Hotels in South San Francisco

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight
Sep 3 - Sep 4
Tomorrow
Sep 4 - Sep 5
This weekend
Sep 4 - Sep 6
Next weekend
Sep 11 - Sep 13

Top 5 hotels in South San Francisco at a glance

  1. DoubleTree by Hilton San Francisco South Airport Blvd — 4-star hotel in South San Francisco. Guest rating: 8.4/10 — Very Good.
  2. Sonesta Select San Francisco Airport Oyster Point Waterfront — 3-star hotel in Oyster Point. Guest rating: 8.8/10 — Excellent.
  3. Hilton Garden Inn San Francisco Arpt North — 3-star hotel in The East Side. Guest rating: 8.6/10 — Excellent.
  4. Hotel Nova SFO — 2.5-star hotel in South San Francisco. Guest rating: 8.8/10 — Excellent.
  5. Best Western Plus Grosvenor Airport Hotel — 3-star hotel in South San Francisco. Guest rating: 8.4/10 — Very Good.

Where to stay in South San Francisco?

DoubleTree by Hilton San Francisco South Airport Blvd

DoubleTree by Hilton San Francisco South Airport Blvd
South San Francisco
$130
$153 total
includes taxes & fees
Sep 11 - Sep 12
DoubleTree by Hilton San Francisco South Airport Blvd

Sonesta Select San Francisco Airport Oyster Point Waterfront

Sonesta Select San Francisco Airport Oyster Point Waterfront
Oyster Point
$122
$144 total
includes taxes & fees
Sep 20 - Sep 21
Sonesta Select San Francisco Airport Oyster Point Waterfront

Hilton Garden Inn San Francisco Arpt North

Hilton Garden Inn San Francisco Arpt North
The East Side
$109
$128 total
includes taxes & fees
Sep 20 - Sep 21
Hilton Garden Inn San Francisco Arpt North

Hotel Nova SFO

Hotel Nova SFO
South San Francisco
$120
$140 total
includes taxes & fees
Sep 4 - Sep 5
Hotel Nova SFO

Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel
South San Francisco
$113
$133 total
includes taxes & fees
Sep 6 - Sep 7
Best Western Plus Grosvenor Airport Hotel

Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point
The East Side
$147
$172 total
includes taxes & fees
Sep 11 - Sep 12
Embassy Suites by Hilton San Francisco Airport Oyster Point

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Downtown South San Francisco
$118
$138 total
includes taxes & fees
Sep 10 - Sep 11
La Quinta Inn & Suites by Wyndham San Francisco Airport N

Home2 Suites by Hilton San Francisco Airport North

Home2 Suites by Hilton San Francisco Airport North
The East Side
$144
$168 total
includes taxes & fees
Sep 6 - Sep 7
Home2 Suites by Hilton San Francisco Airport North

Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area

Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area
The East Side
$138
$161 total
includes taxes & fees
Sep 6 - Sep 7
Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area

Hampton Inn San Francisco Airport

Hampton Inn San Francisco Airport
The East Side
$114
$135 total
includes taxes & fees
Sep 20 - Sep 21
Hampton Inn San Francisco Airport

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
Oyster Point
$145
$171 total
includes taxes & fees
Sep 7 - Sep 8
Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

Larkspur Landing Extended Stay Suites South San Francisco

Larkspur Landing Extended Stay Suites South San Francisco
The East Side
$123
$145 total
includes taxes & fees
Sep 5 - Sep 6
Larkspur Landing Extended Stay Suites South San Francisco

Travelodge by Wyndham San Francisco Airport North

Travelodge by Wyndham San Francisco Airport North
South San Francisco
$77
$92 total
includes taxes & fees
Sep 8 - Sep 9
Travelodge by Wyndham San Francisco Airport North

Four Points by Sheraton Hotel & Suites San Francisco Airport

Four Points by Sheraton Hotel & Suites San Francisco Airport
South San Francisco
$103
$121 total
includes taxes & fees
Sep 20 - Sep 21
Four Points by Sheraton Hotel & Suites San Francisco Airport

