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Hotels in South San Francisco

October 2026
14
November 2026

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This weekend
Oct 16 - Oct 18
Next weekend
Oct 23 - Oct 25

Where to stay in South San Francisco?

A multi-level hotel atrium with outdoor seating areas, a pool, and a central lounge.
A large indoor swimming pool with clear water, surrounded by lounge chairs and potted plants.
A modern lobby with a reception desk, seating area, and decorative wall panels.
A modern hotel with a curved facade, multiple floors, and a well-lit entrance.

1. Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point
The East Side
$138
$163 total
includes taxes & fees
Nov 13 - Nov 14
Embassy Suites by Hilton San Francisco Airport Oyster Point
A bar area with a curved wooden counter, bar stools, and a glass display case filled with bottles.
A hotel room with a sofa set, a coffee table, a TV, and a patterned carpet.
Restaurant
A hotel lobby with blue seating, a coffee table, and a patterned rug.

2. Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel
South San Francisco
$107
$126 total
includes taxes & fees
Oct 31 - Nov 1
Best Western Plus Grosvenor Airport Hotel
A spacious, modern living area with a high ceiling, large windows, and a variety of seating options including sofas and chairs.
A modern interior with a long bench, decorative wall art, and a planter with large green plants.
A modern kitchen with a central island, bar stools, and a large window.
A coffee shop interior with a branded sign, shelves stocked with snacks, a coffee machine, and a refrigerated display.

3. DoubleTree by Hilton San Francisco South Airport Blvd

DoubleTree by Hilton San Francisco South Airport Blvd
South San Francisco
$130
$153 total
includes taxes & fees
Oct 25 - Oct 26
DoubleTree by Hilton San Francisco South Airport Blvd
A hotel lobby with a central reception desk, large columns, and hanging pendant lights.
A modern living room with a fireplace, a sofa, and a television.
A kitchen with a granite countertop, a built-in wine rack, and a flat-screen TV mounted on the wall.
A hotel entrance with a covered area, multiple floors, and a well-lit facade.

4. Hilton Garden Inn San Francisco Arpt North

Hilton Garden Inn San Francisco Arpt North
The East Side
$98
$115 total
includes taxes & fees
Nov 1 - Nov 2
Hilton Garden Inn San Francisco Arpt North
An outdoor patio with modern seating, a fire feature, and string lights.
A multi-story hotel with a modern design, featuring a prominent 'Home Suites' sign.
A hotel room with a wooden wall, a dining table with yellow chairs, a grey sofa, and a brown ottoman.
A modern hotel lobby with a seating area, a reception desk, and large windows offering a view of the parking area.

5. Home2 Suites by Hilton San Francisco Airport North

Home2 Suites by Hilton San Francisco Airport North
The East Side
$120
$140 total
includes taxes & fees
Nov 6 - Nov 7
Home2 Suites by Hilton San Francisco Airport North
A courtyard with outdoor seating, a glass table, and potted plants.
A hotel lobby with wooden furniture, a fireplace, and framed pictures on the walls.
A restaurant with wooden cabinets, red upholstered chairs, and a counter with coffee machines and food displays.
A hotel room with two beds, a wooden headboard, a bedside table with a lamp, and a window with curtains.

6. Comfort Inn and Suites San Francisco Airport North

Comfort Inn and Suites San Francisco Airport North
The East Side
$106
$124 total
includes taxes & fees
Oct 24 - Oct 25
Comfort Inn and Suites San Francisco Airport North
A modern living room with a stone wall, a flat-screen TV, leather sofas, and a dining area with natural light.
A modern lobby with a seating area, a flat-screen TV, a stone accent wall, and large windows.
A hotel room with a desk, a sofa, a TV, a window with a view of trees, and a lamp.
A hotel room with a sofa, a wooden table, a bed, a desk, a TV, and a large window with a view of a forest.

7. Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area

Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area
The East Side
$125
$146 total
includes taxes & fees
Nov 13 - Nov 14
Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area
Exterior
An outdoor patio area with seating and a building in the background.
A hotel room with two beds, a desk, a television, and a balcony with curtains.
A spacious lobby with a wooden floor, seating areas, a reception desk, and a bar area with shelves.

8. Sonesta Select San Francisco Airport Oyster Point Waterfront

Sonesta Select San Francisco Airport Oyster Point Waterfront
Oyster Point
$119
$140 total
includes taxes & fees
Oct 25 - Oct 26
Sonesta Select San Francisco Airport Oyster Point Waterfront
A modern building entrance with a covered walkway, large glass doors, and potted plants.
A hotel room with a double bed, a desk with a chair, a large mirror, a sink with a vanity, and a small bathroom area.
A hotel lobby with seating areas, a reception desk, and a bar.
A hotel hallway with an elevator, a red carpet, and a decorative wall piece.

9. Hampton Inn San Francisco Airport

Hampton Inn San Francisco Airport
The East Side
$114
$135 total
includes taxes & fees
Nov 8 - Nov 9
Hampton Inn San Francisco Airport
An outdoor dining area with tables and chairs, surrounded by glass walls and trees.
The exterior of the AC Hotel South San Francisco with a modern facade, large glass windows, and a well-lit entrance.
A modern bar area with a large TV screen, bar stools, and a view of a body of water.
A modern hotel room with a large bed, a sofa, a desk, and a view of the ocean.

10. AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
Oyster Point
$166
$196 total
includes taxes & fees
Nov 1 - Nov 2
AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
A La Quinta hotel with a modern facade, a covered entrance, and a parking lot.
A modern lobby with a wooden wall, seating area, and a flat-screen TV.
A modern living room with a grey sofa, a wooden coffee table, and a vibrant pink armchair. A kitchen area with a countertop and sink is visible in the background.
A modern kitchen with a central island, wooden cabinets, and stainless steel appliances.

11. La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Downtown South San Francisco
$132
$154 total
includes taxes & fees
Nov 12 - Nov 13
La Quinta Inn & Suites by Wyndham San Francisco Airport N
A hotel room with a bed, bedside lamps, a framed picture on the wall, and a vase with flowers.
A room with a flat-screen TV mounted above a fireplace, two benches in front, and a wooden floor.
A circular outdoor seating area with red Adirondack chairs and a central fire pit.
A multi-story hotel with a central entrance, a parking lot, and a signboard.

12. Hotel Focus SFO

Hotel Focus SFO
The East Side
$96
$113 total
includes taxes & fees
Nov 13 - Nov 14
Hotel Focus SFO
A modern hotel room with a sectional sofa, a wooden coffee table, a desk with a chair, a TV mounted on the wall, and a large window with sheer curtains.
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.
A teal armchair with a matching ottoman, a floor lamp, a small side table, and a curtain.
A bar area with wooden chairs, a black countertop, and various bottles and glasses.

13. Four Points by Sheraton Hotel & Suites San Francisco Airport

Four Points by Sheraton Hotel & Suites San Francisco Airport
South San Francisco
$103
$121 total
includes taxes & fees
Oct 25 - Oct 26
Four Points by Sheraton Hotel & Suites San Francisco Airport
A spacious lobby with a central seating area, a reception desk, and a second-floor balcony.
A hotel room with a bed, a TV, a desk, a kitchenette, and a seating area with a sofa and armchairs.
A Holiday Inn Express hotel with a well-lit entrance, a parking lot, and a clear sky.
A hotel room with a bed, a desk, a chair, a sofa, and a television.

14. Holiday Inn Express San Francisco-Airport North by IHG

Holiday Inn Express San Francisco-Airport North by IHG
South San Francisco
$110
$141 total
includes taxes & fees
Oct 17 - Oct 18
Holiday Inn Express San Francisco-Airport North by IHG
A modern hotel room with a large bed, a cityscape painting, a round mirror, a wooden nightstand, and a desk with a chair.
A multi-story hotel with a central courtyard, parking area, and a well-lit facade.
A reception desk with a logo for Days Inn by Wyndham, a white wall, and a ceiling with recessed lighting.
Breakfast area

15. Days Inn by Wyndham San Francisco S/Oyster Point Airport

Days Inn by Wyndham San Francisco S/Oyster Point Airport
Paradise Valley
$116
$144 total
includes taxes & fees
Oct 16 - Oct 17
Days Inn by Wyndham San Francisco S/Oyster Point Airport
A modern living room with a fireplace, a TV, a sofa, and a dining area with chairs.
A spacious dining area with high ceilings, large windows, and a variety of seating arrangements.
A multi-story hotel with a parking lot, surrounded by trees and a view of the ocean.
A hotel room with a sofa, a small round table, a bed, a TV, and a dining table with chairs.

16. Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
Oyster Point
$152
$179 total
includes taxes & fees
Nov 6 - Nov 7
Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
A hotel room with a bed, desk, chair, television, and a microwave.
A hotel with a prominent entrance, a covered walkway, and a parking area.
A breakfast bar with various food items and a sign that says "Healthy."
A hotel lobby with a reception desk, a coffee station, and seating areas.

17. Hotel Nova SFO

Hotel Nova SFO
South San Francisco
$140
$163 total
includes taxes & fees
Oct 16 - Oct 17
Hotel Nova SFO
A hotel room with a large window, a flat-screen TV, a glass coffee table, two wooden chairs, a patterned rug, and a potted plant.
A hotel room with two beds, each with a wooden headboard, white bedding, and a blue patterned throw. There is a nightstand with a lamp between the beds, and two framed artworks on the walls.
A Travelodge hotel with a modern design, featuring a prominent sign, a covered entrance, and a bench outside.
A conference room with rows of chairs facing a projection screen, carpeted floor, and large windows.

18. Travelodge by Wyndham San Francisco Airport North

Travelodge by Wyndham San Francisco Airport North
South San Francisco
$80
$94 total
includes taxes & fees
Nov 8 - Nov 9
Travelodge by Wyndham San Francisco Airport North
An indoor courtyard with a stone floor, a round table with chairs, and potted plants.
A hallway with potted plants, a bench, and a reception desk.
A reception area with a wooden desk, a vase of flowers, a map, and a view of the outside.
A courtyard with a flat roof, potted plants, and outdoor seating.

19. Airport Inn

Airport Inn
Downtown South San Francisco
$122
$143 total
includes taxes & fees
Nov 1 - Nov 2
Airport Inn
A stone facade with a sign for Larkspur Landing Home Suite Hotel, a lantern, and a flower bed.
A multi-story hotel with a central entrance, balconies, and a parking area.
An outdoor patio area with a stone wall, a wooden pergola with string lights, a grill, and metal chairs and tables.
A hotel breakfast area with a counter displaying bread, pastries, and a coffee station. There are two lamps on either side of the counter, and a menu sign is visible.

