An aerial view of a town with industrial buildings, roads, and green areas.

Hotels in St. Charles

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Where to stay in St. Charles?

A hotel room with a large bed, a desk with a chair, a window with a view of the outdoors, and two bedside lamps.

A reception desk with a wooden finish, a large illuminated 'C' sign, and a modern light fixture on the ceiling.

A laundry area with two Whirlpool washers and a dryer, a wooden shelf above, and a white ceiling.

A modern living room with a sofa, two armchairs, a coffee table, and a large window offering a view of the outdoors.

1. Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

$83

$96 total

includes taxes & fees

Nov 2 - Nov 3

A two-story house with a porch and a covered entryway.

A room with two patterned sofas, a small table with a lamp, and a window with curtains.

A porch with a white door labeled "WENNESON" and a welcome wreath.

A hallway with a wooden floor, a chandelier, a bust sculpture, and a door leading to another room.

2. The Wen Inn formerly Andor Wenneson

Peterson

$105

$114 total

includes taxes & fees

Oct 7 - Oct 8

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

A reception area with a wooden reception desk, a red doormat, and framed awards on the wall.

A compact laundry area with a washing machine, dryer, and a water fountain.

3. Econo Lodge Mayo Clinic Area

Rochester

$70

$81 total

includes taxes & fees

Nov 1 - Nov 2

An outdoor seating area with wicker chairs and tables, surrounded by vibrant flowers and a red umbrella.

A rustic bar area with wooden beams, a wooden counter, and sacks of grain.

A spacious living area with a high ceiling, wooden beams, a blue armchair, a sofa, and a glass coffee table.

A cozy living room with a fireplace, a staircase, and a dining area.

4. Stone Mill Hotel & Suites

Lanesboro

$105

$113 total

includes taxes & fees

Oct 18 - Oct 19

A modern hotel lobby with a reception desk, seating area, and a kitchenette.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

A hotel with a covered entrance, multiple floors, and a parking lot.

A small, well-organized pantry with shelves stocked with snacks and beverages.

5. Spark by Hilton Rochester South

Rochester

$87

$100 total

includes taxes & fees

Nov 1 - Nov 2

A multi-story building with a balcony, surrounded by various potted plants and flowers.

A porch with a variety of potted plants and flowers, a sign reading "OFFICE Welcome to Green Gables," and a door with a green doorbell.

A bedroom with a four-poster bed, a sitting area with a sofa, a small table with a vase, and a bathtub.

An outdoor patio with tables and chairs, green umbrellas, and a wooden deck.

6. Green Gables Inn

Lanesboro

$94

$101 total

includes taxes & fees

Oct 25 - Oct 26

A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

A buffet counter with a variety of food items, a coffee station, and a beverage dispenser.

An indoor swimming pool with a slide, seating areas, and a lifeguard station.

A modern lobby with a teal sofa, yellow chairs, a small round table, and a fireplace with a TV.

7. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Rochester

$71

$82 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with a large bed, a television, a desk, and a window with curtains.

A lobby with two leather armchairs, a welcome sign, and a lamp on a small table.

A compact kitchen with a refrigerator, microwave, and sink. There's a small dining table with a chair.

A hotel lobby with a reception desk, a 'WELCOME' sign, a seating area, and a buffet counter.

8. MainStay Suites Rochester South Mayo Clinic

Rochester

$61

$70 total

includes taxes & fees

Oct 11 - Oct 12

A modern hotel lobby with a reception desk, seating area, and a dining space.

A Holiday Inn Express building with a stone facade and illuminated signage.

A modern hotel room with a wooden desk, orange chair, dark sofa, and a small table.

A modern breakfast area with a counter displaying various food items, a water dispenser, and a sign indicating a bakery section.

9. Holiday Inn Express Rochester South - Mayo Area by IHG

Rochester

$105

$121 total

includes taxes & fees

Oct 10 - Oct 11

A hotel room with a large bed, a desk with a chair, a television, and a view of the outdoors through a door.

A breakfast corner with a counter, seating area, and a red partition.

A hotel room with a large bed, a desk, a chair, and a TV.

An indoor swimming pool with clear blue water, a ladder, and blue chairs around the pool.

10. Baymont by Wyndham Rochester Mayo Clinic Area

Rochester

$60

$69 total

includes taxes & fees

Oct 25 - Oct 26

A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.

