Business Hotels in Panama City

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight
Aug 28 - Aug 29
Tomorrow
Aug 29 - Aug 30
This weekend
Aug 28 - Aug 30
Next weekend
Sep 4 - Sep 6

Business Hotels in Panama City

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
Bella Vista
$132
$145 total
includes taxes & fees
Sep 28 - Sep 29
Hotel Riu Plaza Panama

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG
Tocumen
$126
$145 total
includes taxes & fees
Sep 27 - Sep 28
Crowne Plaza Panama Airport by IHG

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
San Antonio
$101
$111 total
includes taxes & fees
Sep 5 - Sep 6
Courtyard by Marriott Panama Metromall

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo
Casco Viejo
$183
$202 total
includes taxes & fees
Sep 27 - Sep 28
Central Hotel Panama Casco Viejo

Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica
San Francisco
$109
$120 total
includes taxes & fees
Sep 5 - Sep 6
Ramada Plaza by Wyndham Panama Punta Pacifica

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
San Francisco
$103
$114 total
includes taxes & fees
Sep 28 - Sep 29
Plaza Paitilla Inn Hotel

Principe Hotel and Suites

Principe Hotel and Suites
Bella Vista
$59
$65 total
includes taxes & fees
Aug 31 - Sep 1
Principe Hotel and Suites

The Executive Hotel

The Executive Hotel
Bella Vista
$89
$98 total
includes taxes & fees
Sep 6 - Sep 7
The Executive Hotel

JW Marriott Panama

JW Marriott Panama
San Francisco
$263
$290 total
includes taxes & fees
Sep 20 - Sep 21
JW Marriott Panama

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
Casco Viejo
$351
$386 total
includes taxes & fees
Sep 19 - Sep 20
Sofitel Legend Casco Viejo, Panama City

The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
Veracruz
$197
$217 total
includes taxes & fees
Sep 25 - Sep 26
The Westin Playa Bonita Panama

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama
San Francisco
$152
$168 total
includes taxes & fees
Sep 6 - Sep 7
Las Americas Golden Tower Panama

Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall
San Francisco
$118
$130 total
includes taxes & fees
Sep 6 - Sep 7
Courtyard by Marriott Panama Multiplaza Mall

Megapolis Hotel Panamá

Megapolis Hotel Panamá
San Francisco
$133
$133 total
includes taxes & fees
Sep 3 - Sep 4
Megapolis Hotel Panamá

Decapolis Hotel Panama City

Decapolis Hotel Panama City
San Francisco
$112
$124 total
includes taxes & fees
Sep 27 - Sep 28
Decapolis Hotel Panama City

Hyatt Regency Panama City

Hyatt Regency Panama City
Bella Vista
$200
$220 total
includes taxes & fees
Aug 29 - Aug 30
Hyatt Regency Panama City

Hilton Panama

Hilton Panama
Bella Vista
$237
$261 total
includes taxes & fees
Sep 18 - Sep 19
Hilton Panama

Renaissance Panama City Hotel

Renaissance Panama City Hotel
Bella Vista
$127
$140 total
includes taxes & fees
Sep 3 - Sep 4
Renaissance Panama City Hotel

Radisson Hotel Panama Canal

Radisson Hotel Panama Canal
Amador
$94
$104 total
includes taxes & fees
Aug 31 - Sep 1
Radisson Hotel Panama Canal

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
Bella Vista
$155
$171 total
includes taxes & fees
Aug 29 - Aug 30
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
See more properties

Top neighborhoods in Panama City

Casco Viejo

Casco Viejo's cobblestone streets tell Panama's colonial story at every turn. The golden Metropolitan Cathedral and historic theaters create a living museum vibe. Rooftop bars offer spectacular bay views while museums showcase Panama's diverse heritage. Plaza hopping rewards you with hidden architectural gems and cultural performances that bring history to life. The neighborhood serves up everything from fusion cuisine in restored mansions to traditional Panamanian dishes. Boutique hotels occupy colonial buildings with charming courtyards and personalized service. Though compact, comfortable walking shoes are essential for navigating the uneven historic streets.

Bella Vista

Bella Vista balances Panama City's sleek business side with upscale urban living. Gleaming skyscrapers along Avenida Balboa house financial headquarters while trendy spots on Calle Uruguay buzz with after-work crowds. Shop at MultiPlaza Pacific mall, visit Crown Casino, or simply stroll the waterfront promenade for stunning bay views. Getting around is a breeze with two metro stations and plentiful taxis. Dining options range from rooftop restaurants to international cuisine that won't disappoint. High-rise hotels with spectacular views cater to business travelers and tourists who appreciate modern comforts with a side of ocean breeze.