20. Larkspur Landing Extended Stay Suites South San Francisco

Larkspur Landing Extended Stay Suites South San Francisco
The East Side
$142
$166 total
includes taxes & fees
Nov 9 - Nov 10
Larkspur Landing Extended Stay Suites South San Francisco
View all properties

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A room with a TV, two blue chairs, a small table, and a painting of the ocean.
A hotel room with a bed, a nightstand, a desk, a mirror, and a bathroom visible through an open door.
A small round table with two black chairs, each with a metallic base.
A room with a red couch, a wooden table, a red armchair, a small round table with a plant, a dartboard, and a painting of a coastal scene.

Americana Inn

Americana Inn
South San Francisco
$200
per night
$232 total
includes taxes & fees
Americana Inn
A hotel room with a large window, a flat-screen TV, a glass coffee table, two wooden chairs, a patterned rug, and a potted plant.
A hotel room with two beds, each with a wooden headboard, white bedding, and a blue patterned throw. There is a nightstand with a lamp between the beds, and two framed artworks on the walls.
A Travelodge hotel with a modern design, featuring a prominent sign, a covered entrance, and a bench outside.
A conference room with rows of chairs facing a projection screen, carpeted floor, and large windows.

Travelodge by Wyndham San Francisco Airport North

Travelodge by Wyndham San Francisco Airport North
South San Francisco
$112 off
$308
per night
$356 total
includes taxes & fees
Travelodge by Wyndham San Francisco Airport North
A neatly made bed with white linens and a folded towel, a wooden headboard, and a window with blinds.
A residential building with a narrow front yard, a small porch, and a staircase leading to the entrance.
A dining area with a round table and four wooden chairs with floral cushions.
A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a coffee maker on the countertop.

Miller Apartments

Miller Apartments
Downtown South San Francisco
$6 off
$51
per night
$136 total
includes taxes & fees
Miller Apartments
A modern seating area with a bench and a round table, a concrete wall, and a view of greenery outside.
A modern interior with a red sofa, a round table, and a bench along a glass wall.
A modern living area with a large window, a red couch, a round table, and a wall-mounted clock.
A hotel reception area with a modern design, including a reception desk, a red seating area, and a wall with a large postage stamp.

Rodeway Inn South San Francisco Airport

Rodeway Inn South San Francisco Airport
South San Francisco
$205
per night
$238 total
includes taxes & fees
Rodeway Inn South San Francisco Airport
Exterior
An outdoor patio area with seating and a building in the background.
A hotel room with two beds, a desk, a television, and a balcony with curtains.
A spacious lobby with a wooden floor, seating areas, a reception desk, and a bar area with shelves.

Sonesta Select San Francisco Airport Oyster Point Waterfront

Sonesta Select San Francisco Airport Oyster Point Waterfront
Oyster Point
$394
per night
$458 total
includes taxes & fees
Sign in for extra savings
Sonesta Select San Francisco Airport Oyster Point Waterfront
A La Quinta hotel with a modern facade, a covered entrance, and a parking lot.
A modern lobby with a wooden wall, seating area, and a flat-screen TV.
A modern living room with a grey sofa, a wooden coffee table, and a vibrant pink armchair. A kitchen area with a countertop and sink is visible in the background.
A modern kitchen with a central island, wooden cabinets, and stainless steel appliances.

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Downtown South San Francisco
$439
per night
$507 total
includes taxes & fees
Sign in for extra savings
La Quinta Inn & Suites by Wyndham San Francisco Airport N
A hotel room with a bed, desk, chair, television, and a microwave.
A hotel with a prominent entrance, a covered walkway, and a parking area.
A breakfast bar with various food items and a sign that says "Healthy."
A hotel lobby with a reception desk, a coffee station, and seating areas.

Hotel Nova SFO

Hotel Nova SFO
South San Francisco
$440
per night
$507 total
includes taxes & fees
Sign in for extra savings
Hotel Nova SFO
A spacious lobby with a central seating area, a reception desk, and a second-floor balcony.
A hotel room with a bed, a TV, a desk, a kitchenette, and a seating area with a sofa and armchairs.
A Holiday Inn Express hotel with a well-lit entrance, a parking lot, and a clear sky.
A hotel room with a bed, a desk, a chair, a sofa, and a television.

Holiday Inn Express San Francisco-Airport North by IHG

Holiday Inn Express San Francisco-Airport North by IHG
South San Francisco
$53 off
$476
per night
$564 total
includes taxes & fees
Holiday Inn Express San Francisco-Airport North by IHG
A hotel room with a large bed, a desk, a chair, a coffee maker, and a TV.
A row of hotel rooms with blue shutters, potted plants, and a yellow tactile paving path.
A compact kitchenette with a microwave, coffee maker, and a small refrigerator.
A reception area with a counter, decorative vases, and a view of a parking lot with a white vehicle.

Deluxe Inn

Deluxe Inn
South San Francisco
$295
per night
$343 total
includes taxes & fees
Deluxe Inn
An outdoor dining area with tables and chairs, surrounded by glass walls and trees.
The exterior of the AC Hotel South San Francisco with a modern facade, large glass windows, and a well-lit entrance.
A modern bar area with a large TV screen, bar stools, and a view of a body of water.
A modern hotel room with a large bed, a sofa, a desk, and a view of the ocean.