A hotel room with two beds, a desk, a chair, and a mirror.

An indoor swimming pool with a slide, seating area, and a large frog statue.

A modern kitchen with wooden cabinets, a microwave, an oven, and a dishwasher.

11. AmericInn by Wyndham Rochester Near Mayo Clinic

Rochester

$73

$84 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with two beds, a large landscape painting above the headboard, a bedside table with a phone, and a blue patterned rug.

A gym with treadmills, an elliptical, and a stationary bike.

A reception area with a counter, a clock, a desk with a computer, and a framed picture on the wall.

A modern room with two sofas, a coffee table, and large windows with curtains.

12. Days Inn by Wyndham Winona

Winona

$68

$76 total

includes taxes & fees

Nov 1 - Nov 2

13. Birch Hill Suite Rochester – Med City

Rochester

$64

$74 total

includes taxes & fees

Oct 5 - Oct 6

A hotel room with a large bed, a separate bathroom with a bathtub, a desk with a chair, and a large mirror.

A hotel room with a sofa, a small table, a TV, a microwave, and a door.

An indoor swimming pool with clear water, a lifeguard on duty sign, and a seating area with chairs and tables.

A hotel lobby with seating, a fireplace, a clock, and a reception area.

14. AmericInn by Wyndham Winona

Winona

$118

$132 total

includes taxes & fees

Oct 11 - Oct 12

A hotel lobby with a reception desk, seating area, and a bar.

A front-loading white washer and dryer in a laundry room with a window and a door.

A multi-story hotel with a grey and orange facade, a covered entrance, and a parking lot with marked spaces.

A hotel room with two beds, a desk, a TV, and a large window with curtains.

15. Super 8 by Wyndham Rochester Mayo Clinic Area

Rochester

$51

$59 total

includes taxes & fees

Oct 11 - Oct 12

A spacious outdoor dining area with modern furniture and large windows offering views of the city.

A reception desk with a modern design, featuring a wooden panel and a wall adorned with framed botanical artwork.

An outdoor dining area with wooden beams, tables, and chairs.

A modern hotel room with a large bed, a sofa, a small table, a desk, and a wardrobe.

16. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester

$107

$123 total

includes taxes & fees

Oct 23 - Oct 24

An indoor swimming pool with slides, seating areas, and a covered section with umbrellas.

A modern kitchen with black cabinets, white countertops, and a tiled backsplash. There are pendant lights, a refrigerator, and a coffee machine.

A modern kitchen with a microwave, sink, and granite countertop.

A hotel room with a kitchen area, a bed, a TV, and a seating area.

17. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Rochester

$95

$109 total

includes taxes & fees

Oct 9 - Oct 10

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A restaurant interior with wooden tables, chairs, and a stone wall.

A modern living room with a dark wall, a decorative light fixture, and a patterned wall art piece.

A garden with a water feature, rocks, and yellow umbrellas.

18. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Historic Southwest

$104

$120 total

includes taxes & fees

Oct 18 - Oct 19

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

A compact kitchen with a microwave, refrigerator, and coffee maker. A small bar stool is near the counter.

A hotel room with a large bed, bedside tables, a mirror, and a patterned carpet.

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

19. Quality Inn & Suites Mayo Clinic Area

Rochester

$76

$89 total

includes taxes & fees

Nov 1 - Nov 2

A display of ceramic mugs and bowls on a table with a white tablecloth, illuminated by string lights.

A kitchen with wooden cabinets, a granite countertop, and a built-in microwave.

A spacious room with a high ceiling, wooden beams, and a large window displaying a sign for The Rushford Inn.

20. The Rushford Inn

Rushford

$159

$171 total

includes taxes & fees

Oct 5 - Oct 6

View all properties

Go beyond your typical stay in St. Charles

Learn more about St. Charles

St. Charles is well-known for its attractions such as Whitewater State Park and Whitewater River.

See all hotels in St. Charles

Check out reviews of St. Charles hotels guests love

The Wen Inn formerly Andor Wenneson

Peterson

10/10 Exceptional

Marcia

Green Gables Inn

Lanesboro

10/10 Exceptional

RICHARD

Stone Mill Hotel & Suites

Lanesboro

10/10 Exceptional

Michael

A table set for a meal with various dishes, glasses of orange juice, and a vase with flowers.

