Hotels in South Main

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Tonight
Sep 12 - Sep 13
Tomorrow
Sep 13 - Sep 14
Next weekend
Sep 18 - Sep 20
In two weeks
Sep 25 - Sep 27

Where to stay in South Main?

A modern lobby with a blue carpet, seating area, and large windows.
A hotel room with two beds, a nightstand with lamps, a window with curtains, and a framed picture on the wall.
A lobby with a bar area, leather seating, and a stone wall.
A spacious hall with a patterned carpet, a red curtain backdrop, and a grand chandelier.

1. Wyndham Houston at Reliant Park & Medical Center

Wyndham Houston at Reliant Park & Medical Center
South Main
United States
Luis
$94
$110 total
includes taxes & fees
Sep 24 - Sep 25
Wyndham Houston at Reliant Park & Medical Center
A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.
A Comfort Suites hotel entrance with a covered walkway, a sign, and a parking area.
A spacious lobby with a high ceiling, two blue sofas with red cushions, a patterned carpet, and a glass railing overlooking a lower level.
A spacious lobby with a reception desk, two sofas, a coffee station, and large windows providing natural light.

2. Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
South Main
United States
LaKeisha
$95
$111 total
includes taxes & fees
Sep 21 - Sep 22
Comfort Suites Houston near Medical Center- NRG Stadium
A hotel room with a blue sofa, striped armchair, a small table, a TV on a cabinet, a microwave, and a door leading to a bedroom.
A vending machine and a Coca-Cola refrigerator in a hallway with tiled flooring and a ceiling with fluorescent lights.
A self-service breakfast bar with a coffee machine, cereal dispensers, and a refrigerated display.
A lobby with a black leather sofa, wooden coffee table, and two upholstered chairs. A reception desk is visible in the background.

3. Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
South Main
United States
HERBERT
$67
$79 total
includes taxes & fees
Oct 12 - Oct 13
Quality Inn & Suites NRG Park - Medical Center
A compact kitchen with dark cabinets, a microwave, a coffee maker, and a white countertop. There are two wicker chairs and a small table.
A compact kitchen with a dining table, chairs, a coffee maker, and a refrigerator.
A neatly made bed with a patterned bedspread, two bedside lamps, and a nightstand with a small item on it.
A hotel room with a bed, a sofa, a table, a framed picture on the wall, and a bathroom visible through an open door.

4. Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
South Main
United States
Barbara
$78
$91 total
includes taxes & fees
Sep 21 - Sep 22
Candlewood Suites Houston Medical Center by IHG
A spacious dining area with multiple tables and chairs, large windows, and hanging pendant lights.
A modern lobby with seating areas, a reception desk, and a view of the outside.
A Holiday Inn Express & Suites hotel with a glass entrance, multiple floors, and a view of the surrounding neighborhood.
A coffee station with two coffee machines and a variety of coffee pods and cups.

5. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
1.4 km from South Main
United States
Juan
$118
$139 total
includes taxes & fees
Sep 17 - Sep 18
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.
A spacious indoor area with high ceilings, large windows, and modern furniture.
A multi-story hotel with a rooftop pool area, featuring a modern design and multiple balconies.
A modern reception area with a wooden reception desk, a coffee machine, and a seating area with a sofa and armchairs.

6. Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center
Texas Medical Center, 3.1 km from South Main
United States
Marcus
$127
$149 total
includes taxes & fees
Oct 5 - Oct 6
Hyatt Place Houston Medical Center
A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.
A spacious indoor area with high ceilings, large windows, and modern furniture.
A hotel room with a large bed, a flat-screen TV, a painting on the wall, and a view of the city through large windows.
A modern bar area with a long counter, multiple bar stools, and a variety of bottles and glasses.

7. Hyatt House Houston Medical Center

Hyatt House Houston Medical Center
Texas Medical Center, 3.1 km from South Main
United States
estella
$134
$158 total
includes taxes & fees
Sep 28 - Sep 29
Hyatt House Houston Medical Center
A bar area with a long counter, bar stools, a refrigerated display case with beverages, and a menu board above the counter.
A Courtyard by Marriott hotel with a central courtyard, multiple floors, and a parking lot.
A hotel pool area with a bar, seating, and a view of the building's exterior.
A modern living room with a sectional sofa, a round coffee table, and a comfortable seating area with armchairs.

8. Courtyard By Marriott Houston Medical Center Reliant Park

Courtyard By Marriott Houston Medical Center Reliant Park
2.7 km from South Main
United States
Meredith
$112
$132 total
includes taxes & fees
Sep 17 - Sep 18
Courtyard By Marriott Houston Medical Center Reliant Park
A modern restaurant with a bar area, wooden flooring, and a variety of seating options including tables and chairs.
A living room with a black leather sofa, a round coffee table with a vase, and a patterned rug.
A restaurant with wooden tables and chairs, a bar area, and a green wall with a TV.
A modern interior with a seating area, a bar with a green wall, and a window with artwork.

