Hotels in South Main
Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices
Check prices for these dates
Where to stay in South Main?

Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (996 reviews)
The price is $98
$115 total
includes taxes & fees
Jan 16 - Jan 17

Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,204 reviews)
The price is $116
$136 total
includes taxes & fees
Jan 16 - Jan 17

Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,000 reviews)
The price is $73
$86 total
includes taxes & fees
Jan 25 - Jan 26

Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (829 reviews)
The price is $78
$91 total
includes taxes & fees
Jan 17 - Jan 18

Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,017 reviews)
The price is $86
$100 total
includes taxes & fees
Jan 18 - Jan 19

Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG1.4 km from South Main
9.4 out of 10, Exceptional, (1,001 reviews)
The price is $125
$147 total
includes taxes & fees
Jan 21 - Jan 22

The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum DistrictTexas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,053 reviews)
The price is $153
$191 total
includes taxes & fees
Jan 18 - Jan 19

Hyatt Place Houston Medical Center
Hyatt Place Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2,252 reviews)
The price is $117
$138 total
includes taxes & fees
Feb 5 - Feb 6

SpringHill Suites Houston Medical Center/NRG Park
SpringHill Suites Houston Medical Center/NRG ParkAstrodome, 2.4 km from South Main
9.0 out of 10, Wonderful, (1,001 reviews)
The price is $101
$118 total
includes taxes & fees
Jan 23 - Jan 24

Hampton Inn & Suites Houston Medical Center NRG Park
Hampton Inn & Suites Houston Medical Center NRG ParkTexas Medical Center, 3 km from South Main
8.2 out of 10, Very Good, (1,009 reviews)
The price is $102
$120 total
includes taxes & fees
Jan 23 - Jan 24

Blossom Hotel Houston, Curio Collection by Hilton
Blossom Hotel Houston, Curio Collection by HiltonTexas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3,649 reviews)
The price is $139
$162 total
includes taxes & fees
Jan 22 - Jan 23

Hilton Garden Inn Houston Medical Center, TX
Hilton Garden Inn Houston Medical Center, TXTexas Medical Center, 4.7 km from South Main
9.4 out of 10, Exceptional, (1,000 reviews)
The price is $114
$133 total
includes taxes & fees
Jan 22 - Jan 23

Hyatt House Houston Medical Center
Hyatt House Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1,218 reviews)
The price is $110
$129 total
includes taxes & fees
Feb 6 - Feb 7

Crowne Plaza Houston Med Ctr-Galleria Area by IHG
Crowne Plaza Houston Med Ctr-Galleria Area by IHG6.5 km from South Main
7.6 out of 10, Good, (1,315 reviews)
The price is $67
$78 total
includes taxes & fees
Jan 19 - Jan 20

Home2 Suites by Hilton Houston Medical Center, TX
Home2 Suites by Hilton Houston Medical Center, TXTexas Medical Center, 4.7 km from South Main
9.4 out of 10, Exceptional, (587 reviews)
The price is $122
$143 total
includes taxes & fees
Jan 22 - Jan 23

DoubleTree by Hilton Hotel Houston - Greenway Plaza
DoubleTree by Hilton Hotel Houston - Greenway Plaza6.6 km from South Main
8.4 out of 10, Very Good, (1,427 reviews)
The price is $114
$133 total
includes taxes & fees
Jan 22 - Jan 23

Hyatt Regency Houston/Galleria
Hyatt Regency Houston/Galleria8.7 km from South Main
9.0 out of 10, Wonderful, (1,199 reviews)
The price is $152
$208 total
includes taxes & fees
Jan 29 - Jan 30

Sonesta ES Suites Houston Galleria
Sonesta ES Suites Houston GalleriaThe Galleria, 8.4 km from South Main
8.2 out of 10, Very Good, (1,144 reviews)
The price is $93
$108 total
includes taxes & fees
Jan 19 - Jan 20

Hyatt Place Houston/Galleria
Hyatt Place Houston/Galleria8.7 km from South Main
8.8 out of 10, Excellent, (1,334 reviews)
The price is $129
$152 total
includes taxes & fees
Jan 21 - Jan 22

The Royal Sonesta Houston Galleria
The Royal Sonesta Houston GalleriaThe Galleria, 8.8 km from South Main
8.4 out of 10, Very Good, (1,553 reviews)
The price is $159
$186 total
includes taxes & fees
Jan 23 - Jan 24
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check out reviews of South Main hotels guests love

Heritage Place Houston Brookhollow
10/10 Excellent
Find out more about South Main




































































