Hotels in St. Charles

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Tonight
May 9 - May 10
Tomorrow
May 10 - May 11
Next weekend
May 15 - May 17
In two weeks
May 22 - May 24

Where to stay in St. Charles?

Panoramic House | Living area | Flat-screen TV
Big River Escape Grandview Manse
Big River Escape Grandview Manse
3.0 star property
Altura
10.0 out of 10, Exceptional, (4 reviews)
Enjoy serene Minnesota comfort with a fully-equipped kitchen and modern conveniences. Just a short drive from John Latsch State Park and Walnut Grove Golf Course, this cozy retreat offers free WiFi, parking and laundry facilities.
The price is $331
$355 total
includes taxes & fees
Jun 3 - Jun 4
Big River Escape Grandview Manse
In-room safe, desk, blackout drapes, iron/ironing board
Days Inn by Wyndham Winona
Days Inn by Wyndham Winona
2.0 star property
Winona
7.8 out of 10, Good, (1,001 reviews)
Wake up to free breakfast at this business-friendly Winona hotel, where a 24-hour fitness center keeps you energized. Just minutes from Remlinger Muscle Cars, enjoy clean rooms, helpful staff, and convenient parking near Mississippi River attractions.
The price is $68
$76 total
includes taxes & fees
May 12 - May 13
Days Inn by Wyndham Winona
Exterior
The Wen Inn formerly Andor Wenneson
The Wen Inn formerly Andor Wenneson
2.0 star property
Peterson
9.8 out of 10, Exceptional, (64 reviews)
This historic inn offers hiking and biking paths right outside your door, with free breakfast featuring local cuisine. Just minutes from Magelssen Bluff Park, guests enjoy complimentary WiFi, parking, and peaceful garden views.
The price is $98
$107 total
includes taxes & fees
May 25 - May 26
The Wen Inn formerly Andor Wenneson
Cabin, 1 Bedroom | Living area | 32-inch Smart TV with digital channels, TV, Netflix
Big River Escape Riverside Cabins
Big River Escape Riverside Cabins
3.0 star property
Cochrane
9.2 out of 10, Wonderful, (46 reviews)
Nestled along the Mississippi, this Cochrane retreat offers cabins with full kitchens and Smart TVs. Enjoy hiking trails and mountain biking nearby, then relax with Netflix after exploring Walnut Grove Golf Course or Danzinger Vineyards.
The price is $97
$103 total
includes taxes & fees
May 17 - May 18
Big River Escape Riverside Cabins
Studio Suite, 1 King Bed, Non Smoking | Desk, blackout drapes, iron/ironing board, free cribs/infant beds
AmericInn by Wyndham Winona
AmericInn by Wyndham Winona
3.0 star property
Winona
9.0 out of 10, Wonderful, (933 reviews)
Wake up to free breakfast at this Mississippi River hotel offering a hot tub for relaxation after workouts in the fitness center. The friendly staff earns praise from guests, while Remlinger Muscle Cars and Westfield Golf Club wait nearby. Free WiFi and parking round out your stay.
The price is $118
$132 total
includes taxes & fees
Jun 7 - Jun 8
AmericInn by Wyndham Winona
Front of property
Stone Mill Hotel & Suites
Stone Mill Hotel & Suites
3.0 star property
Lanesboro
9.2 out of 10, Wonderful, (675 reviews)
Nestled alongside a scenic golf course, this charming hotel offers complimentary breakfast, WiFi, and parking. Outdoor enthusiasts can explore nearby hiking trails, kayaking spots, and seasonal skiing, while cultural attractions and the praised staff enhance your countryside escape.
The price is $105
$113 total
includes taxes & fees
May 11 - May 12
Stone Mill Hotel & Suites
Exterior
Green Gables Inn
Green Gables Inn
2.0 star property
Lanesboro
9.6 out of 10, Exceptional, (79 reviews)
Nestled in Lanesboro with free continental breakfast served each morning, this welcoming inn offers complimentary WiFi and parking. Discover nearby Root River and Sylvan Park during your stay, with convenient access for outdoor adventures.
The price is $106
$114 total
includes taxes & fees
