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Hotels in South San Francisco

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DoubleTree by Hilton San Francisco South Airport Blvd
DoubleTree by Hilton San Francisco South Airport Blvd
4.0 star property
South San Francisco
8.4 out of 10, Very Good, (2,096 reviews)
  • cleanliness
    Quiet airport sanctuary with free shuttle service and fitness center for travelers.
The price is $103
$121 total
includes taxes & fees
Jan 30 - Jan 31
DoubleTree by Hilton San Francisco South Airport Blvd
Sonesta Select San Francisco Airport Oyster Point Waterfront
Sonesta Select San Francisco Airport Oyster Point Waterfront
3.0 star property
Oyster Point
8.6 out of 10, Excellent, (1,950 reviews)
  • cleanliness
    Experience a waterfront stay minutes from SFO with 24-hour fitness center access.
The price is $100
$120 total
includes taxes & fees
Jan 25 - Jan 26
Sonesta Select San Francisco Airport Oyster Point Waterfront
Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
3.0 star property
Oyster Point
8.4 out of 10, Very Good, (1,005 reviews)
  • cleanliness
    Unwind near San Francisco Bay with airport shuttle and outdoor pool access.
The price is $101
$120 total
includes taxes & fees
Jan 24 - Jan 25
Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
Best Western Plus Grosvenor Airport Hotel
Best Western Plus Grosvenor Airport Hotel
3.0 star property
South San Francisco
8.4 out of 10, Very Good, (1,734 reviews)
  • cleanliness
    Stay close to the airport with a free shuttle and enjoy nearby San Francisco attractions.
The price is $109
$128 total
includes taxes & fees
Feb 13 - Feb 14
Best Western Plus Grosvenor Airport Hotel
AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
4.0 star property
Oyster Point
9.2 out of 10, Wonderful, (1,002 reviews)
  • cleanliness
    Waterfront escape just minutes from SFO with indoor pool and local cuisine.
The price is $134
$160 total
includes taxes & fees
Jan 31 - Feb 1
AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
Hilton Garden Inn San Francisco Arpt North
Hilton Garden Inn San Francisco Arpt North
3.0 star property
The East Side
8.6 out of 10, Excellent, (1,000 reviews)
  • cleanliness
    Serene South San Francisco stay near shopping and transit, ideal for exploring.
The price is $98
$115 total
includes taxes & fees
Jan 30 - Jan 31
Hilton Garden Inn San Francisco Arpt North
Embassy Suites by Hilton San Francisco Airport Oyster Point
Embassy Suites by Hilton San Francisco Airport Oyster Point
3.5 star property
The East Side
8.6 out of 10, Excellent, (1,270 reviews)
  • cleanliness
    Convenient airport hotel with free breakfast near SF transit options.
The price is $147
$172 total
includes taxes & fees
Jan 29 - Jan 30
Embassy Suites by Hilton San Francisco Airport Oyster Point
Hampton Inn San Francisco Airport
Hampton Inn San Francisco Airport
2.5 star property
The East Side
8.6 out of 10, Excellent, (1,007 reviews)
The price is $113
$134 total
includes taxes & fees
Jan 25 - Jan 26
Hampton Inn San Francisco Airport
La Quinta Inn & Suites by Wyndham San Francisco Airport N
La Quinta Inn & Suites by Wyndham San Francisco Airport N
3.0 star property
Downtown South San Francisco
8.0 out of 10, Very Good, (2,021 reviews)
  • cleanliness
    Perfect for a quiet stay near San Francisco Airport with free shuttle service.
The price is $101
$119 total
includes taxes & fees
Jan 25 - Jan 26
La Quinta Inn & Suites by Wyndham San Francisco Airport N
Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area
Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area
2.5 star property
The East Side
9.0 out of 10, Wonderful, (451 reviews)
  • cleanliness
    Stylish South San Francisco stay with free airport shuttles and minutes to SFO.
The price is $121
$142 total
includes taxes & fees
Jan 30 - Jan 31
Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area
Home2 Suites by Hilton San Francisco Airport North
Home2 Suites by Hilton San Francisco Airport North
3.0 star property
The East Side
8.8 out of 10, Excellent, (1,180 reviews)
  • cleanliness
    Modern hotel with free breakfast near SFO, plus easy access to downtown spots.
The price is $118
$138 total
includes taxes & fees
Jan 31 - Feb 1
Home2 Suites by Hilton San Francisco Airport North
Hotel Nova SFO
Hotel Nova SFO
2.5 star property
South San Francisco
8.6 out of 10, Excellent, (1,005 reviews)
The price is $105
$123 total
includes taxes & fees
Jan 24 - Jan 25
Hotel Nova SFO
Four Points by Sheraton Hotel & Suites San Francisco Airport
Four Points by Sheraton Hotel & Suites San Francisco Airport
3.0 star property
South San Francisco
7.8 out of 10, Good, (1,001 reviews)
  • cleanliness
    Convenient business stay near Moscone with fitness options and free WiFi.
The price is $91
$107 total
includes taxes & fees
Jan 25 - Jan 26
Four Points by Sheraton Hotel & Suites San Francisco Airport
Holiday Inn Express San Francisco-Airport North by IHG
Holiday Inn Express San Francisco-Airport North by IHG
2.5 star property
South San Francisco
8.2 out of 10, Very Good, (1,007 reviews)
  • cleanliness
    Convenient South San Francisco hotel offers quick airport access and daily breakfast.
The price is $85
$100 total
includes taxes & fees
Jan 24 - Jan 25
Holiday Inn Express San Francisco-Airport North by IHG
Larkspur Landing Extended Stay Suites South San Francisco
Larkspur Landing Extended Stay Suites South San Francisco
3.0 star property
The East Side
7.8 out of 10, Good, (1,000 reviews)
  • cleanliness
    Quiet extended stay retreat in South San Francisco with complimentary breakfast.
The price is $106
$125 total
includes taxes & fees
Jan 25 - Jan 26
Larkspur Landing Extended Stay Suites South San Francisco
Travelodge by Wyndham San Francisco Airport North
Travelodge by Wyndham San Francisco Airport North
2.0 star property
South San Francisco
5.8 out of 10, (3,095 reviews)
  • cleanliness
    Close to the airport with pool and free shuttle for quick San Francisco access.
The price is $60
$72 total
includes taxes & fees
Jan 25 - Jan 26
Travelodge by Wyndham San Francisco Airport North
Hotel Focus SFO
Hotel Focus SFO
3.0 star property
The East Side
7.6 out of 10, Good, (1,529 reviews)
  • cleanliness
    Quick access to SFO with convenient complimentary shuttle and free breakfast.
The price is $86
$101 total
includes taxes & fees
Jan 24 - Jan 25
Hotel Focus SFO
Airport Inn
Airport Inn
2.0 star property
Downtown South San Francisco
8.8 out of 10, Excellent, (979 reviews)
  • cleanliness
    Close to SFO, this straightforward motel offers free parking and Wi-Fi access.
The price is $110
$129 total
includes taxes & fees
Jan 24 - Jan 25
Airport Inn
Deluxe Inn
Deluxe Inn
2.5 star property
South San Francisco
8.2 out of 10, Very Good, (240 reviews)
  • cleanliness
    Cozy stay in South San Francisco with free WiFi and parking for urban explorers.
The price is $90
$106 total
includes taxes & fees
Jan 24 - Jan 25
Deluxe Inn
Inn By The SFO
Inn By The SFO
2.0 star property
Downtown South San Francisco
7.8 out of 10, Good, (1,001 reviews)
  • cleanliness
    Quiet and convenient near SFO, with helpful staff and free parking.
The price is $89
$105 total
includes taxes & fees
Jan 24 - Jan 25
Inn By The SFO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Check out pet-friendly hotels in South San Francisco