Holiday Inn Express San Francisco-Airport North by IHG

Holiday Inn Express San Francisco-Airport North by IHG
South San Francisco
$104
$134 total
includes taxes & fees
Sep 6 - Sep 7
Holiday Inn Express San Francisco-Airport North by IHG

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
Oyster Point
$179
$212 total
includes taxes & fees
Sep 11 - Sep 12
AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

Comfort Inn and Suites San Francisco Airport North

Comfort Inn and Suites San Francisco Airport North
The East Side
$106
$125 total
includes taxes & fees
Oct 4 - Oct 5
Comfort Inn and Suites San Francisco Airport North

Hotel Focus SFO

Hotel Focus SFO
The East Side
$100
$118 total
includes taxes & fees
Sep 5 - Sep 6
Hotel Focus SFO

Inn By The SFO

Inn By The SFO
Downtown South San Francisco
$84
$99 total
includes taxes & fees
Sep 4 - Sep 5
Inn By The SFO

Airport Inn

Airport Inn
Downtown South San Francisco
$122
$143 total
includes taxes & fees
Sep 4 - Sep 5
Airport Inn
View all properties

Check out pet-friendly hotels in South San Francisco

DoubleTree by Hilton San Francisco South Airport Blvd

DoubleTree by Hilton San Francisco South Airport Blvd
South San Francisco
$130
$153 total
includes taxes & fees
Sep 11 - Sep 12
DoubleTree by Hilton San Francisco South Airport Blvd

Sonesta Select San Francisco Airport Oyster Point Waterfront

Sonesta Select San Francisco Airport Oyster Point Waterfront
Oyster Point
$122
$144 total
includes taxes & fees
Sep 20 - Sep 21
Sonesta Select San Francisco Airport Oyster Point Waterfront

Hilton Garden Inn San Francisco Arpt North

Hilton Garden Inn San Francisco Arpt North
The East Side
$109
$128 total
includes taxes & fees
Sep 20 - Sep 21
Hilton Garden Inn San Francisco Arpt North

Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point
The East Side
$147
$172 total
includes taxes & fees
Sep 11 - Sep 12
Embassy Suites by Hilton San Francisco Airport Oyster Point

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Downtown South San Francisco
$118
$138 total
includes taxes & fees
Sep 10 - Sep 11
La Quinta Inn & Suites by Wyndham San Francisco Airport N

Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area

Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area
The East Side
$138
$161 total
includes taxes & fees
Sep 6 - Sep 7
Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area

Home2 Suites by Hilton San Francisco Airport North

Home2 Suites by Hilton San Francisco Airport North
The East Side
$144
$168 total
includes taxes & fees
Sep 6 - Sep 7
Home2 Suites by Hilton San Francisco Airport North

Hampton Inn San Francisco Airport

Hampton Inn San Francisco Airport
The East Side
$114
$135 total
includes taxes & fees
Sep 20 - Sep 21
Hampton Inn San Francisco Airport

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
Oyster Point
$145
$171 total
includes taxes & fees
Sep 7 - Sep 8
Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

Hotel Focus SFO

Hotel Focus SFO
The East Side
$100
$118 total
includes taxes & fees
Sep 5 - Sep 6
Hotel Focus SFO
View all properties

You may also like hotels with pools in South San Francisco

Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point
The East Side
$147
$172 total
includes taxes & fees
Sep 11 - Sep 12
Embassy Suites by Hilton San Francisco Airport Oyster Point

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
Oyster Point
$145
$171 total
includes taxes & fees
Sep 7 - Sep 8
Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Downtown South San Francisco
$118
$138 total
includes taxes & fees
Sep 10 - Sep 11
La Quinta Inn & Suites by Wyndham San Francisco Airport N

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
Oyster Point
$179
$212 total
includes taxes & fees
Sep 11 - Sep 12
AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

