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Hotels in South San Francisco

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Where to stay in South San Francisco?

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

When is the best time to visit South San Francisco?

Our prices for hotels in South San Francisco are cheapest in December
Price trends for hotels in South San Francisco
Pricing is based on two traveler single night rates
View properties in January
Currently viewing crowd sizes and weather for January.
Typical weather for South San Francisco
January
High 14°C / low 9°C. Sunny most days.
View properties in January
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January, no crowd data, average high temperature 14 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
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February, no crowd data, average high temperature 15 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
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March, no crowd data, average high temperature 15 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
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April, no crowd data, average high temperature 16 degrees Celsius, average low temperature 10 degrees Celsius. Sunny most days.
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May, no crowd data, average high temperature 17 degrees Celsius, average low temperature 11 degrees Celsius. Sunny most days.
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June, no crowd data, average high temperature 19 degrees Celsius, average low temperature 13 degrees Celsius. Sunny most days.
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July, no crowd data, average high temperature 19 degrees Celsius, average low temperature 13 degrees Celsius. Sunny most days.
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August, no crowd data, average high temperature 20 degrees Celsius, average low temperature 14 degrees Celsius. Sunny most days.
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September, no crowd data, average high temperature 20 degrees Celsius, average low temperature 15 degrees Celsius. Sunny most days.
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October, no crowd data, average high temperature 19 degrees Celsius, average low temperature 14 degrees Celsius. Sunny most days.
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November, no crowd data, average high temperature 17 degrees Celsius, average low temperature 11 degrees Celsius. Sunny most days.
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December, no crowd data, average high temperature 14 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
Monthly weather averages (˚C)

Top neighborhoods in South San Francisco

Downtown South San Francisco

Downtown South San Francisco buzzes with a blend of biotech innovation and cultural diversity. Corporate towers and colorful murals tell the story of this unique business hub. You'll find authentic taquerias, dim sum houses, and Filipino eateries nestled between modern office campuses along Grand Avenue. The neighborhood comes alive during weekdays when professionals fill its plazas and restaurants. Getting around is a breeze with nearby BART and Caltrain stations connecting you to San Francisco proper and beyond. Business hotels cater mostly to corporate travelers with practical amenities. The area quiets down after work hours, offering a genuine glimpse into Bay Area life away from tourist crowds.

Oyster Point

Oyster Point balances sleek biotech campuses with stunning San Francisco Bay views. The waterfront promenade offers perfect spots for watching waves crash against the shore or catching a beautiful sunset. Modern plazas feature public art installations while walking paths showcase both cutting-edge architecture and natural bay ecosystems. Business travelers appreciate the corporate hotels with meeting facilities and convenient access to office buildings. Dining options cater primarily to weekday lunch crowds, with most establishments closing early evening. The area is best explored by car, though waterfront paths provide scenic strolling opportunities away from the corporate hustle.

The East Side

The East Side delivers authentic local life away from San Francisco's tourist traps. Catch Bay views from San Bruno Point Park or explore diverse family-owned restaurants along Grand Avenue serving up killer tacos and pho. This residential neighborhood mixes Hispanic and Asian influences that shine through local markets and casual eateries. Budget travelers appreciate the affordable motels and extended-stay options that cost way less than downtown San Francisco. Buses connect to BART and Caltrain, though having wheels helps. Most spots close early, so plan your food adventures accordingly.

Paradise Valley

Paradise Valley offers a peaceful retreat from San Francisco's bustle while keeping you close to the action. This quiet residential neighborhood in South San Francisco balances suburban calm with convenient access to nearby attractions. Take a stroll through San Bruno Point Park or venture to local spots like K1 Speed for some indoor racing fun. Budget-friendly accommodations make Paradise Valley an appealing base for Bay Area exploration. The neighborhood's proximity to San Francisco International Airport and major highways ensures easy connections throughout the region. With ample street parking and minimal crowds, you'll appreciate this low-key alternative to the city's more hectic districts.

Serra Highlands

Serra Highlands offers a peaceful retreat from the Bay Area buzz with its hillside streets and family-friendly vibe. While there aren't tourist attractions within the neighborhood itself, you'll enjoy stunning panoramic views, quiet walking paths, and easy access to nearby highlights like Serramonte Center. Morning fog rolling over the hills creates a mystical atmosphere worth waking up for. Getting around requires a car or rideshare, as public transit is limited in this residential area. Accommodations consist mainly of vacation rental homes with suburban comforts like driveways and yards. For dining and shopping, you'll need to venture to surrounding commercial areas, making Serra Highlands perfect for travelers seeking authentic local living.

Top landmarks in South San Francisco

Learn more about South San Francisco

Look beyond the iconic 'South San Francisco The Industrial City' sign crowning Sign Hill Park for a city with its own distinct identity. Grand Avenue serves up a global feast of family-run eateries where locals debate the merits of each dumpling house. San Bruno Mountain offers hiking trails with sweeping Bay views that explain why residents tolerate the fog. See's Candies factory tours satisfy sweet tooths, while K1 Speed delivers indoor racing thrills. The Convention Center hosts events that draw visitors who are surprised to discover this isn't simply San Francisco's southern neighborhood. Despite tripling in population since World War II, 'South City' maintains its working-class roots while embracing its role as a Peninsula destination in its own right.

#BVSBlue Aristodes Demetries, One Of Americas Best Known Sculptors Created This Steel Sculpture As A Symbol Of Cabot Cabot And Forbes Industrial Park. Situated 243 Feet Above Sea Level It Rises To A Be Seen From The Bay Bridge, The East Bay and SFO. Called The Wind Harp Locally. It emits eerie sounds when the wind 💨is at its strongest.
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Open Photo by Tonette Pineda✈⛵🚌🚉🚃🚅🚀

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Frequently asked questions

What accommodations do travelers like in South San Francisco?
Can I book refundable accommodations in South San Francisco?
If you need the flexibility to change your travel plans to South San Francisco, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow down the results.
Where can I stay in South San Francisco if I want a vacation rental instead of a hotel?
If you're looking for a good alternative to a hotel, review our selection of 32 vacation homes. In addition, you can choose from 11 apartments.
What will the weather in South San Francisco be like during my visit?
The warmest months in South San Francisco are usually September and August with an average temp of 62°F. February and January are the chilliest months when the average temp is 53°F. The rainiest months are December and January.
Why should I book my South San Francisco accommodation with Hotels.com?
There are lots of reasons to book your South San Francisco trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.