Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices
Check prices for these dates
Frequently Asked Questions
Can I book refundable accommodations in Santo Tomé?
If you're looking for the flexibility to change your travel plans to Santo Tomé, most properties offer refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in Santo Tomé be like during my vacation?
January and February are typically the warmest months in Santo Tomé when the average temp is 78°F. July and June are the coldest months when the average temperature is 60°F. October and November are the months with the most rain.
Why should I book my Santo Tomé hotel through Hotels.com?
There are lots of reasons to book your Santo Tomé trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.