May 11 - May 12
Green Gables Inn
Family Cottage, Park View | Living area | 42-inch Smart TV with digital channels, streaming services, printers
Big River Escape Parkside Bungalow
Big River Escape Parkside Bungalow
3.0 star property
Winona
10.0 out of 10, Exceptional, (1 review)
Escape to this cozy cottage with easy access to hiking trails and a convenient 16-minute walk to Winona Station. Enjoy modern comforts including a Smart TV, washer/dryer, and printer while exploring nearby Huff Center and Altra Federal Credit Union Stadium.
The price is $206
$230 total
includes taxes & fees
May 10 - May 11
Big River Escape Parkside Bungalow
Lobby
The Rushford Inn
The Rushford Inn
3.0 star property
Rushford
8.0 out of 10, Very Good, (1 review)
The price is $159
$176 total
includes taxes & fees
May 18 - May 19
The Rushford Inn
Reception
Spark by Hilton Rochester South
Spark by Hilton Rochester South
3.0 star property
Rochester
9.4 out of 10, Exceptional, (465 reviews)
Within 10 minutes of Mayo Clinic, this welcoming Rochester hotel offers free breakfast, WiFi, and parking. Swim in the indoor pool, stay fit at the on-site gym, and experience friendly service that guests consistently praise.
The price is $77
$89 total
includes taxes & fees
Jun 7 - Jun 8
Spark by Hilton Rochester South
Exterior
Holiday Inn Express Rochester South - Mayo Area by IHG
Holiday Inn Express Rochester South - Mayo Area by IHG
2.5 star property
Rochester
8.8 out of 10, Excellent, (1,006 reviews)
Relax at this Rochester hotel just minutes from Mayo Clinic. Wake up to a free hot breakfast, unwind in the indoor pool, or keep up your routine at the fitness center. Clean rooms with fridges and microwaves offer comfort after hospital visits.
The price is $92
$106 total
includes taxes & fees
May 24 - May 25
Holiday Inn Express Rochester South - Mayo Area by IHG
Front of property
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3.0 star property
Rochester
7.4 out of 10, Good, (1,058 reviews)
Situated just a 10-minute drive from Mayo Clinic, this hotel offers a complimentary buffet breakfast each morning. Guests appreciate the spotless rooms, free WiFi, and parking. The fitness center and proximity to local attractions add extra value.
The price is $70
$80 total
includes taxes & fees
May 17 - May 18
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Serves lunch, dinner, and happy hour
AmericInn by Wyndham Rochester Near Mayo Clinic
AmericInn by Wyndham Rochester Near Mayo Clinic
3.0 star property
Rochester
8.2 out of 10, Very Good, (1,313 reviews)
Steps from Mayo Clinic, this tranquil hotel offers an indoor pool and on-site dining at Crooked Pint Ale House. Rooms include microwaves and refrigerators while the quiet environment ensures restful recovery. Free breakfast and parking add convenience.
The price is $77
$89 total
includes taxes & fees
May 17 - May 18
AmericInn by Wyndham Rochester Near Mayo Clinic
Property amenity
Carriage House B&B
Carriage House B&B
3.0 star property
Historic Downtown Winona
9.8 out of 10, Exceptional, (91 reviews)
This historic B&B offers complimentary full breakfast, WiFi, and parking. Just a 5-minute walk from Winona Station and near local attractions like Winona Public Library. Outdoor enthusiasts will appreciate the nearby hiking and biking trails for adventure.
The price is $124
$138 total
includes taxes & fees
Jun 1 - Jun 2
Carriage House B&B
Exterior
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (1,005 reviews)
Steps from Rochester Public Library and Shops University Square, this hotel offers peaceful rooms and a rooftop terrace. Enjoy American cuisine at Crave restaurant, grab snacks at the deli, or unwind at the bar after using the fitness center.
The price is $93
$107 total
includes taxes & fees
May 23 - May 24