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
Oyster Point
$839
per night
$975 total
includes taxes & fees
AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
An indoor courtyard with a stone floor, a round table with chairs, and potted plants.
A hallway with potted plants, a bench, and a reception desk.
A reception area with a wooden desk, a vase of flowers, a map, and a view of the outside.
A courtyard with a flat roof, potted plants, and outdoor seating.

Airport Inn

Airport Inn
Downtown South San Francisco
$443
per night
$511 total
includes taxes & fees
Sign in for extra savings
Airport Inn
A hotel room with a bed, a desk with a chair, a window with curtains, and a door leading to a bathroom.
A reception area with a glass door, a counter with magazines, and a view of the outside.
A covered walkway with stone walls and large windows.
A hotel entrance with a landscaped garden, a signboard, and a tiled roof.

Travelers Inn

Travelers Inn
South San Francisco
$494
per night
$569 total
includes taxes & fees
Sign in for extra savings
Travelers Inn
A stone facade with a sign for Larkspur Landing Home Suite Hotel, a lantern, and a flower bed.
A multi-story hotel with a central entrance, balconies, and a parking area.
An outdoor patio area with a stone wall, a wooden pergola with string lights, a grill, and metal chairs and tables.
A hotel breakfast area with a counter displaying bread, pastries, and a coffee station. There are two lamps on either side of the counter, and a menu sign is visible.

Larkspur Landing Extended Stay Suites South San Francisco

Larkspur Landing Extended Stay Suites South San Francisco
The East Side
Larkspur Landing Extended Stay Suites South San Francisco

Check out pet-friendly hotels in South San Francisco

A spacious, modern living area with a high ceiling, large windows, and a variety of seating options including sofas and chairs.
A modern interior with a long bench, decorative wall art, and a planter with large green plants.
A modern kitchen with a central island, bar stools, and a large window.
A coffee shop interior with a branded sign, shelves stocked with snacks, a coffee machine, and a refrigerated display.

DoubleTree by Hilton San Francisco South Airport Blvd

DoubleTree by Hilton San Francisco South Airport Blvd
South San Francisco
$130
$153 total
includes taxes & fees
Oct 25 - Oct 26
DoubleTree by Hilton San Francisco South Airport Blvd
A multi-level hotel atrium with outdoor seating areas, a pool, and a central lounge.
A large indoor swimming pool with clear water, surrounded by lounge chairs and potted plants.
A modern lobby with a reception desk, seating area, and decorative wall panels.
A modern hotel with a curved facade, multiple floors, and a well-lit entrance.

Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point
The East Side
$138
$163 total
includes taxes & fees
Nov 13 - Nov 14
Embassy Suites by Hilton San Francisco Airport Oyster Point
A hotel lobby with a central reception desk, large columns, and hanging pendant lights.
A modern living room with a fireplace, a sofa, and a television.
A kitchen with a granite countertop, a built-in wine rack, and a flat-screen TV mounted on the wall.
A hotel entrance with a covered area, multiple floors, and a well-lit facade.

Hilton Garden Inn San Francisco Arpt North

Hilton Garden Inn San Francisco Arpt North
The East Side
$98
$115 total
includes taxes & fees
Nov 1 - Nov 2
Hilton Garden Inn San Francisco Arpt North
An outdoor patio with modern seating, a fire feature, and string lights.
A multi-story hotel with a modern design, featuring a prominent 'Home Suites' sign.
A hotel room with a wooden wall, a dining table with yellow chairs, a grey sofa, and a brown ottoman.
A modern hotel lobby with a seating area, a reception desk, and large windows offering a view of the parking area.

Home2 Suites by Hilton San Francisco Airport North

Home2 Suites by Hilton San Francisco Airport North
The East Side
$120
$140 total
includes taxes & fees
Nov 6 - Nov 7
Home2 Suites by Hilton San Francisco Airport North
A La Quinta hotel with a modern facade, a covered entrance, and a parking lot.
A modern lobby with a wooden wall, seating area, and a flat-screen TV.
A modern living room with a grey sofa, a wooden coffee table, and a vibrant pink armchair. A kitchen area with a countertop and sink is visible in the background.
A modern kitchen with a central island, wooden cabinets, and stainless steel appliances.

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Downtown South San Francisco
$132
$154 total
includes taxes & fees
Nov 12 - Nov 13
La Quinta Inn & Suites by Wyndham San Francisco Airport N
A modern living room with a stone wall, a flat-screen TV, leather sofas, and a dining area with natural light.
A modern lobby with a seating area, a flat-screen TV, a stone accent wall, and large windows.
A hotel room with a desk, a sofa, a TV, a window with a view of trees, and a lamp.
A hotel room with a sofa, a wooden table, a bed, a desk, a TV, and a large window with a view of a forest.

Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area

Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area
The East Side
$125
$146 total
includes taxes & fees
Nov 13 - Nov 14
Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area
Exterior
An outdoor patio area with seating and a building in the background.
A hotel room with two beds, a desk, a television, and a balcony with curtains.
A spacious lobby with a wooden floor, seating areas, a reception desk, and a bar area with shelves.

