Hotels logo

Hotels in Jackson

September 2026
11
October 2026

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

This weekend
Sep 11 - Sep 13
Next weekend
Sep 18 - Sep 20

Where to stay in Jackson?

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.
A restaurant with a brick wall, a flat-screen TV, and a bar area.
A hotel room with two beds, a brick wall, and a wooden headboard.

1. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
$85
$90 total
includes taxes & fees
Sep 20 - Sep 21
Drury Inn & Suites Jackson MO
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
An outdoor patio with tables and chairs, a stone wall, and large windows.
A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.
A hotel room with two beds, a nightstand, a lamp, and a chair.

2. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
$93
$100 total
includes taxes & fees
Sep 13 - Sep 14
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A spacious lobby with large windows, comfortable seating, and a modern ceiling design.
A room with large windows, two red upholstered chairs, a small table, and a potted plant.
A breakfast bar with coffee machines, a cereal dispenser, and a fruit display.
A hotel room with a bed, a dark sofa, an ottoman, a lamp, and artwork on the wall.

3. Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
Jackson
$80
$86 total
includes taxes & fees
Oct 4 - Oct 5
Comfort Suites Jackson-Cape Girardeau
A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.
A bathroom with a granite countertop sink, a mirror, two hair dryers mounted on the wall, and a trash bin.
A trophy labeled "Town House Inn" with "Cape Girardeau County, Missouri" and "2025" on it.

4. Town House Inn

Town House Inn
Jackson
$71
$77 total
includes taxes & fees
Sep 13 - Sep 14
Town House Inn
A modern retail area with a display of local items and snacks.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.
A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

5. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau
$89
$102 total
includes taxes & fees
Sep 20 - Sep 21
Tru By Hilton Cape Girardeau
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

6. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
$100
$113 total
includes taxes & fees
Sep 20 - Sep 21
Drury Plaza Hotel Cape Girardeau Conference Center
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.
A Dear Tree Inn building with a covered entrance and a clear sky at dusk.
A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

7. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
$72
$81 total
includes taxes & fees
Sep 20 - Sep 21
Pear Tree Inn Cape Girardeau West
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

8. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
$90
$102 total
includes taxes & fees
Sep 20 - Sep 21
Drury Inn & Suites Cape Girardeau
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

9. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
$101
$115 total
includes taxes & fees
Sep 20 - Sep 21
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.
A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.
A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

10. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
$101
$114 total
includes taxes & fees
Sep 20 - Sep 21
Fairfield Inn & Suites by Marriott Cape Girardeau
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
An outdoor patio with stone walls, wicker furniture, and large windows.
A gym with exercise equipment, a treadmill, and a wall-mounted TV.
A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.

11. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
$106
$119 total
includes taxes & fees
Sep 20 - Sep 21
Hampton Inn Cape Girardeau I 55 East
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.
A hotel room with two beds, a desk, a chair, and a view of the city.
A modern outdoor seating area with a glass-top table and a fire feature, overlooking a sunset view.

12. The Riverview

The Riverview
Cape Girardeau
$114
$129 total
includes taxes & fees
Sep 13 - Sep 14
The Riverview
A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.
A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.
A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.
A reception desk with a green wall, a wooden door, and a sign that reads 'QUALITY INN.'

13. Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
Cape Girardeau
$59
$67 total
includes taxes & fees
Sep 20 - Sep 21
Quality Inn Cape Girardeau North
A spacious lobby with marble flooring, elegant seating, and a grand staircase.
A spacious living room with a sofa set, a coffee table, and a dining area.
A lobby with seating areas, a reception desk, and a bar.
A Courtyard by Marriott hotel with a modern brick facade, large windows, and a covered entrance area.

14. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
Cape Girardeau
$125
$142 total
includes taxes & fees
Sep 20 - Sep 21
Courtyard by Marriott Cape Girardeau Downtown
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.
A hotel room with a bed, a TV, a desk, and a chair.
A hotel entrance with a large tree, a well-maintained garden with various plants and flowers, and a parking lot.
An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.

15. Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
Cape Girardeau
$88
$105 total
includes taxes & fees
Oct 4 - Oct 5
Candlewood Suites Cape Girardeau by IHG
A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.
A hotel room with a large bed, two bedside tables, a nightstand, a telephone, and two wall-mounted lamps.
A bathroom with a marble wall and a white bathtub.
A motel with multiple floors, a parking lot, and a staircase leading to the upper floors.

16. Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
Cape Girardeau
$75
$88 total
includes taxes & fees
Sep 17 - Sep 18
Town House Inn Cape Giradreau
A living room with a blue wall, a fireplace, a sofa, and a chair.
A bar area with stools and a counter where a bartender is serving drinks.
A hotel room with two beds, a vanity with a mirror, a chair, and a dresser.
A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.

17. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
Marble Hill
$84
$92 total
includes taxes & fees
Sep 12 - Sep 13
EC Reed's Mercantile and Hotel
A rustic cabin-style lodging with a covered porch, picnic tables, and a fire pit.
A playground with a wooden playhouse, a slide, and two animal-shaped swings.
A swimming pool with a small water slide, surrounded by lounge chairs and umbrellas.
A cabin interior with a kitchenette, a ceiling fan, a television, a sofa, and a window with blinds.

18. Perryville RV Resort

Perryville RV Resort
Perryville
$66
$76 total
includes taxes & fees
Sep 13 - Sep 14
Perryville RV Resort
A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.
A hotel room with a kitchenette, a large mirror, a sofa, and a patterned carpet.
A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.
A spacious lobby with a checkered floor, two sofas with patterned cushions, a computer desk, and a reception area with a glass door.

19. Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville
Perryville
$71
$81 total
includes taxes & fees
Sep 20 - Sep 21
Super 8 by Wyndham Perryville
A compact kitchen with wooden cabinets, a microwave, a trash bin, and a dining table with placemats.
A bedroom with a large bed, a ceiling fan, a TV, and a wall sign reading "Blue Line Resort".
A two-story wooden cabin with a balcony, a front door, and a staircase leading to the entrance.
A gravel path leading to a lake with cabins and a sign indicating Blue Line Resort.

20. Pet Friendly! Couples Retreat in Southern Illinois

Pet Friendly! Couples Retreat in Southern Illinois
Murphysboro
$120
$235 total
includes taxes & fees
Sep 13 - Sep 14
Pet Friendly! Couples Retreat in Southern Illinois
View all properties

Go beyond your typical stay in Jackson

pet friendly image
Pet friendly
Pet friendly
Pool image
Pool
Pool
hot tub image
Hot tub
Hot tub
spa image
Spa
Spa
Family friendly image
Family friendly
Family friendly
apart-hotel image
Apart hotel
Apart hotel
Cottage image
Cottage
Cottage
Our prices for hotels in Jackson are cheapest in December

Price trends for hotels in Jackson

Pricing is based on two traveler single night rates
View properties in September

September

High 28°C / low 17°C. Sunny most days.
28°
17°
21°
10°
13°
4°
8°
1°
5°
-2°
8°
-1°
14°
4°
19°
9°
24°
15°
30°
20°
32°
21°
31°
20°
Monthly weather averages (˚C)

Top landmarks in Jackson

Litz Park

8.6/10 (14 reviews)
Litz Park is worth a visit, located 0.8 mi (1.3 km) from central Jackson.
See properties

Indian Creek Wild Area

Indian Creek Wild Area is 11.2 mi (18 km) from central Jackson, why not stop by during your stay.
See properties

Lake Boutin

Lake Boutin is 11 mi (17.6 km) from central Jackson, why not stop by during your stay.
See properties

Vancill Hollow Natural Area

Vancill Hollow Natural Area is 11.6 mi (18.7 km) from central Jackson, why not stop by during your stay.
See properties

Learn more about Jackson

Jackson is well-known for its attractions such as Trail of Tears State Park and Mississippi River. This family-friendly city has something for everyone including restaurants as well as sights like Lake Boutin and Indian Creek Wild Area. All are within a rural setting.