Travelodge by Wyndham San Francisco Airport North

Travelodge by Wyndham San Francisco Airport North
South San Francisco
$77
$92 total
includes taxes & fees
Sep 8 - Sep 9
Travelodge by Wyndham San Francisco Airport North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Our prices for hotels in South San Francisco are cheapest in January
Price trends for hotels in South San Francisco
Pricing is based on two traveler single night rates
View properties in September
Typical weather for South San Francisco
September
High 20°C / low 15°C. Sunny most days.
View properties in September
20°
15°
19°
14°
17°
11°
14°
14°
15°
15°
16°
10°
17°
11°
19°
13°
19°
13°
20°
14°
Monthly weather averages (˚C)

Top neighborhoods in South San Francisco

Downtown South San Francisco

Downtown South San Francisco buzzes with a blend of biotech innovation and cultural diversity. Corporate towers and colorful murals tell the story of this unique business hub. You'll find authentic taquerias, dim sum houses, and Filipino eateries nestled between modern office campuses along Grand Avenue. The neighborhood comes alive during weekdays when professionals fill its plazas and restaurants. Getting around is a breeze with nearby BART and Caltrain stations connecting you to San Francisco proper and beyond. Business hotels cater mostly to corporate travelers with practical amenities. The area quiets down after work hours, offering a genuine glimpse into Bay Area life away from tourist crowds.

Oyster Point

Oyster Point balances sleek biotech campuses with stunning San Francisco Bay views. The waterfront promenade offers perfect spots for watching waves crash against the shore or catching a beautiful sunset. Modern plazas feature public art installations while walking paths showcase both cutting-edge architecture and natural bay ecosystems. Business travelers appreciate the corporate hotels with meeting facilities and convenient access to office buildings. Dining options cater primarily to weekday lunch crowds, with most establishments closing early evening. The area is best explored by car, though waterfront paths provide scenic strolling opportunities away from the corporate hustle.

The East Side

The East Side delivers authentic local life away from San Francisco's tourist traps. Catch Bay views from San Bruno Point Park or explore diverse family-owned restaurants along Grand Avenue serving up killer tacos and pho. This residential neighborhood mixes Hispanic and Asian influences that shine through local markets and casual eateries. Budget travelers appreciate the affordable motels and extended-stay options that cost way less than downtown San Francisco. Buses connect to BART and Caltrain, though having wheels helps. Most spots close early, so plan your food adventures accordingly.

Paradise Valley

Paradise Valley offers a peaceful retreat from San Francisco's bustle while keeping you close to the action. This quiet residential neighborhood in South San Francisco balances suburban calm with convenient access to nearby attractions. Take a stroll through San Bruno Point Park or venture to local spots like K1 Speed for some indoor racing fun. Budget-friendly accommodations make Paradise Valley an appealing base for Bay Area exploration. The neighborhood's proximity to San Francisco International Airport and major highways ensures easy connections throughout the region. With ample street parking and minimal crowds, you'll appreciate this low-key alternative to the city's more hectic districts.

Top landmarks in South San Francisco

San Bruno Point Park

7.8/10 (451 reviews)
If you like quiet time surrounded by flowers and greenery, hang out at San Bruno Point Park in The East Side. Our travelers also like this walkable area for its restaurants. Want to stretch your legs some more? Head to Bayfront Park and John McLaren Park, both nearby.
See properties

South San Francisco Convention Center

7.8/10 (668 reviews)
South San Francisco Convention Center is worth a visit, located 0.5 mi (0.8 km) from central South San Francisco. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander.
See properties

San Francisco Baking Institute

7.6/10 (423 reviews)
If you'd like to get a taste of South San Francisco student life, check out San Francisco Baking Institute in The East Side. Let yourself be amazed at the art galleries in the area— your cultural tour starts here. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. South San Francisco has lots of other significant landmarks you might want to visit such as Golden Gate Bridge.
See properties

See's Candies

8.0/10 (474 reviews)
See's Candies is 1.2 mi (2 km) from central South San Francisco, why not stop by during your stay. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. If you have fun at See's Candies, you'll love K1 Speed San Francisco, located nearby.
See properties

