Hotels in Byron

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Where to stay in Byron?

A Comfort Inn hotel with a stone facade, a covered entrance, and a parking area.

A spacious lobby with a central seating area, a reception desk, and a fireplace.

A modern dining area with wooden tables and chairs, a kitchen with granite countertops, and a view of the outdoors through large windows.

A spacious living room with a stone fireplace, blue sofas, and a flat-screen TV.

1. Comfort Inn & Suites West - Medical Center

Rochester

$89

$102 total

includes taxes & fees

Oct 10 - Oct 11

A spacious lobby with a reception desk, sofas, and a coffee table.

A lobby with a brown sofa, yellow armchairs, a coffee table, and a clock on the wall.

An indoor swimming pool with clear blue water, surrounded by tiled flooring and equipped with a pool ladder.

A Sleep Inn hotel with a covered entrance, stone pillars, and a clear blue sky.

2. Sleep Inn & Suites West-Near Medical Center

Rochester

$90

$104 total

includes taxes & fees

Oct 18 - Oct 19

A modern dining area with high tables, chairs, and pendant lighting.

A hotel room with two beds, a desk with a computer, a chair, and a window with a view.

A multi-story hotel with a modern design, featuring a prominent entrance with a covered area and a parking lot in front.

A reception desk with a large digital screen displaying a cityscape and the word "happy."

3. Hampton Inn & Suites Rochester-North

Rochester

$103

$118 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a large bed, a desk, a chair, a TV, and a window with curtains.

A compact hotel room with a kitchenette, a dining area, a sofa, and a bed.

A Microtel Inn & Suites building with a signboard, a parking lot, and a clear sky.

A hotel room with a large window, a clock, a framed picture of pottery, a desk with a computer, and a seating area with patterned chairs.

4. Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

Rochester

$70

$80 total

includes taxes & fees

Sep 28 - Sep 29

A modern hotel lobby with a reception desk, seating area, and a kitchenette.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

A hotel with a covered entrance, multiple floors, and a parking lot.

A hotel room with a large bed, a desk, a chair, and a kitchenette.

5. Spark by Hilton Rochester South

Rochester

$81

$93 total

includes taxes & fees

Oct 2 - Oct 3

An indoor swimming pool with a dolphin sculpture, wooden ceiling, and clear windows.

A hotel reception area with a coffee station, seating area, and a fireplace.

A hotel room with a large bed, two bedside tables with lamps, a telephone, and a window with sheer curtains.

A hotel room with a flat-screen TV, a sofa with a red pillow, a small table, and a lamp.

6. TownePlace Suites by Marriott Rochester

Rochester

$98

$113 total

includes taxes & fees

Oct 2 - Oct 3

A modern kitchen with dark wooden cabinets, a stainless steel refrigerator, a microwave, and a coffee maker. There is a dining area with two red chairs and a table.

An outdoor patio area with stone walls, outdoor seating, and landscaped gardens.

A compact hotel room with a kitchenette, a dining area, a seating area with a sofa and armchairs, and a large window with curtains.

A compact hotel room with a kitchenette, a bed, a TV, and a seating area.

7. Staybridge Suites Rochester - Commerce Dr NW by IHG

Rochester

$135

$155 total

includes taxes & fees

Oct 3 - Oct 4

A spacious living area with a wooden dining table, bar stools, and a patterned armchair. A staircase leads to an upper level with a balcony.

A spacious lobby with a high ceiling, a central seating area with patterned sofas and ottomans, a reception desk, and a staircase leading to an upper level.

A restaurant with a staircase, dining tables, chairs, a coffee machine, and a refrigerator.

8. Quality Inn near Medical Center

Rochester

$63

$72 total

includes taxes & fees

Oct 19 - Oct 20

A compact kitchen with white cabinets, a microwave, a refrigerator, a sink, and a chair.

A hotel lobby with two leather armchairs, a small round table, a 'WELCOME' sign, and a 'TRASH CAN' sign on the wall.

