Hotels in St. Charles

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Where to stay in St. Charles?

White Valley Motel
White Valley Motel
2.5 star property
St. Charles
5.6 out of 10, (129 reviews)
  • cleanliness
    Cozy riverside motel in St. Charles with easy access to Whitewater River.
The price is $69
$77 total
includes taxes & fees
Feb 1 - Feb 2
White Valley Motel
Days Inn by Wyndham Winona
Days Inn by Wyndham Winona
2.0 star property
Winona
7.8 out of 10, Good, (1,001 reviews)
  • cleanliness
    Modern Days Inn by the Mississippi with complimentary amenities and fitness.
The price is $68
$76 total
includes taxes & fees
Feb 2 - Feb 3
Days Inn by Wyndham Winona
AmericInn by Wyndham Winona
AmericInn by Wyndham Winona
2.5 star property
Winona
9.0 out of 10, Wonderful, (905 reviews)
  • cleanliness
    Stay minutes from Winona State University with hot tub and complimentary perks.
The price is $103
$115 total
includes taxes & fees
Feb 8 - Feb 9
AmericInn by Wyndham Winona
The Wen Inn formerly Andor Wenneson
The Wen Inn formerly Andor Wenneson
2.0 star property
Peterson
9.8 out of 10, Exceptional, (57 reviews)
  • cleanliness
    Escape to a charming inn adjacent to Peterson's golf course, with hiking trails nearby.
The price is $98
$107 total
includes taxes & fees
Feb 15 - Feb 16
The Wen Inn formerly Andor Wenneson
Big River Escape Riverside Cabins
Big River Escape Riverside Cabins
3.0 star property
Cochrane
9.2 out of 10, Wonderful, (42 reviews)
  • cleanliness
    Unwind in riverside cabins with kitchen convenience, just minutes from Mississippi River.
The price is $124
$130 total
includes taxes & fees
Feb 24 - Feb 25
Big River Escape Riverside Cabins
Stone Mill Hotel & Suites
Stone Mill Hotel & Suites
3.0 star property
Lanesboro
9.2 out of 10, Wonderful, (664 reviews)
  • cleanliness
    Experience the serenity of countryside living at this golf-adjacent retreat in Lanesboro.
The price is $105
$113 total
includes taxes & fees
Feb 1 - Feb 2
Stone Mill Hotel & Suites
Holiday Inn Express Rochester South - Mayo Area by IHG
Holiday Inn Express Rochester South - Mayo Area by IHG
2.5 star property
Rochester
8.8 out of 10, Excellent, (1,002 reviews)
  • cleanliness
    Modern rooms near Mayo Clinic with indoor pool and free hot breakfast daily.
The price is $69
$79 total
includes taxes & fees
Feb 6 - Feb 7
Holiday Inn Express Rochester South - Mayo Area by IHG
Spark by Hilton Rochester South
Spark by Hilton Rochester South
3.0 star property
Rochester
9.4 out of 10, Exceptional, (366 reviews)
  • cleanliness
    Cozy lodging near Mayo Clinic with complimentary breakfast and indoor pool access.
The price is $71
$81 total
includes taxes & fees
Feb 8 - Feb 9
Spark by Hilton Rochester South
Hampton Inn Rochester-South
Hampton Inn Rochester-South
2.5 star property
Rochester
9.0 out of 10, Wonderful, (1,006 reviews)
  • cleanliness
    Peaceful hotel near Mayo Clinic with indoor pool and daily complimentary breakfast.
The price is $82
$95 total
includes taxes & fees
Feb 22 - Feb 23
Hampton Inn Rochester-South
Econo Lodge Mayo Clinic Area
Econo Lodge Mayo Clinic Area
2.0 star property
Rochester
9.0 out of 10, Wonderful, (929 reviews)
  • cleanliness
    Restful retreat near Mayo Clinic with 24-hour fitness center and complimentary perks.
The price is $63
$72 total
includes taxes & fees
Feb 13 - Feb 14
Econo Lodge Mayo Clinic Area
Big River Escape Parkside Bungalow
Big River Escape Parkside Bungalow
3.0 star property
Winona
10.0 out of 10, Exceptional, (1 review)
  • cleanliness
    Quiet cottage retreat near Winona Station with free WiFi and parking.
The price is $206
$230 total
includes taxes & fees
Feb 3 - Feb 4
Big River Escape Parkside Bungalow
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3.0 star property
Rochester
7.2 out of 10, Good, (1,031 reviews)
  • cleanliness
    Convenient location near Mayo Clinic with free daily breakfast and on-site fitness.
