Hotels in Santana

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Next weekend
In two weeks

Where to stay in Santana?

1. Hotel Vista Verde

Hotel Vista Verde
3.0 star property
Yauco
8.6 out of 10, Excellent, (337 reviews)
Escape to this peaceful Yauco hotel featuring 2 outdoor pools, a children's pool, and stunning views from the rooftop terrace. Enjoy meals at 2 restaurants, drinks at 2 bars, and explore nearby Río Loco and Lucchetti Lakes with complimentary breakfast and parking.
The price is $117
$133 total
includes taxes & fees
Nov 1 - Nov 2
Hotel Vista Verde

2. Hotel Colonial

Hotel Colonial
2.0 star property
Cárcel
9.4 out of 10, Exceptional, (1,183 reviews)
Discover this charming Mayagüez hotel near Plaza Colon and the cathedral. Free WiFi and parking enhance your stay, while the 24-hour front desk ensures round-the-clock assistance. Clean rooms provide a comfortable retreat after exploring nearby attractions.
The price is $99
$106 total
includes taxes & fees
Nov 1 - Nov 2
Hotel Colonial

3. Hotel Mayaguez Plaza, BW Signature Collection

Hotel Mayaguez Plaza, BW Signature Collection
3.0 star property
Cárcel
9.2 out of 10, Wonderful, (1,002 reviews)
This hotel offers free breakfast and WiFi in a spot that's near Plaza Colon and Catedral de Nuestra Senora de la Candelaria. Travelers appreciate the convenient access to main roads and central areas, plus the helpful staff makes exploring Mayagüez simple.
The price is $114
$124 total
includes taxes & fees
Nov 6 - Nov 7
Hotel Mayaguez Plaza, BW Signature Collection

4. Parador Guánica 1929

Parador Guánica 1929
3.0 star property
Guanica
9.0 out of 10, Wonderful, (831 reviews)
The price is $140
$152 total
includes taxes & fees
Nov 2 - Nov 3
Parador Guánica 1929

5. Costa Bahia Hotel & Convention Center

Costa Bahia Hotel & Convention Center
3.5 star property
Guayanilla
8.8 out of 10, Excellent, (2,230 reviews)
The price is $138
$165 total
includes taxes & fees
Nov 1 - Nov 2
Costa Bahia Hotel & Convention Center

6. Turtle Bay Inn

Turtle Bay Inn
3.5 star property
Lajas
9.4 out of 10, Exceptional, (519 reviews)
Sun-soaked relaxation awaits at this Lajas hotel with outdoor pool and garden. Lounge with drinks at the poolside bar or terrace. Near Isla Magueyes and El Malecón, with helpful staff ready to enhance your coastal getaway.
The price is $116
$124 total
includes taxes & fees
Nov 1 - Nov 2
Turtle Bay Inn

7. Parador Villa Parguera

Parador Villa Parguera
3.5 star property
Lajas
9.0 out of 10, Wonderful, (1,000 reviews)
Perched on La Parguera Bay, this seaside hotel offers refreshing dips in the outdoor pool and tropical cocktails at the poolside bar. Savor local flavors at Aquamarina Restaurant, then explore nearby Plaza San Pedro from this convenient base with free parking.
The price is $149
$159 total
includes taxes & fees
Nov 3 - Nov 4
Parador Villa Parguera

8. Hostal Universitario

Hostal Universitario
2.0 star property
San German
9.0 out of 10, Wonderful, (227 reviews)
This lively hostal in San Germán puts you near Casa de Lola Rodríguez de Tió and the town's cathedral. Rooms include refrigerators and microwaves while a garden and terrace offer relaxation spots. Enjoy kayaking and diving options with helpful staff to guide your stay.
The price is $70
$76 total
includes taxes & fees
Nov 1 - Nov 2
Hostal Universitario

9. Parguera Plaza Hotel - Adults Only

Parguera Plaza Hotel - Adults Only
4.0 star property
Lajas
9.6 out of 10, Exceptional, (1,005 reviews)
Immerse in beachside serenity at this adults-only haven in Lajas, featuring 4 restaurants and an outdoor pool with poolside bar. Near Plaza San Pedro and El Malecón, the hotel offers free breakfast, WiFi, and parking for a carefree stay.
The price is $165
$180 total
includes taxes & fees
Nov 30 - Dec 1
Parguera Plaza Hotel - Adults Only

10. Hacienda Tres Casitas

Hacienda Tres Casitas
3.0 star property
Cabo Rojo
9.8 out of 10, Exceptional, (196 reviews)
Tucked away in Cabo Rojo, this charming guesthouse offers a refreshing outdoor pool and serene garden setting. Explore nearby hiking trails, then unwind on your furnished balcony. Casa de Lola Rodríguez de Tió and local attractions are just a short drive away.
The price is $110
$182 total
includes taxes & fees
Nov 4 - Nov 5
Hacienda Tres Casitas