El Cangrejo

El Cangrejo pulses with modern energy around the iconic "El Tornillo" tower, where art meets business in Panama City's cosmopolitan heart. Korean BBQ aromas mingle with coffee scents from sidewalk cafes, while galleries showcase local talent beneath tropical sunshine. Colorful murals splash across office buildings as diverse cultures blend in this trendy district. The neighborhood serves up an eclectic fusion of Korean, Jewish, and Panamanian cuisines in stylish eateries and casual cafes. Modern boutique hotels and upscale business lodging dominate accommodation options. Getting around is a breeze with nearby Metro Line 1 stations, abundant taxis, and pleasantly walkable streets.

Obarrio

Obarrio dazzles with gleaming skyscrapers housing Panama City's financial powerhouses and luxury shopping. Multiplaza Pacific mall tempts with designer boutiques while the business crowd buzzes between meetings. When you're not trying your luck at local casinos, relax at a sophisticated coffeehouse or stroll the wide, clean sidewalks of Calle 50. Hotels range from international chains to boutique properties, with rates reflecting the upscale surroundings. Getting around is a breeze with excellent taxi service, frequent buses along Via España, and the Metro Line 1 connecting directly to Iglesia del Carmen station.

Punta Pacifica

Punta Pacifica's gleaming glass towers and an iconic sail-shaped skyscraper create a skyline that screams luxury with a Pacific Ocean backdrop. Stroll the waterfront promenades where swaying palms frame perfect sunset views, or duck into Multiplaza Pacific Mall to browse designer boutiques in marble-floored splendor. The neighborhood balances business and pleasure with its mix of corporate offices and upscale leisure spots. Dining here means international cuisine with ocean views at rooftop bars and hotel restaurants where reservations are smart moves. High-rise hotels and serviced apartments offer amenities like infinity pools and concierge services. Getting around is easy with abundant taxis and walkable streets, though you won't find much public transit in this polished enclave.

Top landmarks in Panama City

A modern building facade with vertical reflective panels and the word "GUCCI" prominently displayed.
Photo by Fabiola Tile

Multiplaza Pacific Mall

9.0/10 (4,497 reviews)
If you want to give your credit card some exercise, head out to Multiplaza Pacific Mall in San Francisco. Splash some more cash at Avenida Balboa, Multicentro Panama, and Pacific Center.
See properties
A marina with numerous boats, a bridge in the background, and lush green hills.

Amador Causeway

9.0/10 (1,902 reviews)
If you're planning a bit of sightseeing head to Amador Causeway— just one of the monuments in Amador. You can also discover the cathedral and churches in the area— your sightseeing tour starts here. It's also full of great shops and restaurants, so you can spend the afternoon having a wander.
See properties
A city skyline with tall buildings along a waterfront.
Photo by Rob Gosse

Cinta Costera

9.2/10 (3,823 reviews)
Cinta Costera is worth a pic or two when discovering Calidonia.
See properties
A nighttime cityscape with illuminated skyscrapers and a river reflecting the lights.

Avenida Balboa

8.8/10 (3,608 reviews)
If you want to give your credit card some exercise, head out to Avenida Balboa in Calidonia. Splash some more cash at Multicentro Panama, Uruguay Street, and Multiplaza Pacific Mall.
See properties
A historic stone tower amidst ruins, surrounded by grassy terrain.

Panama Viejo

9.2/10 (3,752 reviews)
If you're planning a bit of sightseeing head to Panama Viejo— just one of the monuments in Parque Lefevre. It's also full of great shops and restaurants, so you can spend the afternoon having a wander.
See properties

Albrook Shopping Mall

8.6/10 (4,561 reviews)
Don't visit Ancon without stopping off at Albrook Shopping Mall, a top spot for shopaholics. It's also full of great shops and restaurants, so you can spend the afternoon having a wander.
See properties

Via Espana

8.4/10 (2,902 reviews)
If you want to give your credit card some exercise, head out to Via Espana in Bella Vista. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. Splash some more cash at Uruguay Street, Multicentro Panama, and Avenida Balboa.
See properties

Fuerte Amador Resort & Marina

9.4/10 (169 reviews)
You can stroll along Fuerte Amador Resort & Marina for relaxing water views when you're in Amador. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. If you carry on walking you'll get to Panama Cruise Terminal for some more water views.
See properties