The price is $72
$83 total
includes taxes & fees
Feb 1 - Feb 2
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (924 reviews)
  • cleanliness
    Relax in quiet comfort with Mayo Clinic just a 15-minute walk away from this hotel.
The price is $99
$114 total
includes taxes & fees
Feb 21 - Feb 22
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Quality Inn & Suites Mayo Clinic Area
Quality Inn & Suites Mayo Clinic Area
2.5 star property
Rochester
8.8 out of 10, Excellent, (845 reviews)
  • cleanliness
    Quiet refuge in Rochester's medical district with free hot breakfast daily.
The price is $64
$74 total
includes taxes & fees
Feb 14 - Feb 15
Quality Inn & Suites Mayo Clinic Area
Hilton Garden Inn Rochester Downtown, MN
Hilton Garden Inn Rochester Downtown, MN
3.0 star property
Downtown Rochester
8.8 out of 10, Excellent, (869 reviews)
  • cleanliness
    A welcoming downtown haven near Mayo Clinic with indoor pool and hot tub.
The price is $107
$123 total
includes taxes & fees
Feb 6 - Feb 7
Hilton Garden Inn Rochester Downtown, MN
Baymont by Wyndham Rochester Mayo Clinic Area
Baymont by Wyndham Rochester Mayo Clinic Area
2.5 star property
Rochester
7.0 out of 10, Good, (733 reviews)
The price is $60
$69 total
includes taxes & fees
Feb 5 - Feb 6
Baymont by Wyndham Rochester Mayo Clinic Area
Country Inn & Suites Rochester South Mayo Clinic
Country Inn & Suites Rochester South Mayo Clinic
3.0 star property
Rochester
8.4 out of 10, Very Good, (1,002 reviews)
  • cleanliness
    A peaceful Mayo Clinic escape with complimentary hot breakfast and tranquil pool area.
The price is $84
$97 total
includes taxes & fees
Feb 22 - Feb 23
Country Inn & Suites Rochester South Mayo Clinic
AmericInn by Wyndham Rochester Near Mayo Clinic
AmericInn by Wyndham Rochester Near Mayo Clinic
3.0 star property
Rochester
8.0 out of 10, Very Good, (1,197 reviews)
  • cleanliness
    Peaceful retreat near Mayo Clinic with serene atmosphere and indoor pool.
The price is $74
$85 total
includes taxes & fees
Feb 22 - Feb 23
AmericInn by Wyndham Rochester Near Mayo Clinic
Birch Hill Suite Rochester – Med City
Birch Hill Suite Rochester – Med City
2.5 star property
Rochester
7.6 out of 10, Good, (12 reviews)
  • cleanliness
    Stylish retreat close to Mayo Clinic with thoughtful traveler amenities.
The price is $54
$63 total
includes taxes & fees
Feb 8 - Feb 9
Birch Hill Suite Rochester – Med City
MainStay Suites Rochester South Mayo Clinic
MainStay Suites Rochester South Mayo Clinic
2.5 star property
Rochester
7.0 out of 10, Good, (94 reviews)
  • cleanliness
    Wake up just minutes from Mayo Clinic in comfort at this all-suite Rochester hotel.
The price is $56
$64 total
includes taxes & fees
Feb 1 - Feb 2
MainStay Suites Rochester South Mayo Clinic
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about St. Charles

St. Charles is well-known for its attractions such as Whitewater State Park and Whitewater River.

St. Charles is a rural Community in South East Minnesota

Check out reviews of St. Charles hotels guests love

Frequently asked questions

What accommodations do travelers recommend in St. Charles?
White Valley Motel is an accommodation that is popular with guests.
Can I book refundable accommodations in St. Charles?
If you need the flexibility to change your plans to St. Charles, most properties provide refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in St. Charles be like during my vacation?
July and August are typically the warmest months in St. Charles when the average temp is 67°F. January and February are the coldest months when the average temperature is 22°F. June and May are the months with the most rain.
Why should I book my St. Charles accommodation with Hotels.com?
There are plenty of reasons to book your St. Charles travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.