My partner and I have stayed at many many Hoxtons throughout Europe. It is always our preference given the Hoxtons are always situated in the perfect location. However in this instance it is not. This Hoxton is located with the red light district of Brussels, Schaerbeek. Please be warned it is not safe! Muggings and harassment are at an all time high. My partner and I were harassed and almost mugged on entry to the hotel, as in right outside, and when reported to the hotel they were un-phased.
Please do not use Brussels Noord station as that is also in the heart of a very dangerous area.
Our advise would be to stay somewhere more central, Ixelles is a safe bet or European quarter.
If you do decide to stay my only advice would be to avoid travelling to and from by foot when it is dark, so from 5pm onwards.