Sonesta Select San Francisco Airport Oyster Point Waterfront

Sonesta Select San Francisco Airport Oyster Point Waterfront
Oyster Point
$119
$140 total
includes taxes & fees
Oct 25 - Oct 26
Sonesta Select San Francisco Airport Oyster Point Waterfront
An outdoor dining area with tables and chairs, surrounded by glass walls and trees.
The exterior of the AC Hotel South San Francisco with a modern facade, large glass windows, and a well-lit entrance.
A modern bar area with a large TV screen, bar stools, and a view of a body of water.
A modern hotel room with a large bed, a sofa, a desk, and a view of the ocean.

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
Oyster Point
$166
$196 total
includes taxes & fees
Nov 1 - Nov 2
AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
A modern building entrance with a covered walkway, large glass doors, and potted plants.
A hotel room with a double bed, a desk with a chair, a large mirror, a sink with a vanity, and a small bathroom area.
A hotel lobby with seating areas, a reception desk, and a bar.
A hotel hallway with an elevator, a red carpet, and a decorative wall piece.

Hampton Inn San Francisco Airport

Hampton Inn San Francisco Airport
The East Side
$114
$135 total
includes taxes & fees
Nov 8 - Nov 9
Hampton Inn San Francisco Airport
A hotel room with a bed, bedside lamps, a framed picture on the wall, and a vase with flowers.
A room with a flat-screen TV mounted above a fireplace, two benches in front, and a wooden floor.
A circular outdoor seating area with red Adirondack chairs and a central fire pit.
A multi-story hotel with a central entrance, a parking lot, and a signboard.

Hotel Focus SFO

Hotel Focus SFO
The East Side
$96
$113 total
includes taxes & fees
Nov 13 - Nov 14
Hotel Focus SFO
View all properties

You may also like hotels with pools in South San Francisco

A multi-level hotel atrium with outdoor seating areas, a pool, and a central lounge.
A large indoor swimming pool with clear water, surrounded by lounge chairs and potted plants.
A modern lobby with a reception desk, seating area, and decorative wall panels.
A modern hotel with a curved facade, multiple floors, and a well-lit entrance.

Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point
The East Side
$138
$163 total
includes taxes & fees
Nov 13 - Nov 14
Embassy Suites by Hilton San Francisco Airport Oyster Point
An outdoor dining area with tables and chairs, surrounded by glass walls and trees.
The exterior of the AC Hotel South San Francisco with a modern facade, large glass windows, and a well-lit entrance.
A modern bar area with a large TV screen, bar stools, and a view of a body of water.
A modern hotel room with a large bed, a sofa, a desk, and a view of the ocean.

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
Oyster Point
$166
$196 total
includes taxes & fees
Nov 1 - Nov 2
AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
A La Quinta hotel with a modern facade, a covered entrance, and a parking lot.
A modern lobby with a wooden wall, seating area, and a flat-screen TV.
A modern living room with a grey sofa, a wooden coffee table, and a vibrant pink armchair. A kitchen area with a countertop and sink is visible in the background.
A modern kitchen with a central island, wooden cabinets, and stainless steel appliances.

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Downtown South San Francisco
$132
$154 total
includes taxes & fees
Nov 12 - Nov 13
La Quinta Inn & Suites by Wyndham San Francisco Airport N
A modern living room with a fireplace, a TV, a sofa, and a dining area with chairs.
A spacious dining area with high ceilings, large windows, and a variety of seating arrangements.
A multi-story hotel with a parking lot, surrounded by trees and a view of the ocean.
A hotel room with a sofa, a small round table, a bed, a TV, and a dining table with chairs.

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
Oyster Point
$152
$179 total
includes taxes & fees
Nov 6 - Nov 7
Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
A hotel room with a large window, a flat-screen TV, a glass coffee table, two wooden chairs, a patterned rug, and a potted plant.
A hotel room with two beds, each with a wooden headboard, white bedding, and a blue patterned throw. There is a nightstand with a lamp between the beds, and two framed artworks on the walls.
A Travelodge hotel with a modern design, featuring a prominent sign, a covered entrance, and a bench outside.
A conference room with rows of chairs facing a projection screen, carpeted floor, and large windows.

Travelodge by Wyndham San Francisco Airport North

Travelodge by Wyndham San Francisco Airport North
South San Francisco
$80
$94 total
includes taxes & fees
Nov 8 - Nov 9
Travelodge by Wyndham San Francisco Airport North
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Go beyond your typical stay in South San Francisco

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Pet friendly
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Pool
Pool
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Hot tub
Hot tub
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Family friendly
Family friendly
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Spa
Spa
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Apart hotel
Apart hotel
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Apart­ment
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Cottage
Cottage
Our prices for hotels in South San Francisco are cheapest in January

Price trends for hotels in South San Francisco

Pricing is based on two traveler single night rates
View properties in October

October

High 19°C / low 14°C. Sunny most days.
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Monthly weather averages (˚C)

Top neighborhoods in South San Francisco

A panoramic view of San Francisco's South Peninsula, highlighting the city's dense urban areas, rolling hills, and the iconic Golden Gate Bridge in the distance.
An aerial view of a city with a large stadium, several schools, and a dense residential area.
An aerial view of a coastal city with a dense urban area, a large port, and a mountainous backdrop.

Downtown South San Francisco

Downtown South San Francisco buzzes with a blend of biotech innovation and cultural diversity. Corporate towers and colorful murals tell the story of this unique business hub. You'll find authentic taquerias, dim sum houses, and Filipino eateries nestled between modern office campuses along Grand Avenue. The neighborhood comes alive during weekdays when professionals fill its plazas and restaurants. Getting around is a breeze with nearby BART and Caltrain stations connecting you to San Francisco proper and beyond. Business hotels cater mostly to corporate travelers with practical amenities. The area quiets down after work hours, offering a genuine glimpse into Bay Area life away from tourist crowds.