You may also like hotels with pools in South San Francisco

You can also stay at family-friendly hotels in South San Francisco

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

When is the best time to visit South San Francisco?

Our prices for hotels in South San Francisco are cheapest in December
Price trends for hotels in South San Francisco
Pricing is based on two traveler single night rates
View properties in January
Currently viewing crowd sizes and weather for January.
Typical weather for South San Francisco
January
High 14°C / low 9°C. Sunny most days.
View properties in January
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January, no crowd data, average high temperature 14 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
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February, no crowd data, average high temperature 15 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
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March, no crowd data, average high temperature 15 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
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April, no crowd data, average high temperature 16 degrees Celsius, average low temperature 10 degrees Celsius. Sunny most days.
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May, no crowd data, average high temperature 17 degrees Celsius, average low temperature 11 degrees Celsius. Sunny most days.
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June, no crowd data, average high temperature 19 degrees Celsius, average low temperature 13 degrees Celsius. Sunny most days.
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July, no crowd data, average high temperature 19 degrees Celsius, average low temperature 13 degrees Celsius. Sunny most days.
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August, no crowd data, average high temperature 20 degrees Celsius, average low temperature 14 degrees Celsius. Sunny most days.
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September, no crowd data, average high temperature 20 degrees Celsius, average low temperature 15 degrees Celsius. Sunny most days.
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October, no crowd data, average high temperature 19 degrees Celsius, average low temperature 14 degrees Celsius. Sunny most days.
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November, no crowd data, average high temperature 17 degrees Celsius, average low temperature 11 degrees Celsius. Sunny most days.
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December, no crowd data, average high temperature 14 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
Monthly weather averages (˚C)

Top neighborhoods in South San Francisco

Downtown South San Francisco

Downtown South San Francisco buzzes with a blend of biotech innovation and cultural diversity. Corporate towers and colorful murals tell the story of this unique business hub. You'll find authentic taquerias, dim sum houses, and Filipino eateries nestled between modern office campuses along Grand Avenue. The neighborhood comes alive during weekdays when professionals fill its plazas and restaurants. Getting around is a breeze with nearby BART and Caltrain stations connecting you to San Francisco proper and beyond. Business hotels cater mostly to corporate travelers with practical amenities. The area quiets down after work hours, offering a genuine glimpse into Bay Area life away from tourist crowds.

