Hotels in Wapello

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight
May 11 - May 12
Tomorrow
May 12 - May 13
This weekend
May 15 - May 17
Next weekend
May 22 - May 24

Where to stay in Wapello?

Premium bedding, iron/ironing board, free WiFi, bed sheets
Strawberry Farm Bed & Breakfast
Strawberry Farm Bed & Breakfast
3.0 star property
Muscatine
9.4 out of 10, Exceptional, (28 reviews)
Wake up to cooked-to-order breakfast at this charming Muscatine retreat. Enjoy hiking trails along the Mississippi River, then unwind in the garden or terrace. Free WiFi and parking make exploration easy, with Geneva Golf and Discovery Park nearby.
The price is $162
$181 total
includes taxes & fees
May 12 - May 13
Strawberry Farm Bed & Breakfast
Desk, iron/ironing board, free WiFi, bed sheets
Best Western Mt. Pleasant Inn
Best Western Mt. Pleasant Inn
2.5 star property
Mount Pleasant
8.2 out of 10, Very Good, (821 reviews)
Unwind at this tranquil hotel set in an open field where the indoor pool and poolside bar offer relaxation. Near Mt. Pleasant Station, the clean rooms include microwaves and fridges for added convenience.
The price is $78
$87 total
includes taxes & fees
May 18 - May 19
Best Western Mt. Pleasant Inn
House (1 Bedroom) | Interior
Idyllic Biggsville Vacation Rental: 10 Mi to River
Idyllic Biggsville Vacation Rental: 10 Mi to River
3.0 star property
Biggsville
10.0 out of 10, Exceptional, (3 reviews)
Experience country charm in this cozy cottage with free parking and air conditioning. Located near the Horse and Buggy Museum and Dutton Lake, you're just a short drive from Burlington Station and Southeast Iowa Regional Airport.
The price is $104
$203 total
includes taxes & fees
May 12 - May 13
Idyllic Biggsville Vacation Rental: 10 Mi to River
Lobby
AmericInn by Wyndham Mount Pleasant
AmericInn by Wyndham Mount Pleasant
3.0 star property
Mount Pleasant
8.6 out of 10, Excellent, (573 reviews)
Wake up to a delicious free breakfast at this convenient hotel with an indoor pool and fitness center. Located near Mt. Pleasant Station and local libraries, this quiet retreat offers free WiFi and parking with exceptionally helpful staff ready to assist.
The price is $84
$94 total
includes taxes & fees
May 17 - May 18
AmericInn by Wyndham Mount Pleasant
Double Room, 2 Double Beds | Pillowtop beds, individually decorated, individually furnished, desk
Super 8 by Wyndham Mt Pleasant
Super 8 by Wyndham Mt Pleasant
2.0 star property
Mount Pleasant
8.2 out of 10, Very Good, (849 reviews)
Escape to this tranquil hotel just a 3-minute drive from Mt. Pleasant Station. Wake up to complimentary breakfast, then explore nearby libraries. Enjoy free WiFi and parking while the attentive staff ensures a serene, clean retreat.
The price is $71
$80 total
includes taxes & fees
May 31 - Jun 1
Super 8 by Wyndham Mt Pleasant
Suite, 1 King Bed, Accessible, Non Smoking | In-room safe, desk, blackout drapes, iron/ironing board
Quality Inn & Suites Mount Pleasant
Quality Inn & Suites Mount Pleasant
2.5 star property
Mount Pleasant
8.2 out of 10, Very Good, (147 reviews)
Relax at this hotel with convenient train station access and complimentary amenities including daily buffet breakfast, WiFi and parking. The helpful staff receives consistent praise from travelers, while popular local attractions and libraries are just moments away.
The price is $70
$78 total
includes taxes & fees
May 31 - Jun 1
Quality Inn & Suites Mount Pleasant
Reception
The Sage Hotel
The Sage Hotel
2.0 star property
Muscatine
7.0 out of 10, Good, (70 reviews)
Unwind at this welcoming hotel where free breakfast, WiFi, and parking enhance your stay. Located near Muscatine Aquatic Center and Geneva Golf and Country Club, this comfortable retreat offers convenience for exploring the area's popular spots.