A hotel reception area with a black reception desk, a 'WELCOME' sign, a bench, and two armchairs.

9. Extended Stay America Suites Rochester North

Rochester

$64

$74 total

includes taxes & fees

Oct 9 - Oct 10

A hotel reception desk with a wooden counter, a computer, and a vase with flowers.

An indoor swimming pool with wooden beams and white chairs around it.

A living room with stone walls, a fireplace, leather furniture, and a ceiling fan.

A hotel room with a large bed, a view through a sliding glass door to an outdoor area, a nightstand with a lamp, and a wooden headboard.

10. Baymont by Wyndham Kasson Rochester Area

Kasson

$66

$71 total

includes taxes & fees

Oct 4 - Oct 5

A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.

An indoor swimming pool with a slide, seating area, and a large frog statue.

A modern kitchen with wooden cabinets, a microwave, an oven, and a dishwasher.

A hotel room with two beds, a desk, a chair, and a mirror.

11. AmericInn by Wyndham Rochester Near Mayo Clinic

Rochester

$78

$90 total

includes taxes & fees

Sep 27 - Sep 28

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A modern living room with a stone fireplace, a blue armchair, a round coffee table, and a large window offering a view of the outdoors.

A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

12. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park

$121

$139 total

includes taxes & fees

Oct 3 - Oct 4

A Holiday Inn Express building with a covered entrance, outdoor seating area, and a well-lit facade.

A coffee station with two espresso machines and a variety of coffee pods and cups.

A hotel dining area with multiple tables and chairs, a coffee station, and a seating area with sofas.

13. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Kutzky Park

$110

$127 total

includes taxes & fees

Oct 2 - Oct 3

An indoor swimming pool with slides, seating areas, and a covered section with umbrellas.

A hotel room with a kitchen area, a bed, a TV, and a seating area.

A modern kitchen with black cabinets, white countertops, and a tiled backsplash. There are pendant lights, a refrigerator, and a coffee machine.

A modern kitchen with a microwave, sink, and granite countertop.

14. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Rochester

$99

$114 total

includes taxes & fees

Oct 1 - Oct 2

An indoor swimming pool with clear water, wooden flooring, and a ceiling with wooden beams and lights.

A café with multiple tables and chairs, a kitchen area with appliances, and a clock on the wall.

A hotel room with two beds, a desk, a chair, a television, and a window with curtains.

A room with a TV mounted on the wall, a wooden table, and two patterned armchairs.

15. Med City Inn & Suites - Mayo Clinic Area

Kutzky Park

$71

$82 total

includes taxes & fees

Sep 27 - Sep 28

A hotel room with a large bed, bedside tables, a wall-mounted light, and a window with curtains.

A hotel lobby with a view of a swimming pool, a bench, and a potted plant.

A coffee station with three thermos dispensers labeled 'Regular,' 'Decaf,' and 'Hot Water,' and a poster advertising 'RISE & SHINE' complimentary coffee.

A reception area with a counter, seating, a plant, and informational signs.

16. Motel 6 Rochester, MN

Rochester

$55

$63 total

includes taxes & fees

Oct 2 - Oct 3

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

A modern hotel room with a bed, desk, and kitchenette.

A modern lounge area with a sofa, chairs, and tables.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

17. Home2 Suites by Hilton Rochester Mayo Clinic Area

Rochester

$122

$141 total

includes taxes & fees

Oct 3 - Oct 4

A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

A buffet counter with a variety of food items, a coffee station, and a beverage dispenser.

An indoor swimming pool with a slide, seating areas, and a lifeguard station.

A modern lobby with a teal sofa, yellow chairs, a small round table, and a fireplace with a TV.

18. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Rochester

$76

$87 total

includes taxes & fees

Oct 4 - Oct 5

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A modern reception area with a wooden reception desk, glass pendant lights, and a long hallway with seating.

A modern living room with a dark wall, a decorative light fixture, and a patterned wall art piece.

A restaurant interior with wooden tables, chairs, and a stone wall.

19. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Historic Southwest

$108

$124 total

includes taxes & fees

Oct 2 - Oct 3

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

20. Hampton Inn Rochester-South

Rochester

$106

$122 total

includes taxes & fees

Oct 4 - Oct 5

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Go beyond your typical stay in Byron

Pet friendly

Pool

Hot tub

Family friendly

Top landmarks in Byron

Oxbow Park

8.8/10 (5 reviews)

Oxbow Park is 3.4 mi (5.5 km) from central Byron, why not stop by during your stay. Our travelers also like this walkable area for its restaurants. If you like Oxbow Park, you'll love Douglas State Trail Head Rochester, just a short drive away.

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Community Center Park

Community Center Park is worth a visit when in central Byron.

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Putting Green

You might want to play some rounds at Putting Green, located 1.2 mi (1.9 km) from central Byron. If Putting Green doesn't quite scratch your golfing itch, Somerby Golf Club, and Links of Byron Mini Golf are also nearby.

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Somerby Park

Somerby Park is worth a visit, located 0.8 mi (1.3 km) from central Byron.

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East Brookfield Park

East Brookfield Park is worth a visit, located 0.7 mi (1.1 km) from central Byron.

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High Point Shopping Center

If you like shopping, take time out to go to High Point Shopping Center when in Byron. Splash some more cash at Byron Town Square.

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Zollman Zoo

It's feeding time at the zoo! If you want to be reminded of some of the great animals our world is home to, you might want to pay a trip to Zollman Zoo, located 3.5 mi (5.7 km) from central Byron. If you'd also like to explore some of the parks in Byron, Oxbow Park is a short walk away.

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Salem Town Hall

Salem Town Hall is worth a visit, located 3.7 mi (6 km) from central Byron.

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Check out reviews of Byron hotels guests love

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

8/10 Good

"The hotel is clean, comfortable, and offers easy parking. Mayo Clinic is within walking distance (half mile). The staff is helpful and friendly. Bonus: the pool and hot tub area is very relaxing!"

Kahler Grand Hotel

10/10 Excellent

"Really pleasant stay, has an amazing old charm that feels unique"

Hyatt House Rochester/Mayo Clinic Area

8/10 Good

"Clean rooms. Standard hot breakfast stuff. Liked that they had wheelchairs available. Disliked loud train whistles at 9pm and 5:50am! Also a fair amount of traffic noise could be heard (on 4th floor facing Civic Center Blvd.). Indoor parking lot is small and full at peak times. Had to park 1.5 blocks away."

AmericInn by Wyndham Rochester Near Mayo Clinic

8/10 Good

"Clean room and nice breakfast. Pub on site was a bonus. They had great food."

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

10/10 Excellent

"Very nice place! I would definitely stay there again."

Holiday Inn Express Rochester South - Mayo Area by IHG

10/10 Excellent

"Room was very clean, staff was amazing. Hot tub not working."

Comfort Inn & Suites Rochester South Mayo Clinic

10/10 Excellent

"We stayed one night and it was by far one of the nicer hotels we stayed in on our trip"

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

10/10 Excellent

"We had a great night of sleep after a long day at Mayo. The bed was comfortable. Hotel was clean and staff was helpful and very friendly. The breakfast was good with many options."

Kahler Inn and Suites - Mayo Clinic Area

8/10 Good

"Staff at check in,close to mayo"

Frequently asked questions

What hotels do travelers recommend in Byron?

Guests like AmericInn by Wyndham Rochester Near Mayo Clinic, Kahler Grand Hotel and Kahler Inn and Suites - Mayo Clinic Area.

Can I book refundable accommodations in Byron?

If you're looking for the flexibility to change your plans to Byron, most properties provide refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in Byron be like during my vacation?

July and August are typically the warmest months in Byron when the average temp is 67°F. January and February are the coldest months when the average temperature is 21°F. June and May are the months with the most rain.

Why should I book my Byron hotel with Hotels.com?

There are lots of reasons to book your Byron trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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