A wooden bridge over a river, surrounded by autumn-colored vegetation and a distant mountain.
A nighttime view of the Golden Gate Bridge with its distinctive orange color and suspension cables.
A modern building complex by a calm river with sparse vegetation.

Oyster Point

Oyster Point balances sleek biotech campuses with stunning San Francisco Bay views. The waterfront promenade offers perfect spots for watching waves crash against the shore or catching a beautiful sunset. Modern plazas feature public art installations while walking paths showcase both cutting-edge architecture and natural bay ecosystems. Business travelers appreciate the corporate hotels with meeting facilities and convenient access to office buildings. Dining options cater primarily to weekday lunch crowds, with most establishments closing early evening. The area is best explored by car, though waterfront paths provide scenic strolling opportunities away from the corporate hustle.

The Golden Gate Bridge with its distinctive red towers and cables, spanning across the San Francisco Bay.
A large, modern bridge with a unique design against a clear blue sky.
Photo by Tonette Pineda✈⛵🚌🚉🚃🚅🚀

The East Side

The East Side delivers authentic local life away from San Francisco's tourist traps. Catch Bay views from San Bruno Point Park or explore diverse family-owned restaurants along Grand Avenue serving up killer tacos and pho. This residential neighborhood mixes Hispanic and Asian influences that shine through local markets and casual eateries. Budget travelers appreciate the affordable motels and extended-stay options that cost way less than downtown San Francisco. Buses connect to BART and Caltrain, though having wheels helps. Most spots close early, so plan your food adventures accordingly.

A mountainous landscape with rolling hills, dense forests, and a distant view of hills.

Paradise Valley

Paradise Valley offers a peaceful retreat from San Francisco's bustle while keeping you close to the action. This quiet residential neighborhood in South San Francisco balances suburban calm with convenient access to nearby attractions. Take a stroll through San Bruno Point Park or venture to local spots like K1 Speed for some indoor racing fun. Budget-friendly accommodations make Paradise Valley an appealing base for Bay Area exploration. The neighborhood's proximity to San Francisco International Airport and major highways ensures easy connections throughout the region. With ample street parking and minimal crowds, you'll appreciate this low-key alternative to the city's more hectic districts.

The Golden Gate Bridge spanning the Golden Gate Strait, with a city skyline in the background.

Serra Highlands

Serra Highlands offers a peaceful retreat from the Bay Area buzz with its hillside streets and family-friendly vibe. While there aren't tourist attractions within the neighborhood itself, you'll enjoy stunning panoramic views, quiet walking paths, and easy access to nearby highlights like Serramonte Center. Morning fog rolling over the hills creates a mystical atmosphere worth waking up for. Getting around requires a car or rideshare, as public transit is limited in this residential area. Accommodations consist mainly of vacation rental homes with suburban comforts like driveways and yards. For dining and shopping, you'll need to venture to surrounding commercial areas, making Serra Highlands perfect for travelers seeking authentic local living.

Top landmarks in South San Francisco

San Bruno Point Park

7.8/10 (451 reviews)
If you like quiet time surrounded by flowers and greenery, hang out at San Bruno Point Park in The East Side. Our travelers also like this walkable area for its restaurants. Want to stretch your legs some more? Head to Bayfront Park and John McLaren Park, both nearby.
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South San Francisco Convention Center

7.8/10 (668 reviews)
South San Francisco Convention Center is worth a visit, located 0.5 mi (0.8 km) from central South San Francisco. Hotels.com travelers also say the area is artsy and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander.
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San Francisco Baking Institute

7.6/10 (423 reviews)
If you'd like to get a taste of South San Francisco student life, check out San Francisco Baking Institute in The East Side. Let yourself be amazed at the art galleries in the area— your cultural tour starts here. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. South San Francisco has other landmarks you might want to visit such as Golden Gate Bridge.
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South San Francisco Hillside Sign

If you're planning a bit of sightseeing head to South San Francisco Hillside Sign— just one of the monuments in Paradise Valley. South San Francisco has other landmarks you might want to visit such as Golden Gate Bridge.
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See's Candies

8.0/10 (474 reviews)
See's Candies is 1.2 mi (2 km) from central South San Francisco, why not stop by during your stay. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. If you have fun at See's Candies, you'll love K1 Speed San Francisco, located nearby.
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K1 Speed San Francisco

7.6/10 (330 reviews)
K1 Speed San Francisco is 1.1 mi (1.7 km) from central South San Francisco, why not stop by during your stay. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. If you have fun at K1 Speed San Francisco, you'll love See's Candies, located nearby.
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Sign Hill Park

If you like quiet time surrounded by flowers and greenery, then make a stop at Sign Hill Park located 8.6 mi (13.8 km) from the center of San Francisco. Want to stretch your legs some more? Head to Bayfront Park and San Bruno Point Park, both nearby.
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Learn more about South San Francisco

Look beyond the iconic 'South San Francisco The Industrial City' sign crowning Sign Hill Park for a city with its own distinct identity. Grand Avenue serves up a global feast of family-run eateries where locals debate the merits of each dumpling house. San Bruno Mountain offers hiking trails with sweeping Bay views that explain why residents tolerate the fog. See's Candies factory tours satisfy sweet tooths, while K1 Speed delivers indoor racing thrills. The Convention Center hosts events that draw visitors who are surprised to discover this isn't simply San Francisco's southern neighborhood. Despite tripling in population since World War II, 'South City' maintains its working-class roots while embracing its role as a Peninsula destination in its own right.