The price is $59
$66 total
includes taxes & fees
May 12 - May 13
The Sage Hotel
Suite, Multiple Beds, Non Smoking | Iron/ironing board, free WiFi, bed sheets
Comfort Inn Muscatine near Hwy 61
Comfort Inn Muscatine near Hwy 61
2.5 star property
Muscatine
7.8 out of 10, Good, (233 reviews)
Located near Highway 61, this welcoming hotel offers free WiFi, buffet breakfast, and parking. Take a refreshing swim in the indoor pool after exploring nearby Muscatine Aquatic Center and Geneva Golf and Country Club. Just 42 minutes from Quad City International Airport.
The price is $90
$101 total
includes taxes & fees
Jun 6 - Jun 7
Comfort Inn Muscatine near Hwy 61
Front of property
Evans Holly Grove Inn B&B
Evans Holly Grove Inn B&B
4.0 star property
Burlington
9.6 out of 10, Exceptional, (215 reviews)
The price is $140
$156 total
includes taxes & fees
May 24 - May 25
Evans Holly Grove Inn B&B
Interior
Holiday Inn Express Hotel & Suites Burlington by IHG
Holiday Inn Express Hotel & Suites Burlington by IHG
2.5 star property
Burlington
8.6 out of 10, Excellent, (496 reviews)
Just minutes from Catfish Bend Casino and FunCity, this Burlington hotel offers a refreshing indoor pool and complimentary morning meals. Enjoy free WiFi and parking after exploring nearby attractions or working out in the fitness center.
The price is $121
$139 total
includes taxes & fees
May 29 - May 30
Holiday Inn Express Hotel & Suites Burlington by IHG
Lobby
Fairfield Inn & Suites by Marriott Burlington
Fairfield Inn & Suites by Marriott Burlington
3.0 star property
Burlington
8.4 out of 10, Very Good, (307 reviews)
Wake to free breakfast at this business-friendly hotel before swimming in the indoor pool or heading to nearby Catfish Bend Casino. After exploring Burlington, return to your room, then grab a workout at the 24-hour fitness center.
The price is $127
$146 total
includes taxes & fees
May 28 - May 29
Fairfield Inn & Suites by Marriott Burlington
Reception
Best Western Muscatine / Pearl City Hotel
Best Western Muscatine / Pearl City Hotel
2.5 star property
Muscatine
8.6 out of 10, Excellent, (518 reviews)
This riverside hotel offers an oasis of tranquility despite being in a busy area. Just 5 minutes from the Mississippi River, enjoy free breakfast before exploring nearby Muscatine Aquatic Center. The indoor pool provides year-round relaxation.
The price is $90
$101 total
includes taxes & fees
May 13 - May 14
Best Western Muscatine / Pearl City Hotel
Reception
Hampton Inn Muscatine
Hampton Inn Muscatine
2.5 star property
Muscatine
8.4 out of 10, Very Good, (479 reviews)
This modern hotel offers free daily buffet breakfast, WiFi, and parking. After exploring nearby attractions, recharge in the 24-hour fitness center. Conveniently located in Muscatine with easy access to Quad City International Airport, just 37 minutes away.
The price is $114
$128 total
includes taxes & fees
May 21 - May 22
Hampton Inn Muscatine
Indoor pool
AmericInn by Wyndham Muscatine
AmericInn by Wyndham Muscatine
3.0 star property
Muscatine
7.6 out of 10, Good, (444 reviews)
Soak in the hot tub after exploring nearby Muscatine Aquatic Center at this welcoming hotel. Enjoy free breakfast, WiFi, and parking, plus an indoor pool for year-round swimming. Business amenities and proximity to the municipal golf course make this spot versatile.
The price is $84
$94 total
includes taxes & fees
May 18 - May 19
AmericInn by Wyndham Muscatine
Standard Room, 2 Double Beds | In-room safe, desk, blackout drapes, iron/ironing board
Super 8 by Wyndham Burlington
Super 8 by Wyndham Burlington
2.0 star property
Burlington
6.0 out of 10, (776 reviews)