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Reception
Hampton Inn Rochester-South
Hampton Inn Rochester-South
2.5 star property
Rochester
9.0 out of 10, Wonderful, (1,008 reviews)
Unwind in this tranquil retreat just 5 minutes from Mayo Clinic. After enjoying the free breakfast, take a refreshing dip in the indoor pool or relax in the hot tub. The helpful staff, free WiFi, and convenient parking enhance your stay near Apache Mall.
The price is $90
$104 total
includes taxes & fees
Jun 5 - Jun 6
Hampton Inn Rochester-South
Free daily full breakfast
Econo Lodge Mayo Clinic Area
Econo Lodge Mayo Clinic Area
2.0 star property
Rochester
9.0 out of 10, Wonderful, (971 reviews)
Wake up to a free full breakfast at this quiet hotel just 5 minutes from Mayo Clinic. Enjoy complimentary WiFi and parking, plus a 24-hour fitness center. The helpful staff and convenient location near Olmsted County Fairgrounds make this a peaceful choice.
The price is $70
$80 total
includes taxes & fees
May 31 - Jun 1
Econo Lodge Mayo Clinic Area
Interior detail
Birch Hill Suite Rochester – Med City
Birch Hill Suite Rochester – Med City
2.5 star property
Rochester
7.0 out of 10, Good, (36 reviews)
This modern Rochester hotel offers free WiFi and parking, plus a fitness center for health-conscious guests. Located within 10 minutes of Mayo Clinic and Saint Marys Campus, it's also near Marcus Cinema and Olmsted County Fairgrounds.
The price is $64
$74 total
includes taxes & fees
May 10 - May 11
Birch Hill Suite Rochester – Med City
Desk, laptop workspace, soundproofing, iron/ironing board
MainStay Suites Rochester South Mayo Clinic
MainStay Suites Rochester South Mayo Clinic
2.5 star property
Rochester
7.0 out of 10, Good, (109 reviews)
This extended-stay hotel offers free WiFi and parking only 10 minutes from Mayo Clinic. Spacious suites provide a home base while you're near major medical facilities, with Marcus Rochester Cinema and Olmsted County Fairgrounds close by.
The price is $59
$68 total
includes taxes & fees
May 17 - May 18
MainStay Suites Rochester South Mayo Clinic
Iron/ironing board, free cribs/infant beds, free WiFi, bed sheets
Baymont by Wyndham Rochester Mayo Clinic Area
Baymont by Wyndham Rochester Mayo Clinic Area
2.5 star property
Rochester
7.2 out of 10, Good, (778 reviews)
The price is $64
$73 total
includes taxes & fees
May 17 - May 18
Baymont by Wyndham Rochester Mayo Clinic Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about St. Charles

St. Charles is well-known for its attractions such as Whitewater State Park and Whitewater River.

See all hotels in St. Charles
St. Charles is a rural Community in South East Minnesota

Check out reviews of St. Charles hotels guests love

Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

10/10 Excellent
"Clean, friendly staff, comfortable beds. Close to Mayo Clinic and many places for dining. And a good price."
Dawn 2-night trip
Posted 1 hour ago
Med City Inn & Suites - Mayo Clinic Area

Frequently asked questions

What accommodations do travelers recommend in St. Charles?
White Valley Motel is an accommodation that is popular with guests.
Can I book refundable accommodations in St. Charles?
If you need the flexibility to change your plans to St. Charles, most properties provide refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in St. Charles be like during my vacation?
July and August are typically the warmest months in St. Charles when the average temp is 67°F. January and February are the coldest months when the average temperature is 22°F. June and May are the months with the most rain.
Why should I book my St. Charles accommodation with Hotels.com?
There are plenty of reasons to book your St. Charles travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.