Hotels in Pine Island

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Where to stay in Pine Island?

Spark by Hilton Rochester South
Spark by Hilton Rochester South
3.0 star property
Rochester
9.4 out of 10, Exceptional, (438 reviews)
Within 10 minutes of Mayo Clinic, this welcoming Rochester hotel offers free breakfast, WiFi, and parking. Swim in the indoor pool, stay fit at the on-site gym, and experience friendly service that guests consistently praise.
The price is $73
$84 total
includes taxes & fees
May 3 - May 4
Spark by Hilton Rochester South
Holiday Inn Express Rochester South - Mayo Area by IHG
Holiday Inn Express Rochester South - Mayo Area by IHG
2.5 star property
Rochester
8.8 out of 10, Excellent, (1,004 reviews)
Relax at this Rochester hotel just minutes from Mayo Clinic. Wake up to a free hot breakfast, unwind in the indoor pool, or keep up your routine at the fitness center. Clean rooms with fridges and microwaves offer comfort after hospital visits.
The price is $82
$94 total
includes taxes & fees
Apr 19 - Apr 20
Holiday Inn Express Rochester South - Mayo Area by IHG
Baymont by Wyndham Rochester Mayo Clinic Area
Baymont by Wyndham Rochester Mayo Clinic Area
2.5 star property
Rochester
7.2 out of 10, Good, (763 reviews)
The price is $60
$69 total
includes taxes & fees
Apr 21 - Apr 22
Baymont by Wyndham Rochester Mayo Clinic Area
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (989 reviews)
Steps from Rochester Public Library and Shops University Square, this hotel offers peaceful rooms and a rooftop terrace. Enjoy American cuisine at Crave restaurant, grab snacks at the deli, or unwind at the bar after using the fitness center.
The price is $99
$114 total
includes taxes & fees
May 10 - May 11
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Broadway Plaza, Trademark Collection by Wyndham
Broadway Plaza, Trademark Collection by Wyndham
3.0 star property
Downtown Rochester
9.2 out of 10, Wonderful, (174 reviews)
The price is $161
$185 total
includes taxes & fees
Apr 24 - Apr 25
Broadway Plaza, Trademark Collection by Wyndham
Super 8 by Wyndham Rochester Mayo Clinic Area
Super 8 by Wyndham Rochester Mayo Clinic Area
2.0 star property
Rochester
7.8 out of 10, Good, (1,005 reviews)
Tranquil accommodations just 5 minutes from Mayo Clinic with complimentary on-the-go breakfast served each morning. Guests consistently praise the helpful staff and quiet atmosphere. Apache Mall and Olmsted County Fairgrounds are located nearby.
The price is $52
$60 total
includes taxes & fees
Apr 26 - Apr 27
Super 8 by Wyndham Rochester Mayo Clinic Area
Hilton Rochester Mayo Clinic Area
Hilton Rochester Mayo Clinic Area
3.5 star property
Downtown Rochester
9.6 out of 10, Exceptional, (588 reviews)
Steps from Mayo Clinic, this hotel offers a rejuvenating full-service spa plus 2 restaurants. After treatments, relax in the indoor pool or unwind at the bar. Rooms include microwaves and refrigerators for extended medical stays.
The price is $171
$197 total
includes taxes & fees
Apr 24 - Apr 25
Hilton Rochester Mayo Clinic Area
Quality Inn & Suites Mayo Clinic Area
Quality Inn & Suites Mayo Clinic Area
2.5 star property
Rochester
8.8 out of 10, Excellent, (869 reviews)
This hotel offers peaceful rooms just 5 minutes from Mayo Clinic, with complimentary full breakfast and parking. Nearby restaurants and shops enhance convenience, while attentive staff ensure a comfortable stay near Olmsted County Fairgrounds.
The price is $77
$89 total
includes taxes & fees
May 3 - May 4
Quality Inn & Suites Mayo Clinic Area
Hilton Garden Inn Rochester Downtown, MN
Hilton Garden Inn Rochester Downtown, MN
3.0 star property
Downtown Rochester
8.8 out of 10, Excellent, (889 reviews)
Immerse yourself in the heart of Rochester at this convenient hotel, just a 5-minute drive from Mayo Clinic. Enjoy the indoor pool, hot tub, and 24-hour fitness center after exploring nearby University Square shops.
The price is $114
$131 total
includes taxes & fees
Apr 24 - Apr 25
Hilton Garden Inn Rochester Downtown, MN
Red Carpet Inn Rochester
Red Carpet Inn Rochester
2.0 star property
Rochester
7.6 out of 10, Good, (538 reviews)
The price is $60
$69 total
includes taxes & fees
Apr 15 - Apr 16
Red Carpet Inn Rochester
Econo Lodge Mayo Clinic Area
Econo Lodge Mayo Clinic Area
2.0 star property
Rochester
9.0 out of 10, Wonderful, (961 reviews)
Wake up to a free full breakfast at this quiet hotel just 5 minutes from Mayo Clinic. Enjoy complimentary WiFi and parking, plus a 24-hour fitness center. The helpful staff and convenient location near Olmsted County Fairgrounds make this a peaceful choice.
The price is $69
$79 total
includes taxes & fees
May 7 - May 8
Econo Lodge Mayo Clinic Area
MainStay Suites Rochester South Mayo Clinic
MainStay Suites Rochester South Mayo Clinic
2.5 star property
Rochester
7.0 out of 10, Good, (101 reviews)
This extended-stay hotel offers free WiFi and parking only 10 minutes from Mayo Clinic. Spacious suites provide a home base while you're near major medical facilities, with Marcus Rochester Cinema and Olmsted County Fairgrounds close by.