Enjoy free WiFi and on-the-go breakfast at this business-friendly hotel just 5 minutes from Mississippi River. With FunCity and Catfish Bend Casino nearby, plus Burlington Station within 4 minutes, you'll find comfort and accessibility in one spot.
The price is $60
$67 total
includes taxes & fees
May 17 - May 18
Super 8 by Wyndham Burlington
Free buffet breakfast
Quality Inn Burlington near Hwy 34
Quality Inn Burlington near Hwy 34
2.5 star property
Burlington
7.4 out of 10, Good, (411 reviews)
This Quality Inn serves up a free breakfast buffet and offers convenient access to FunCity and Catfish Bend Casino. With complimentary WiFi and parking, plus attentive staff praised by fellow travelers, your Burlington entertainment getaway is hassle-free.
The price is $77
$87 total
includes taxes & fees
May 24 - May 25
Quality Inn Burlington near Hwy 34
48-inch flat-screen TV with cable channels, TV
The Merrill Hotel, Muscatine, a Tribute Portfolio Hotel
The Merrill Hotel, Muscatine, a Tribute Portfolio Hotel
4.0 star property
Muscatine
9.6 out of 10, Exceptional, (290 reviews)
Wake up to spectacular Mississippi River views at this Muscatine gem. Just steps from Riverside Park and the Muscatine Art Center, the hotel features an indoor pool, fitness center, and Maxwell's restaurant serving American cuisine throughout the day.
The price is $178
$199 total
includes taxes & fees
Jun 5 - Jun 6
The Merrill Hotel, Muscatine, a Tribute Portfolio Hotel
Terrace/patio
Hampton Inn & Suites Burlington
Hampton Inn & Suites Burlington
2.5 star property
Burlington
9.6 out of 10, Exceptional, (325 reviews)
The price is $130
$155 total
includes taxes & fees
May 21 - May 22
Hampton Inn & Suites Burlington
The Oxford Suite | Individually decorated, individually furnished, laptop workspace
Hall Building
Hall Building
2.0 star property
Aledo
10.0 out of 10, Exceptional, (2 reviews)
Experience charming accommodations at this historic Hall Building in Aledo. Enjoy convenient amenities including complimentary WiFi and parking, plus on-site laundry facilities. Just a 42-minute drive from Quad City International Airport.
The price is $282
$299 total
includes taxes & fees
May 12 - May 13
Hall Building
Casino
The Catfish Bend Inn & Spa
The Catfish Bend Inn & Spa
3.5 star property
Burlington
9.2 out of 10, Wonderful, (361 reviews)
Relaxation meets excitement at this hotel featuring 2 restaurants, 3 bars, and a full-service spa with massages. Near Catfish Bend Casino and FunCity, guests appreciate the helpful staff, outdoor pool, and free airport shuttle.
The price is $161
$186 total
includes taxes & fees
May 12 - May 13
The Catfish Bend Inn & Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Learn more about Wapello

The region around Wapello is home to attractions such as Mississippi River and Cairo Woods Wildlife Area.

See all hotels in Wapello
The Mississippi River near Hannibal, Missouri, USA

Check out reviews of Wapello hotels guests love

Super 8 by Wyndham Mt Pleasant

Super 8 by Wyndham Mt Pleasant

10/10 Excellent
"It was great and I will stay there again"
Shannon 1-night trip
Posted 14 hours ago
Super 8 by Wyndham Mt Pleasant

Frequently asked questions

Can I book a refundable accommodation in Wapello?
If you want the flexibility to change your plans to Wapello, most properties offer refundable* rates you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in Wapello be like during my trip?
July and August are typically the warmest months in Wapello when the average temp is 72°F. January and February are the coldest months when the average temperature is 30°F. June and May are the months with the most rain.
Why should I book my Wapello accommodation with Hotels.com?
There are lots of reasons to book your Wapello trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.