Hotels in South Main
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Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.0 out of 10, Good, (1,298 reviews)
The price is $99
$116 total
includes taxes & fees
Jul 12 - Jul 13

Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,003 reviews)
The price is $71
$83 total
includes taxes & fees
Jul 5 - Jul 6

Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,008 reviews)
The price is $59
$69 total
includes taxes & fees
Jul 19 - Jul 20

Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,001 reviews)
The price is $109
$127 total
includes taxes & fees
Jul 18 - Jul 19

Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (872 reviews)
The price is $74
$87 total
includes taxes & fees
Jul 12 - Jul 13

Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.2 out of 10, Wonderful, (292 reviews)
The price is $79
$93 total
includes taxes & fees
Jul 12 - Jul 13

Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook16.8 km from South Main
9.4 out of 10, Exceptional, (179 reviews)
The price is $109
$132 total
includes taxes & fees
Jul 7 - Jul 8

Studio 6 Houston, TX – Pearland/Medical Center
Studio 6 Houston, TX – Pearland/Medical CenterSoutheast Houston, 12.9 km from South Main
9.4 out of 10, Exceptional, (120 reviews)
The price is $62
$72 total
includes taxes & fees
Jun 30 - Jul 1

Crystal Inn Northeast Houston Downtown I-610
Crystal Inn Northeast Houston Downtown I-610Northside, 18.9 km from South Main
8.4 out of 10, Very Good, (227 reviews)
The price is $76
$89 total
includes taxes & fees
Jun 21 - Jun 22

Hotel Royale
Hotel Royale20.9 km from South Main
9.0 out of 10, Wonderful, (42 reviews)
The price is $90
$105 total
includes taxes & fees
Jun 21 - Jun 22

Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,003 reviews)
The price is $87
$101 total
includes taxes & fees
Jul 6 - Jul 7

Downtowner Inns - Houston Downtown
Downtowner Inns - Houston DowntownMidtown, 9.1 km from South Main
9.2 out of 10, Wonderful, (169 reviews)
The price is $96
$112 total
includes taxes & fees
Jun 21 - Jun 22

Doubletree by Hilton Houston Hobby Airport
Doubletree by Hilton Houston Hobby AirportSoutheast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,006 reviews)
The price is $98
$115 total
includes taxes & fees
Jul 9 - Jul 10

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG30.8 km from South Main
9.0 out of 10, Wonderful, (1,004 reviews)
The price is $87
$102 total
includes taxes & fees
Jul 6 - Jul 7

Courtyard by Marriott Houston Intercontinental Airport
Courtyard by Marriott Houston Intercontinental Airport31.8 km from South Main
9.0 out of 10, Wonderful, (1,231 reviews)
The price is $118
$138 total
includes taxes & fees
Jul 6 - Jul 7

La Quinta Inn & Suites by Wyndham Houston Bush IAH South
La Quinta Inn & Suites by Wyndham Houston Bush IAH South31.2 km from South Main
8.0 out of 10, Very Good, (2,148 reviews)
The price is $80
$93 total
includes taxes & fees
Jul 7 - Jul 8

Hampton Inn & Suites Houston Sugar Land
Hampton Inn & Suites Houston Sugar Land23.4 km from South Main
8.8 out of 10, Excellent, (689 reviews)
The price is $97
$111 total
includes taxes & fees
Jul 6 - Jul 7

Sonesta Simply Suites Houston – NASA Clear Lake
Sonesta Simply Suites Houston – NASA Clear LakeNassau Bay, 31.8 km from South Main
8.2 out of 10, Very Good, (1,003 reviews)
The price is $65
$76 total
includes taxes & fees
Jun 21 - Jun 22

Palace Inn Blue 290 W 43rd & Bingle Rd
Palace Inn Blue 290 W 43rd & Bingle Rd19.4 km from South Main
9.0 out of 10, Wonderful, (77 reviews)
The price is $86
$101 total
includes taxes & fees
Jul 17 - Jul 18

Hampton Inn & Suites Houston-Bush Intercontinental Aprt
Hampton Inn & Suites Houston-Bush Intercontinental Aprt31.8 km from South Main
8.8 out of 10, Excellent, (1,916 reviews)
The price is $89
$104 total
includes taxes & fees
Jul 11 - Jul 12
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
![]() Candlewood Suites Houston Medical Center by IHG | 7.4 Good 872 reviews | View | ||||||
![]() Wyndham Houston near NRG Park/Medical Center | 7.0 Good 1,298 reviews | View | ||||||
![]() Wingate Houston near NRG Park/Medical Center | 6.6 1,003 reviews | View | ||||||
![]() Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,001 reviews | View | ||||||
![]() Quality Inn & Suites NRG Park - Medical Center | 6.6 1,008 reviews | View |
Check out reviews of South Main hotels guests love

Hilton Houston Plaza/Medical Center
10/10 Excellent
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