Oyster Point

Oyster Point balances sleek biotech campuses with stunning San Francisco Bay views. The waterfront promenade offers perfect spots for watching waves crash against the shore or catching a beautiful sunset. Modern plazas feature public art installations while walking paths showcase both cutting-edge architecture and natural bay ecosystems. Business travelers appreciate the corporate hotels with meeting facilities and convenient access to office buildings. Dining options cater primarily to weekday lunch crowds, with most establishments closing early evening. The area is best explored by car, though waterfront paths provide scenic strolling opportunities away from the corporate hustle.

The East Side

The East Side delivers authentic local life away from San Francisco's tourist traps. Catch Bay views from San Bruno Point Park or explore diverse family-owned restaurants along Grand Avenue serving up killer tacos and pho. This residential neighborhood mixes Hispanic and Asian influences that shine through local markets and casual eateries. Budget travelers appreciate the affordable motels and extended-stay options that cost way less than downtown San Francisco. Buses connect to BART and Caltrain, though having wheels helps. Most spots close early, so plan your food adventures accordingly.

Paradise Valley

Paradise Valley offers a peaceful retreat from San Francisco's bustle while keeping you close to the action. This quiet residential neighborhood in South San Francisco balances suburban calm with convenient access to nearby attractions. Take a stroll through San Bruno Point Park or venture to local spots like K1 Speed for some indoor racing fun. Budget-friendly accommodations make Paradise Valley an appealing base for Bay Area exploration. The neighborhood's proximity to San Francisco International Airport and major highways ensures easy connections throughout the region. With ample street parking and minimal crowds, you'll appreciate this low-key alternative to the city's more hectic districts.

Serra Highlands

Serra Highlands offers a peaceful retreat from the Bay Area buzz with its hillside streets and family-friendly vibe. While there aren't tourist attractions within the neighborhood itself, you'll enjoy stunning panoramic views, quiet walking paths, and easy access to nearby highlights like Serramonte Center. Morning fog rolling over the hills creates a mystical atmosphere worth waking up for. Getting around requires a car or rideshare, as public transit is limited in this residential area. Accommodations consist mainly of vacation rental homes with suburban comforts like driveways and yards. For dining and shopping, you'll need to venture to surrounding commercial areas, making Serra Highlands perfect for travelers seeking authentic local living.

Top landmarks in South San Francisco

Learn more about South San Francisco

Look beyond the iconic 'South San Francisco The Industrial City' sign crowning Sign Hill Park for a city with its own distinct identity. Grand Avenue serves up a global feast of family-run eateries where locals debate the merits of each dumpling house. San Bruno Mountain offers hiking trails with sweeping Bay views that explain why residents tolerate the fog. See's Candies factory tours satisfy sweet tooths, while K1 Speed delivers indoor racing thrills. The Convention Center hosts events that draw visitors who are surprised to discover this isn't simply San Francisco's southern neighborhood. Despite tripling in population since World War II, 'South City' maintains its working-class roots while embracing its role as a Peninsula destination in its own right.

#BVSBlue Aristodes Demetries, One Of Americas Best Known Sculptors Created This Steel Sculpture As A Symbol Of Cabot Cabot And Forbes Industrial Park. Situated 243 Feet Above Sea Level It Rises To A Be Seen From The Bay Bridge, The East Bay and SFO. Called The Wind Harp Locally. It emits eerie sounds when the wind 💨is at its strongest.
Photo by Tonette Pineda✈⛵🚌🚉🚃🚅🚀
Open Photo by Tonette Pineda✈⛵🚌🚉🚃🚅🚀

Check out reviews of South San Francisco hotels guests love

Frequently asked questions

What accommodations do travelers like in South San Francisco?
Can I book refundable accommodations in South San Francisco?
If you need the flexibility to change your travel plans to South San Francisco, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow down the results.
Where can I stay in South San Francisco if I want a vacation rental instead of a hotel?
If you're looking for a good alternative to a hotel, review our selection of 32 vacation homes. In addition, you can choose from 11 apartments.
What will the weather in South San Francisco be like during my visit?
The warmest months in South San Francisco are usually September and August with an average temp of 62°F. February and January are the chilliest months when the average temp is 53°F. The rainiest months are December and January.
Why should I book my South San Francisco accommodation with Hotels.com?
There are lots of reasons to book your South San Francisco trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.