The price is $54
$62 total
includes taxes & fees
May 8 - May 9
MainStay Suites Rochester South Mayo Clinic
Marriott Rochester Mayo Clinic
Marriott Rochester Mayo Clinic
3.5 star property
Downtown Rochester
8.4 out of 10, Very Good, (547 reviews)
Just a 5-minute drive from Mayo Clinic, this Rochester hotel offers an indoor pool, hot tub, and 24-hour fitness center. Grab a bite at the restaurant or enjoy a drink at the bar. Near Shops University Square and Plummer Building.
The price is $199
$229 total
includes taxes & fees
Apr 24 - Apr 25
Marriott Rochester Mayo Clinic
Candlewood Suites Rochester Mayo Clinic Area by IHG
Candlewood Suites Rochester Mayo Clinic Area by IHG
2.5 star property
Rochester
9.4 out of 10, Exceptional, (486 reviews)
This convenient Rochester hotel is just a 5-minute drive from Mayo Clinic with free WiFi and parking. Stay active in the 24-hour fitness center while enjoying business amenities. Olmsted County Fairgrounds and Apache Mall are located nearby.
The price is $101
$116 total
includes taxes & fees
Apr 26 - Apr 27
Candlewood Suites Rochester Mayo Clinic Area by IHG
Hyatt House Rochester/Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area
3.0 star property
Downtown Rochester
9.0 out of 10, Wonderful, (1,013 reviews)
This Rochester hotel offers a free area shuttle to nearby Mayo Clinic. Enjoy the indoor pool and hot tub after a long day, or grab a drink at the bar. The onsite fitness center, convenient in-room refrigerators, and helpful staff ensure a stress-free stay.
The price is $139
$160 total
includes taxes & fees
Apr 19 - Apr 20
Hyatt House Rochester/Mayo Clinic Area
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3.0 star property
Rochester
7.2 out of 10, Good, (1,041 reviews)
Situated just a 10-minute drive from Mayo Clinic, this hotel offers a complimentary buffet breakfast each morning. Guests appreciate the spotless rooms, free WiFi, and parking. The fitness center and proximity to local attractions add extra value.
The price is $71
$82 total
includes taxes & fees
Apr 19 - Apr 20
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Hampton Inn Rochester-South
Hampton Inn Rochester-South
2.5 star property
Rochester
9.0 out of 10, Wonderful, (1,000 reviews)
Unwind in this tranquil retreat just 5 minutes from Mayo Clinic. After enjoying the free breakfast, take a refreshing dip in the indoor pool or relax in the hot tub. The helpful staff, free WiFi, and convenient parking enhance your stay near Apache Mall.
The price is $93
$107 total
includes taxes & fees
May 10 - May 11
Hampton Inn Rochester-South
AmericInn by Wyndham Rochester Near Mayo Clinic
AmericInn by Wyndham Rochester Near Mayo Clinic
3.0 star property
Rochester
8.2 out of 10, Very Good, (1,259 reviews)
Steps from Mayo Clinic, this tranquil hotel offers an indoor pool and on-site dining at Crooked Pint Ale House. Rooms include microwaves and refrigerators while the quiet environment ensures restful recovery. Free breakfast and parking add convenience.
The price is $70
$80 total
includes taxes & fees
Apr 19 - Apr 20
AmericInn by Wyndham Rochester Near Mayo Clinic
The Towers At Kahler Grand Hotel
The Towers At Kahler Grand Hotel
4.0 star property
Downtown Rochester
9.4 out of 10, Exceptional, (99 reviews)
Business-friendly hotel near Mayo Clinic with free breakfast, WiFi, and valet parking. Dine at Lord Essex Tavern & Grill or relax in the indoor pool after appointments. Guests love the helpful staff and nearby Plummer Building and Shops University Square.
The price is $356
$410 total
includes taxes & fees
Apr 16 - Apr 17
The Towers At Kahler Grand Hotel
Kahler Grand Hotel
Kahler Grand Hotel
3.0 star property
Downtown Rochester
8.4 out of 10, Very Good, (2,000 reviews)
This historic Rochester hotel offers peaceful rooms near Mayo Clinic and Saint Marys Campus. Enjoy the indoor pool, 2 restaurants with American fare, and 24-hour fitness center. Guests praise the helpful staff and convenient location near Plummer Building.
The price is $127
$146 total
includes taxes & fees
Apr 19 - Apr 20
Kahler Grand Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Check out reviews of Pine Island hotels guests love

Frequently asked questions

What accommodations do travelers recommend in Pine Island?
Can I book refundable accommodations in Pine Island?
If you're looking for the flexibility to change your plans to Pine Island, most hotels provide refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in Pine Island be like during my vacation?
The warmest months in Pine Island are usually July and August with an average temp of 68°F. January and February are the chilliest months when the average temp is 22°F. The rainiest months are June and May.
Why should I book my Pine Island hotel with Hotels.com?
There are plenty of reasons to book your Pine Island travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.