K1 Speed San Francisco

7.6/10 (330 reviews)
K1 Speed San Francisco is 1.1 mi (1.7 km) from central South San Francisco, why not stop by during your stay. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. If you have fun at K1 Speed San Francisco, you'll love See's Candies, located nearby.
See properties

South San Francisco Hillside Sign

If you're planning a bit of sightseeing head to South San Francisco Hillside Sign— just one of the monuments in Paradise Valley. South San Francisco has lots of other popular landmarks you might want to see such as Golden Gate Bridge.
See properties

Sign Hill Park

If you like quiet time surrounded by flowers and greenery, then make a stop at Sign Hill Park located 8.6 mi (13.8 km) from the center of San Francisco. Want to stretch your legs some more? Head to John McLaren Park and San Bruno Point Park, both nearby.
See properties

Learn more about South San Francisco

Look beyond the iconic 'South San Francisco The Industrial City' sign crowning Sign Hill Park for a city with its own distinct identity. Grand Avenue serves up a global feast of family-run eateries where locals debate the merits of each dumpling house. San Bruno Mountain offers hiking trails with sweeping Bay views that explain why residents tolerate the fog. See's Candies factory tours satisfy sweet tooths, while K1 Speed delivers indoor racing thrills. The Convention Center hosts events that draw visitors who are surprised to discover this isn't simply San Francisco's southern neighborhood. Despite tripling in population since World War II, 'South City' maintains its working-class roots while embracing its role as a Peninsula destination in its own right.

See all hotels in South San Francisco
A large, modern bridge with a unique design against a clear blue sky.
Photo by Tonette Pineda✈⛵🚌🚉🚃🚅🚀

Check out reviews of South San Francisco hotels guests love

Chancellor Hotel on Union Square

Chancellor Hotel on Union Square

10/10 Excellent
"Beautiful historic hotel - the room we were in was very clean and the amenities were nice and modern despite the age of the building. You can tell that this hotel is maintained with care. Great location and great price for the location as well!"
Megan 2-night trip
Posted 4 hours ago
Chancellor Hotel on Union Square
Stanford Court San Francisco

Stanford Court San Francisco

10/10 Excellent
"Nice place, just beware of all the destination fees. Bartender and front desk was good, food and drinks are over priced."
Jimmy 6-night trip
Posted 5 hours ago
Stanford Court San Francisco
Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point

10/10 Excellent
"Clean, staff was helpful. Enjoyed stay"
Dalia 3-night trip
Posted 6 hours ago
Embassy Suites by Hilton San Francisco Airport Oyster Point
DoubleTree by Hilton Hotel Berkeley Marina

DoubleTree by Hilton Hotel Berkeley Marina

10/10 Excellent
"Needs renovation. Other than that it was nice."
Clinton 1-night trip
Posted 6 hours ago
DoubleTree by Hilton Hotel Berkeley Marina
Hilton San Francisco Financial District

Hilton San Francisco Financial District

8/10 Good
"Fix the elevators !"
Marcia 1-night trip
Posted 1 day ago
Hilton San Francisco Financial District
Grand Hyatt San Francisco

Grand Hyatt San Francisco

10/10 Excellent
"The staff were pleasant and helpful, and the room very comfortable. The location is also very good."
Anita 1-night trip
Posted 2 days ago
Grand Hyatt San Francisco

Frequently asked questions

What accommodations do travelers like in South San Francisco?
Can I book refundable accommodations in South San Francisco?
If you need the flexibility to change your travel plans to South San Francisco, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow down the results.
Where can I stay in South San Francisco if I want a vacation rental instead of a hotel?
If you're looking for a good alternative to a hotel, review our selection of 26 vacation homes. In addition, you can choose from 12 apartments.
What will the weather in South San Francisco be like during my visit?
The warmest months in South San Francisco are usually September and August with an average temp of 62°F. February and January are the chilliest months when the average temp is 53°F. The rainiest months are December and January.
Why should I book my South San Francisco accommodation with Hotels.com?
There are lots of reasons to book your South San Francisco trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Keep exploring