Hotels in Byron

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Holiday Inn Express Rochester South - Mayo Area by IHG
Holiday Inn Express Rochester South - Mayo Area by IHG
2.5 star property
Rochester
8.8 out of 10, Excellent, (1,000 reviews)
  • cleanliness
    Modern rooms near Mayo Clinic with indoor pool and free hot breakfast daily.
The price is $74
$85 total
includes taxes & fees
Jan 30 - Jan 31
Holiday Inn Express Rochester South - Mayo Area by IHG
Hampton Inn Rochester-South
Hampton Inn Rochester-South
2.5 star property
Rochester
9.0 out of 10, Wonderful, (1,003 reviews)
  • cleanliness
    Peaceful hotel near Mayo Clinic with indoor pool and daily complimentary breakfast.
The price is $82
$95 total
includes taxes & fees
Feb 13 - Feb 14
Hampton Inn Rochester-South
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (917 reviews)
  • cleanliness
    Relax in quiet comfort with Mayo Clinic just a 15-minute walk away from this hotel.
The price is $93
$107 total
includes taxes & fees
Jan 30 - Jan 31
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Comfort Inn & Suites West - Medical Center
Comfort Inn & Suites West - Medical Center
3.0 star property
Rochester
9.0 out of 10, Wonderful, (539 reviews)
  • cleanliness
    Stay minutes from Mayo Clinic with indoor pool and fitness center access.
The price is $83
$96 total
includes taxes & fees
Jan 30 - Jan 31
Comfort Inn & Suites West - Medical Center
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3.0 star property
Rochester
7.2 out of 10, Good, (1,032 reviews)
  • cleanliness
    Convenient location near Mayo Clinic with free daily breakfast and on-site fitness.
The price is $77
$88 total
includes taxes & fees
Jan 23 - Jan 24
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Comfort Inn & Suites Rochester South Mayo Clinic
Comfort Inn & Suites Rochester South Mayo Clinic
2.0 star property
Rochester
8.8 out of 10, Excellent, (1,000 reviews)
  • cleanliness
    Stay minutes from Rochester airport with a rejuvenating pool and hot tub.
The price is $76
$87 total
includes taxes & fees
Feb 19 - Feb 20
Comfort Inn & Suites Rochester South Mayo Clinic
America's Stay Inn Stewartville
America's Stay Inn Stewartville
2.5 star property
Stewartville
8.0 out of 10, Very Good, (422 reviews)
  • cleanliness
    Explore Mayo Clinic just 15 minutes away from this convenient Stewartville hotel.
The price is $65
$70 total
includes taxes & fees
Jan 23 - Jan 24
America's Stay Inn Stewartville
Kahler Grand Hotel
Kahler Grand Hotel
3.0 star property
Downtown Rochester
8.4 out of 10, Very Good, (1,848 reviews)
  • cleanliness
    Quiet historic escape with indoor pool, minutes from Mayo Clinic facilities.
The price is $127
$146 total
includes taxes & fees
Jan 24 - Jan 25
Kahler Grand Hotel
Hilton Garden Inn Rochester Downtown, MN
Hilton Garden Inn Rochester Downtown, MN
3.0 star property
Downtown Rochester
8.8 out of 10, Excellent, (867 reviews)
  • cleanliness
    A welcoming downtown haven near Mayo Clinic with indoor pool and hot tub.
The price is $107
$123 total
includes taxes & fees
Jan 30 - Jan 31
Hilton Garden Inn Rochester Downtown, MN
AmericInn by Wyndham Rochester Near Mayo Clinic
AmericInn by Wyndham Rochester Near Mayo Clinic
3.0 star property
Rochester
8.0 out of 10, Very Good, (1,182 reviews)
  • cleanliness
    Peaceful retreat near Mayo Clinic with serene atmosphere and indoor pool.