9. Hotel Ylem

Hotel Ylem
2.3 km from South Main
United States
Monica
$73
$91 total
includes taxes & fees
Sep 22 - Sep 23
Hotel Ylem
A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.
A modern lobby with seating areas, a reception desk, and decorative wall art.
An outdoor patio area with seating and a pool.
A dining table set with plates, cutlery, glasses, and candles, surrounded by chairs in a formal dining area.

10. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
Texas Medical Center, 4.4 km from South Main
United States
Tracey
$106
$125 total
includes taxes & fees
Oct 11 - Oct 12
Hilton Houston Plaza/Medical Center
An outdoor patio area with round wooden tables and wicker chairs, featuring a lantern and modern lighting fixtures.
A modern dining area with multiple tables and chairs, a buffet setup, and overhead lighting fixtures.
A modern lobby with a grey sofa, orange ottoman, and a large TV screen.
A pool area with lounge chairs and a swimming pool.

11. Hilton Garden Inn Houston Medical Center, TX

Hilton Garden Inn Houston Medical Center, TX
Texas Medical Center, 4.7 km from South Main
United States
Amy
$114
$133 total
includes taxes & fees
Sep 24 - Sep 25
Hilton Garden Inn Houston Medical Center, TX
A spacious lobby with plush seating, a marble coffee table, and a grand chandelier.
A modern hotel room with a sofa, armchair, and a TV mounted on the wall.
A hotel room with two beds, a desk, a chair, a TV, and a large window offering a city view.
A modern bar area with a sign reading "BLOSSOM Houston" and a variety of liquor bottles. There are plush seating arrangements and a decorative fountain in the foreground.

12. Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
Texas Medical Center, 3.5 km from South Main
United States
Samantha
$162
$190 total
includes taxes & fees
Oct 12 - Oct 13
Blossom Hotel Houston, Curio Collection by Hilton
An outdoor patio area with round wooden tables and wicker chairs, featuring a lantern and modern lighting fixtures.
A dining area with a table set for two, a potted plant, and a view into the living room.
A self-service beverage and snack station with refrigerated drinks, snacks, and a variety of packaged goods.
A modern lobby with a grey sofa, orange ottomans, a round coffee table, and a large TV screen.

13. Home2 Suites by Hilton Houston Medical Center, TX

Home2 Suites by Hilton Houston Medical Center, TX
Texas Medical Center, 4.7 km from South Main
United States
Jason
$130
$153 total
includes taxes & fees
Sep 25 - Sep 26
Home2 Suites by Hilton Houston Medical Center, TX
A rooftop pool area with lounge chairs and a view of a tall building at night.
A rooftop terrace with outdoor seating, a pool, and city views.
A modern hotel with a prominent glass facade, a flat roof, and a ground-level entrance with a covered walkway.
A modern hotel lobby with wooden flooring, contemporary chairs, and illuminated ceiling panels.

14. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
Texas Medical Center, 4.4 km from South Main
United States
Jennifer Noel
$137
$170 total
includes taxes & fees
Sep 27 - Sep 28
The Westin Houston Medical Center/Museum District
A spacious living area with a dining table, chairs, and a chandelier.
A restaurant with tables set for dining, surrounded by wicker chairs and potted plants.
A modern hotel room with a large window, a sofa, a coffee table, and a dining area.
A hotel room with a bed, a nightstand, a desk with a chair, a large mirror, and a chandelier.

15. Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
6.3 km from South Main
United States
Justus
$276
$362 total
includes taxes & fees
Sep 14 - Sep 15
Hotel Zaza Houston Museum District
A person sitting on a white lounge chair with a striped towel, reading a book.
A modern hotel room with a wooden desk, yellow chair, and a sofa with cushions. There is a round mirror on the wall and a painting above the sofa.
A hotel lobby with a modern design, featuring a reception desk, seating area, and a large window.
A bar area with a long counter, multiple shelves with bottles, and a television screen.

16. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Crowne Plaza Houston Med Ctr-Galleria Area by IHG
Greenway Plaza-Upper Kirby, 6.5 km from South Main
United States
Julie
$71
$84 total
includes taxes & fees
Sep 17 - Sep 18
Crowne Plaza Houston Med Ctr-Galleria Area by IHG
A modern living room with a glass table, a sofa, a TV, and a staircase with a city view.
A modern urban landscape with high-rise buildings, a well-maintained road, and green spaces.
A modern hotel lobby with a sofa, dining area, and large windows.
A spacious dining area with high ceilings, large windows, and a green seating area.

17. DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza
Greenway Plaza-Upper Kirby, 6.6 km from South Main
United States
Nicole
$89
$105 total
includes taxes & fees
Sep 24 - Sep 25
DoubleTree by Hilton Hotel Houston - Greenway Plaza
A rooftop pool area with a covered seating area, a pool with a metal railing, and a cityscape view in the background.
A modern living room with a sectional sofa, a coffee table, and a TV area.
A modern conference room with multiple tables and chairs, a large flat-screen TV, and a bar area with shelves of bottles.
A Staybridge Suites hotel with a modern facade, large glass windows, and a prominent Holiday Inn Express sign.

18. Holiday Inn Express Houston - Galleria Area by IHG

Holiday Inn Express Houston - Galleria Area by IHG
The Galleria, 8.6 km from South Main
United States
Mireya
$127
$149 total
includes taxes & fees
Sep 20 - Sep 21
Holiday Inn Express Houston - Galleria Area by IHG
A hotel room with two beds, a sofa, a desk, and a TV.
A hotel hallway with a wooden door, a blue-framed mirror, a wooden shelf with a decorative item, and a bathroom visible through an open door.
A modern bathroom with a double sink vanity, a large mirror, a toilet, and a blue accent wall.
A reception area with a wooden reception desk, a large painting above it, and shelves with various items on either side.

19. Spark by Hilton Houston near the Galleria

Spark by Hilton Houston near the Galleria
9.6 km from South Main
United States
Sophia
$84
$98 total
includes taxes & fees
Sep 21 - Sep 22
Spark by Hilton Houston near the Galleria
A modern indoor pool area with a wooden table and chairs, a vase with flowers, and a view of the outside buildings.
A spacious kitchen with a central island, white cabinetry, and a large window overlooking a pool.
A spacious lobby with leather sofas, a coffee table, and a large window offering a view of the outdoors.
A hotel room with a kitchenette, a bed, a sofa, a table, and a chair.

20. Best Western Plus Downtown Inn & Suites

Best Western Plus Downtown Inn & Suites
10.2 km from South Main
United States
Michael
$116
$136 total
includes taxes & fees
Sep 24 - Sep 25
Best Western Plus Downtown Inn & Suites
View all properties

Compare popular hotels in South Main

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.
Comfort Suites Houston near Medical Center- NRG Stadium
8.8
Excellent
1,000 reviews
View
A modern lobby with a blue carpet, seating area, and large windows.
Wyndham Houston at Reliant Park & Medical Center
7.2
Good
1,404 reviews
View
A compact kitchen with dark cabinets, a microwave, a coffee maker, and a white countertop. There are two wicker chairs and a small table.
Candlewood Suites Houston Medical Center by IHG
7.4
Good
896 reviews
View
A spacious lobby with a central seating area, a bar, and a reception desk.
Wingate Houston at Reliant Park & Medical Center
6.6
1,001 reviews
View
A hotel room with a blue sofa, striped armchair, a small table, a TV on a cabinet, a microwave, and a door leading to a bedroom.
Quality Inn & Suites NRG Park - Medical Center
6.6
1,001 reviews
View
Our prices for hotels in South Main are cheapest in August
Price trends for hotels in South Main
Pricing is based on two traveler single night rates
View properties in September
Typical weather for Houston
September
High 32°C / low 23°C. Sunny most days.
View properties in September
32°
23°
28°
19°
22°
13°
18°
10°
17°
8°
19°
10°
23°
14°
26°
17°
30°
21°
33°
24°
34°
25°
34°
26°
Monthly weather averages (˚C)

Check out reviews of South Main hotels guests love

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

10/10 Excellent
"Staff was very kind and helpful"
Jose 3-night trip
Posted 1 hour ago
Hilton Houston Plaza/Medical Center
DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza

10/10 Excellent
"Great Place to stay I’ll be back"
Sheldon 2-night trip
Posted 5 hours ago
DoubleTree by Hilton Hotel Houston - Greenway Plaza
La Quinta Inn & Suites by Wyndham Houston Bush IAH South

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

8/10 Good
"Excellent service from all angles. Made me feel at home."
MIGUEL 1-night trip
Posted 6 hours ago
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
Wyndham Houston at Reliant Park & Medical Center

Wyndham Houston at Reliant Park & Medical Center

8/10 Good
"The best thing about this was the location. We attended the AC/DC concert and this hotel was within walking distance. I would only stay if attending an event at the Reliant Staduim. Not bad, but not the best."
Christie 2-night trip
Posted 1 day ago
Wyndham Houston at Reliant Park & Medical Center
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