A spacious room with wooden paneling, a chandelier, a fireplace, and a large rug.

A grand staircase with a floral carpet, wooden balustrades, and a chandelier.

A room with a portrait framed in gold, red curtains, and a table with ornate candle holders.

Alexander Mansion Bed and Breakfast

Historic Downtown Winona

10/10 Exceptional

We stayed in the Alexander Suite, which was ideal for us. King size bed, Victorian charm, tidy bathroom with tub, shower and amenities. Enjoyed the Watkins lotion. The room has an adjacent sitting room perfect for coffee, tea, or relaxing. Don't forget to write something in the journal. The host, Richard, is super nice and so knowledgeable about the area. The huge breakfast consists of 5 courses. Fruit parfait, fresh baked bread that is to die for. The blueberry was our favorite. The main...

Laila and David

Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

10/10 Exceptional

Wendy

A cozy living room with a fireplace, a sofa, a coffee table, and a view through large windows.

A garden with a pergola, a wooden table, and a variety of plants.

A white two-story house with green shutters, a porch, and a sign that reads "Bed & Breakfast."

A dining room with a long wooden table set for a meal, surrounded by chairs.

Carriage House B&B

Historic Downtown Winona

10/10 Exceptional

Anonymous traveler

Econo Lodge Mayo Clinic Area

Rochester

10/10 Exceptional

Eileen

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester

10/10 Exceptional

Jay

A hotel room with two beds, a desk, a chair, and a lamp.

A swimming pool with a capacity sign, a lifeguard warning sign, and a spa rules sign.

A hotel lobby with a dining area, a fireplace, and a television displaying a map.

A lobby with a checkered floor, two blue armchairs, a table with a lamp, and a 'WELCOME' sign.

Country Trails Inn & Suites

Preston

10/10 Exceptional

Jean

The Rushford Inn

Rushford

10/10 Exceptional

Bonnie

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

A modern lounge area with a sofa, chairs, and tables.

A modern hotel room with a bed, desk, and kitchenette.

Home2 Suites by Hilton Rochester Mayo Clinic Area

Rochester

10/10 Exceptional

Mary

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A Fairfield Inn & Suites hotel with a modern design, featuring a prominent entrance and a parking area.

A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park

10/10 Exceptional

Donald

A modern outdoor seating area with a built-in fireplace, two wooden chairs, a table, and a sofa.

A gym with various exercise equipment, including treadmills, stationary bikes, and weight machines.

A modern urban street with tall buildings, a pedestrian walkway, and a parking area.

A modern kitchen with a central island, bar stools, and pendant lighting. A living area with a sofa, ottoman, and a view of the outdoors is visible.

Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kutzky Park

10/10 Exceptional

Rachel

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

Hampton Inn Rochester-South

Rochester

10/10 Exceptional

JKathleen

A modern indoor patio with a fire feature, seating, and large windows.

A modern hotel lobby with a large glass wall, a green wall mural, and a seating area with sofas and chairs.

A modern interior with a seating area, a bookshelf, and a window with a view of trees.

A reception area with a curved reception desk, wooden shelving, and a green moss wall with the text "I ♥ EVEN".

EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park

10/10 Exceptional

ryan

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern bar area with seating and a counter.

A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.

A modern indoor pool area with lounge chairs and a pool.

Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester

10/10 Exceptional

Chad

Holiday Inn Express Rochester South - Mayo Area by IHG

Rochester

10/10 Exceptional

Craig

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

A modern lounge area with seating, a fireplace, and a bar area.

A modern hotel with a flat roof, multiple windows, and a covered outdoor seating area.

An outdoor patio area with wicker furniture, a central fire feature, and a stone building in the background.

Residence Inn by Marriott Rochester Mayo Clinic Area South

Rochester

10/10 Exceptional

Jaci

Frequently Asked Questions

What accommodations do travelers recommend in St. Charles?

White Valley Motel is an accommodation that is popular with guests.

Can I book refundable accommodations in St. Charles?

If you need the flexibility to change your plans to St. Charles, most properties provide refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in St. Charles be like during my vacation?

July and August are typically the warmest months in St. Charles when the average temp is 67°F. January and February are the coldest months when the average temperature is 22°F. June and May are the months with the most rain.

Why should I book my St. Charles accommodation with Hotels.com?

There are plenty of reasons to book your St. Charles travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.