See all hotels in South San Francisco
A coastal cityscape with a prominent bridge, clear blue waters, and a marina.

Check out reviews of South San Francisco hotels guests love

An outdoor dining area with tables and chairs, surrounded by glass walls and trees.
The exterior of the AC Hotel South San Francisco with a modern facade, large glass windows, and a well-lit entrance.
A modern bar area with a large TV screen, bar stools, and a view of a body of water.
A modern hotel room with a large bed, a sofa, a desk, and a view of the ocean.

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
Oyster Point

10/10 Exceptional

United States
Frances
AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
An outdoor patio with modern seating, a fire feature, and string lights.
A multi-story hotel with a modern design, featuring a prominent 'Home Suites' sign.
A hotel room with a wooden wall, a dining table with yellow chairs, a grey sofa, and a brown ottoman.
A modern hotel lobby with a seating area, a reception desk, and large windows offering a view of the parking area.

Home2 Suites by Hilton San Francisco Airport North

Home2 Suites by Hilton San Francisco Airport North
The East Side

10/10 Exceptional

United States
Anavel
Home2 Suites by Hilton San Francisco Airport North
A modern living room with a stone wall, a flat-screen TV, leather sofas, and a dining area with natural light.
A modern lobby with a seating area, a flat-screen TV, a stone accent wall, and large windows.
A hotel room with a desk, a sofa, a TV, a window with a view of trees, and a lamp.
A hotel room with a sofa, a wooden table, a bed, a desk, a TV, and a large window with a view of a forest.

Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area

Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area
The East Side

10/10 Exceptional

United States
Jacqueline
Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area
An indoor courtyard with a stone floor, a round table with chairs, and potted plants.
A hallway with potted plants, a bench, and a reception desk.
A reception area with a wooden desk, a vase of flowers, a map, and a view of the outside.
A courtyard with a flat roof, potted plants, and outdoor seating.

Airport Inn

Airport Inn
Downtown South San Francisco

10/10 Exceptional

United States
Vincent
Airport Inn
A multi-level hotel atrium with outdoor seating areas, a pool, and a central lounge.
A large indoor swimming pool with clear water, surrounded by lounge chairs and potted plants.
A modern lobby with a reception desk, seating area, and decorative wall panels.
A modern hotel with a curved facade, multiple floors, and a well-lit entrance.

Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point
The East Side

10/10 Exceptional

United States
Brianna
Embassy Suites by Hilton San Francisco Airport Oyster Point
Exterior
An outdoor patio area with seating and a building in the background.
A hotel room with two beds, a desk, a television, and a balcony with curtains.
A spacious lobby with a wooden floor, seating areas, a reception desk, and a bar area with shelves.

Sonesta Select San Francisco Airport Oyster Point Waterfront

Sonesta Select San Francisco Airport Oyster Point Waterfront
Oyster Point

10/10 Exceptional

United States
Paula
Sonesta Select San Francisco Airport Oyster Point Waterfront
A hotel room with a bed, desk, chair, television, and a microwave.
A hotel with a prominent entrance, a covered walkway, and a parking area.
A breakfast bar with various food items and a sign that says "Healthy."
A hotel lobby with a reception desk, a coffee station, and seating areas.

Hotel Nova SFO

Hotel Nova SFO
South San Francisco

10/10 Exceptional

United States
Genevieve
Hotel Nova SFO
A modern building entrance with a covered walkway, large glass doors, and potted plants.
A hotel room with a double bed, a desk with a chair, a large mirror, a sink with a vanity, and a small bathroom area.
A hotel lobby with seating areas, a reception desk, and a bar.
A hotel hallway with an elevator, a red carpet, and a decorative wall piece.

Hampton Inn San Francisco Airport

Hampton Inn San Francisco Airport
The East Side

10/10 Exceptional

United States
Sandra
Hampton Inn San Francisco Airport
A hotel lobby with a central reception desk, large columns, and hanging pendant lights.
A modern living room with a fireplace, a sofa, and a television.
A kitchen with a granite countertop, a built-in wine rack, and a flat-screen TV mounted on the wall.
A hotel entrance with a covered area, multiple floors, and a well-lit facade.

Hilton Garden Inn San Francisco Arpt North

Hilton Garden Inn San Francisco Arpt North
The East Side

10/10 Exceptional

United States
Kathleen
Hilton Garden Inn San Francisco Arpt North
A bar area with a curved wooden counter, bar stools, and a glass display case filled with bottles.
A hotel room with a sofa set, a coffee table, a TV, and a patterned carpet.
Restaurant
A hotel lobby with blue seating, a coffee table, and a patterned rug.

Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel
South San Francisco

10/10 Exceptional

United States
Leslie
Best Western Plus Grosvenor Airport Hotel
A spacious, modern living area with a high ceiling, large windows, and a variety of seating options including sofas and chairs.
A modern interior with a long bench, decorative wall art, and a planter with large green plants.
A modern kitchen with a central island, bar stools, and a large window.
A coffee shop interior with a branded sign, shelves stocked with snacks, a coffee machine, and a refrigerated display.