See all hotels in Jackson
A historic building with a dome and columns, surrounded by trees and a paved walkway.

Check out reviews of Jackson hotels guests love

A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.
A bathroom with a granite countertop sink, a mirror, two hair dryers mounted on the wall, and a trash bin.
A trophy labeled "Town House Inn" with "Cape Girardeau County, Missouri" and "2025" on it.

Town House Inn

Town House Inn
Jackson

10/10 Exceptional

United States
larry
Town House Inn
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.
A restaurant with a brick wall, a flat-screen TV, and a bar area.
A hotel room with two beds, a brick wall, and a wooden headboard.

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson

10/10 Exceptional

United States
Nicole
Drury Inn & Suites Jackson MO
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
An outdoor patio with tables and chairs, a stone wall, and large windows.
A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.
A hotel room with two beds, a nightstand, a lamp, and a chair.

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson

10/10 Exceptional

United States
Alexandra
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A hotel room with two beds, a desk, a chair, a TV, and a projector screen.
A conference room with tables, chairs, a flat-screen TV, and a sign indicating amenities.
A reception area with two reception desks, a wall-mounted sign, and a refrigerator.
A buffet with various food items, including omelets and other dishes, with clear signage indicating the type of food.

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Murphysboro

10/10 Exceptional

United States
Sharra
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
A modern retail area with a display of local items and snacks.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.
A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau

10/10 Exceptional

United States
James
Tru By Hilton Cape Girardeau
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau

10/10 Exceptional

United States
Janet
Drury Plaza Hotel Cape Girardeau Conference Center
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau

10/10 Exceptional

United States
StephM
Drury Inn & Suites Cape Girardeau
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau

10/10 Exceptional

United States
David
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.
A Dear Tree Inn building with a covered entrance and a clear sky at dusk.
A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau

10/10 Exceptional

United States
Kimberly
Pear Tree Inn Cape Girardeau West
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
An outdoor patio with stone walls, wicker furniture, and large windows.
A gym with exercise equipment, a treadmill, and a wall-mounted TV.
A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau

10/10 Exceptional

United States
Reese
Hampton Inn Cape Girardeau I 55 East
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.
A hotel room with two beds, a desk, a chair, and a view of the city.
A modern outdoor seating area with a glass-top table and a fire feature, overlooking a sunset view.

The Riverview

The Riverview
Cape Girardeau

10/10 Exceptional

United States
Mark
The Riverview
A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.
A building with a sign that reads "The Atrium Boutique Hotel".
A building with a dark exterior, a large window, and a sign that reads "The Atrium."
A bedroom with a brick wall, a bed with patterned bedding, and a shelf with decorative items.

The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
Perryville

10/10 Exceptional

United States
James
The Atrium - A Boutique Hotel
A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.
A hallway with exposed brick walls, wooden flooring, and a white door.
A bedroom with a bed, a bench, a ceiling fan, a mirror, and a wooden floor.
A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

Urban Lofts

Urban Lofts
Perryville

10/10 Exceptional

United States
Gregory
Urban Lofts

Frequently Asked Questions

What accommodations do travelers like in Jackson?

Guests like La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau, Drury Inn & Suites Jackson MO and Comfort Suites Jackson-Cape Girardeau.

Can I book a refundable hotel in Jackson?

If you need the flexibility to change your travel plans to Jackson, most properties offer refundable* rates you can book. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.

Where should I consider staying in Jackson if I'm looking for a budget-friendly accommodation?

Comfort Suites Jackson-Cape Girardeau is an accommodation you might want to consider that'll save you money.

Where can I stay in Jackson if I want a vacation home instead of a hotel?

Browse 5 vacation homes on our site.

What will the weather in Jackson be like during my visit?

July and August are typically the warmest months in Jackson when the average temp is 76°F. January and February are the coldest months when the average temperature is 40°F. April and March are the months with the most rain.

Why should I book my Jackson hotel through Hotels.com?

There are lots of reasons to book your Jackson trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.