The price is $76
$88 total
includes taxes & fees
Jan 25 - Jan 26
AmericInn by Wyndham Rochester Near Mayo Clinic
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
3.0 star property
Kutzky Park
9.2 out of 10, Wonderful, (777 reviews)
The price is $104
$120 total
includes taxes & fees
Jan 30 - Jan 31
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
Hampton Inn & Suites Rochester-North
Hampton Inn & Suites Rochester-North
2.5 star property
Rochester
9.2 out of 10, Wonderful, (1,000 reviews)
  • cleanliness
    Modern Rochester hotel with Mayo Clinic access and revitalizing pool amenities.
The price is $89
$103 total
includes taxes & fees
Feb 1 - Feb 2
Hampton Inn & Suites Rochester-North
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys
2.5 star property
Kutzky Park
9.6 out of 10, Exceptional, (685 reviews)
  • cleanliness
    Stay moments from Mayo Clinic with shuttle service at this well-appointed hotel.
The price is $98
$113 total
includes taxes & fees
Feb 6 - Feb 7
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys
Staybridge Suites Rochester - Commerce Dr NW by IHG
Staybridge Suites Rochester - Commerce Dr NW by IHG
3.0 star property
Rochester
8.8 out of 10, Excellent, (513 reviews)
  • cleanliness
    Spacious suites with indoor pool just minutes from Mayo Clinic medical campuses.
The price is $114
$131 total
includes taxes & fees
Jan 23 - Jan 24
Staybridge Suites Rochester - Commerce Dr NW by IHG
Econo Lodge Mayo Clinic Area
Econo Lodge Mayo Clinic Area
2.0 star property
Rochester
9.0 out of 10, Wonderful, (921 reviews)
  • cleanliness
    Restful retreat near Mayo Clinic with 24-hour fitness center and complimentary perks.
The price is $63
$73 total
includes taxes & fees
Feb 13 - Feb 14
Econo Lodge Mayo Clinic Area
Spark by Hilton Rochester South
Spark by Hilton Rochester South
3.0 star property
Rochester
9.4 out of 10, Exceptional, (360 reviews)
  • cleanliness
    Cozy lodging near Mayo Clinic with complimentary breakfast and indoor pool access.
The price is $71
$81 total
includes taxes & fees
Feb 1 - Feb 2
Spark by Hilton Rochester South
Brentwood Inn & Suites
Brentwood Inn & Suites
2.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (1,005 reviews)
  • cleanliness
    Comfortable beds near Mayo Clinic with free breakfast and helpful staff.
The price is $106
$122 total
includes taxes & fees
Jan 23 - Jan 24
Brentwood Inn & Suites
Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic
Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic
2.0 star property
Rochester
8.0 out of 10, Very Good, (1,000 reviews)
  • cleanliness
    Serene stay near Mayo Clinic with complimentary morning fare and fitness options.
The price is $65
$74 total
includes taxes & fees
Jan 30 - Jan 31
Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic
Aspen Select
Aspen Select
3.5 star property
Kutzky Park
8.4 out of 10, Very Good, (1,002 reviews)
  • cleanliness
    Convenient base for Mayo Clinic visits with fitness center and complimentary perks.
The price is $106
$128 total
includes taxes & fees
Jan 23 - Jan 24
Aspen Select
EVEN Hotel Rochester - Mayo Clinic Area by IHG
EVEN Hotel Rochester - Mayo Clinic Area by IHG
4.0 star property
Kutzky Park
9.4 out of 10, Exceptional, (981 reviews)
  • cleanliness
    Located near Mayo Clinic with wellness-focused amenities and an indoor pool.
The price is $114
$133 total
includes taxes & fees
Jan 30 - Jan 31
EVEN Hotel Rochester - Mayo Clinic Area by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

What hotels do travelers recommend in Byron?
Can I book refundable accommodations in Byron?
If you're looking for the flexibility to change your plans to Byron, most properties provide refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in Byron be like during my vacation?
July and August are typically the warmest months in Byron when the average temp is 67°F. January and February are the coldest months when the average temperature is 21°F. June and May are the months with the most rain.
Why should I book my Byron hotel with Hotels.com?
There are lots of reasons to book your Byron trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.