11. Tryp by Wyndham Mayaguez

Tryp by Wyndham Mayaguez
3.0 star property
Cárcel
9.2 out of 10, Wonderful, (1,001 reviews)
This Mayaguez hotel offers a refreshing seasonal outdoor pool and convenient fitness center. Located near Yaguez Theater and Christopher Columbus Statue, you'll appreciate the clean rooms and helpful staff that previous guests have praised.
The price is $137
$149 total
includes taxes & fees
Dec 1 - Dec 2
Tryp by Wyndham Mayaguez

12. La Jamaca

La Jamaca
3.0 star property
Lajas
9.2 out of 10, Wonderful, (1,000 reviews)
Escape to La Jamaca where aromatherapy sessions melt away stress by the outdoor pool. Minutes from Plaza San Pedro and El Malecón, this tranquil retreat offers a welcoming bar, snack deli, and attentive staff for a rejuvenating stay.
The price is $168
$193 total
includes taxes & fees
Nov 1 - Nov 2
La Jamaca

13. Hacienda Villa Sotomayor

Hacienda Villa Sotomayor
2.5 star property
Adjuntas
8.8 out of 10, Excellent, (308 reviews)
The price is $64
$79 total
includes taxes & fees
Nov 16 - Nov 17
Hacienda Villa Sotomayor

14. Holiday Inn Mayaguez and Tropical Casino by IHG

Holiday Inn Mayaguez and Tropical Casino by IHG
3.5 star property
Mayagüez
9.4 out of 10, Exceptional, (1,343 reviews)
Beachfront buzz meets tropical tranquility at this Mayagüez hotel with casino thrills and local cuisine. After trying your luck, cool off in the outdoor pool. Clean rooms put you close to Playa El Maní and offer easy access to dining and attractions.
The price is $156
$173 total
includes taxes & fees
Nov 5 - Nov 6
Holiday Inn Mayaguez and Tropical Casino by IHG

15. Palmeras Beach Apartments

Palmeras Beach Apartments
3.0 star property
Guanica
10.0 out of 10, Exceptional, (21 reviews)
Escape to waterfront comfort at these apartment-style villas in Guanica, where full kitchens and rainfall showers create a home-like retreat. Enjoy complimentary WiFi and parking while exploring nearby Santa Beach and La Jungla, or try local kayaking and scuba diving adventures.
The price is $55
$156 total
includes taxes & fees
Nov 3 - Nov 4
Palmeras Beach Apartments

16. Copamarina Beach Resort & Spa

Copamarina Beach Resort & Spa
4.0 star property
Guanica
9.2 out of 10, Wonderful, (1,002 reviews)
Find serenity at this Guanica resort offering a private beach, 2 outdoor pools, and water sports like sailing and kayaking. The spa pampers with massages and facials, while lush gardens create a tranquil backdrop for spectacular sunsets by the sea.
The price is $206
$270 total
includes taxes & fees
Nov 1 - Nov 2
Copamarina Beach Resort & Spa

17. Nautilus By La Jamaca Hotels-Downtown La Parguera

Nautilus By La Jamaca Hotels-Downtown La Parguera
2.0 star property
Lajas
9.4 out of 10, Exceptional, (301 reviews)
Experience the charm of La Parguera at this waterfront hotel with its own marina. Free WiFi keeps you connected while the attentive staff ensures a memorable stay. Just minutes from El Malecón and Plaza San Pedro, this Lajas gem combines seaside atmosphere with convenient comforts.
The price is $147
$168 total
includes taxes & fees
Nov 1 - Nov 2
Nautilus By La Jamaca Hotels-Downtown La Parguera

18. Douglas Highway Hotel

Douglas Highway Hotel
2.0 star property
Cabo Rojo
8.6 out of 10, Excellent, (444 reviews)
Discover serene comfort at this Cabo Rojo hotel featuring an outdoor pool and welcoming bar. Relax in rooms with balconies or patios, explore nearby Buye Beach, and enjoy helpful staff service with the convenience of free parking.
The price is $132
$144 total
includes taxes & fees
Nov 1 - Nov 2
Douglas Highway Hotel

19. West Coast Inn's

West Coast Inn's
3.0 star property
Cabo Rojo
7.8 out of 10, Good, (1,000 reviews)
The price is $80
$158 total
includes taxes & fees
Nov 2 - Nov 3
West Coast Inn's

20. Casa Patriota

Casa Patriota
2.0 star property
Lares
9.2 out of 10, Wonderful, (9 reviews)
The price is $53
$68 total
includes taxes & fees
Nov 1 - Nov 2
Casa Patriota
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Santana

The region around Santana is home to attractions such as Bosque Estatal de Maricao and Casa Morales.

A mangrove forest with water channels and distant hills.

Check out reviews of Santana hotels guests love

Frequently asked questions

What hotels do travelers like in Santana?
Guests like Hotel Vista Verde.
Can I book a refundable hotel in Santana?
If you need the flexibility to change your plans to Santana, most hotels offer refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in Santana be like during my visit?
Santana is a great place to visit any time of year with an average temperature of 76°F during the coldest months.
Why should I book my Santana accommodation with Hotels.com?
There are plenty of reasons to book your Santana travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.