galleria
Hyatt Place Houston/Galleria8.7 km from South Main
8.8 out of 10, Excellent, (1,409 reviews)
The price is $135
$159 total
includes taxes & fees
Apr 5 - Apr 6

Hampton Inn Houston-Near The Galleria
Hampton Inn Houston-Near The GalleriaThe Galleria, 9.1 km from South Main
8.0 out of 10, Very Good, (1,005 reviews)
The price is $92
$108 total
includes taxes & fees
Apr 12 - Apr 13

Hyatt Regency Houston/Galleria
Hyatt Regency Houston/Galleria8.7 km from South Main
9.2 out of 10, Wonderful, (1,285 reviews)
The price is $169
$199 total
includes taxes & fees
Mar 29 - Mar 30
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
![]() Quality Inn & Suites NRG Park - Medical Center | 6.6 1,002 reviews | View | ||||||
![]() Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,000 reviews | View | ||||||
![]() Candlewood Suites Houston Medical Center by IHG | 7.4 Good 844 reviews | View | ||||||
![]() Wyndham Houston near NRG Park/Medical Center | 7.0 Good 1,266 reviews | View | ||||||
![]() Wingate Houston near NRG Park/Medical Center | 6.6 1,003 reviews | View |
Check out reviews of South Main hotels guests love

Hyatt Regency Houston West
10/10 Excellent
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