DoubleTree by Hilton San Francisco South Airport Blvd

DoubleTree by Hilton San Francisco South Airport Blvd
South San Francisco

10/10 Exceptional

United States
Dionne
DoubleTree by Hilton San Francisco South Airport Blvd
A modern hotel room with a large bed, a cityscape painting, a round mirror, a wooden nightstand, and a desk with a chair.
A multi-story hotel with a central courtyard, parking area, and a well-lit facade.
A reception desk with a logo for Days Inn by Wyndham, a white wall, and a ceiling with recessed lighting.
Breakfast area

Days Inn by Wyndham San Francisco S/Oyster Point Airport

Days Inn by Wyndham San Francisco S/Oyster Point Airport
Paradise Valley

10/10 Exceptional

United States
Katy
Days Inn by Wyndham San Francisco S/Oyster Point Airport
A modern living room with a fireplace, a TV, a sofa, and a dining area with chairs.
A spacious dining area with high ceilings, large windows, and a variety of seating arrangements.
A multi-story hotel with a parking lot, surrounded by trees and a view of the ocean.
A hotel room with a sofa, a small round table, a bed, a TV, and a dining table with chairs.

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
Oyster Point

10/10 Exceptional

United States
Richard
Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
A La Quinta hotel with a modern facade, a covered entrance, and a parking lot.
A modern lobby with a wooden wall, seating area, and a flat-screen TV.
A modern living room with a grey sofa, a wooden coffee table, and a vibrant pink armchair. A kitchen area with a countertop and sink is visible in the background.
A modern kitchen with a central island, wooden cabinets, and stainless steel appliances.

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Downtown South San Francisco

10/10 Exceptional

United States
Michelle
La Quinta Inn & Suites by Wyndham San Francisco Airport N
A spacious lobby with a central seating area, a reception desk, and a second-floor balcony.
A hotel room with a bed, a TV, a desk, a kitchenette, and a seating area with a sofa and armchairs.
A Holiday Inn Express hotel with a well-lit entrance, a parking lot, and a clear sky.
A hotel room with a bed, a desk, a chair, a sofa, and a television.

Holiday Inn Express San Francisco-Airport North by IHG

Holiday Inn Express San Francisco-Airport North by IHG
South San Francisco

10/10 Exceptional

United States
Ronnie
Holiday Inn Express San Francisco-Airport North by IHG
A courtyard with outdoor seating, a glass table, and potted plants.
A hotel lobby with wooden furniture, a fireplace, and framed pictures on the walls.
A restaurant with wooden cabinets, red upholstered chairs, and a counter with coffee machines and food displays.
A hotel room with two beds, a wooden headboard, a bedside table with a lamp, and a window with curtains.

Comfort Inn and Suites San Francisco Airport North

Comfort Inn and Suites San Francisco Airport North
The East Side

10/10 Exceptional

United States
Randall
Comfort Inn and Suites San Francisco Airport North
A room with a TV, two blue chairs, a small table, and a painting of the ocean.
A hotel room with a bed, a nightstand, a desk, a mirror, and a bathroom visible through an open door.
A small round table with two black chairs, each with a metallic base.
A room with a red couch, a wooden table, a red armchair, a small round table with a plant, a dartboard, and a painting of a coastal scene.

Americana Inn

Americana Inn
South San Francisco

10/10 Exceptional

United States
Anonymous traveler
Americana Inn
A modern hotel room with a sectional sofa, a wooden coffee table, a desk with a chair, a TV mounted on the wall, and a large window with sheer curtains.
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.
A teal armchair with a matching ottoman, a floor lamp, a small side table, and a curtain.
A bar area with wooden chairs, a black countertop, and various bottles and glasses.

Four Points by Sheraton Hotel & Suites San Francisco Airport

Four Points by Sheraton Hotel & Suites San Francisco Airport
South San Francisco

10/10 Exceptional

United States
Anonymous traveler
Four Points by Sheraton Hotel & Suites San Francisco Airport
A hotel room with a bed, bedside lamps, a framed picture on the wall, and a vase with flowers.
A room with a flat-screen TV mounted above a fireplace, two benches in front, and a wooden floor.
A circular outdoor seating area with red Adirondack chairs and a central fire pit.
A multi-story hotel with a central entrance, a parking lot, and a signboard.

Hotel Focus SFO

Hotel Focus SFO
The East Side

10/10 Exceptional

United States
Marsha
Hotel Focus SFO

Frequently Asked Questions

What accommodations do travelers like in South San Francisco?

Guests like Travelodge by Wyndham San Francisco Airport North, Park Pointe Hotel and DoubleTree by Hilton San Francisco South Airport Blvd.

Can I book refundable accommodations in South San Francisco?

If you need the flexibility to change your travel plans to South San Francisco, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow down the results.

Where can I stay in South San Francisco if I want a vacation rental instead of a hotel?

If you're looking for a good alternative to a hotel, review our selection of 27 vacation homes. In addition, you can choose from 13 apartments.

What will the weather in South San Francisco be like during my visit?

The warmest months in South San Francisco are usually September and August with an average temp of 62°F. February and January are the chilliest months when the average temp is 53°F. The rainiest months are December and January.

Why should I book my South San Francisco accommodation with Hotels.com?

There are lots of reasons to book your South San Francisco trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.